Article (Scientific journals)
Cis-drivers and trans-drivers of bovine leukemia virus oncogenesis
Safari, Roghaiyeh; Hamaïdia, Malik; De Brogniez, Alix et al.
2017In Current Opinion in Virology, 26, p. 15-19
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Keywords :
BLV; oncogenesis
Abstract :
[en] The bovine leukemia virus (BLV) is a retrovirus inducing an asymptomatic and persistent infection in ruminants and leading in a minority of cases to the accumulation of B-lymphocytes (lymphocytosis, leukemia or lymphoma). Although the mechanisms of oncogenesis are still largely unknown, there is clear experimental evidence showing that BLV infection drastically modifies the pattern of gene expression of the host cell. This alteration of the transcriptome in infected Blymphocytes results first, from a direct activity of viral proteins (i.e. transactivation of gene promoters, protein–protein interactions), second, from insertional mutagenesis by proviral integration (cis-activation) and third, from gene silencing by microRNAs. Expression of viral proteins stimulates a vigorous immune response that indirectly modifies gene transcription in other cell types (e.g. cytotoxic T-cells, auxiliary T-cells, macrophages). In principle, insertional mutagenesis and microRNA-associated RNA interference can modify the cell fate without inducing an antiviral immunity. Despite a tight control by the immune response, the permanent attempts of the virus to replicate ultimately induce mutations in the infected cell. Accumulation of these genomic lesions and Darwinian selection of tumor clones are predicted to lead to cancer.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Safari, Roghaiyeh ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Microbial, food and biobased technologies
Hamaïdia, Malik  ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Microbial, food and biobased technologies
De Brogniez, Alix ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.
Gillet, Nicolas ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.
Willems, Luc  ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Microbial, food and biobased technologies
Language :
English
Title :
Cis-drivers and trans-drivers of bovine leukemia virus oncogenesis
Publication date :
2017
Journal title :
Current Opinion in Virology
ISSN :
1879-6257
eISSN :
1879-6265
Publisher :
Elsevier B.V.
Special issue title :
Viruses and cancer
Volume :
26
Pages :
15-19
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
BELVIR
Plan Cancer of the Service Public Fédéral
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Télévie [BE]
Belgian Foundation Against Cancer [BE]
CAC - Centre anticancéreux près l'Université de Liège asbl [BE]
Fonds Léon Fredericq [BE]
ULiège. GxABT - Liège Université. Gembloux Agro-Bio Tech [BE]
ULg FSR - Université de Liège. Fonds spéciaux pour la recherche [BE]
Funding text :
the Interuniversity Attraction Poles
Available on ORBi :
since 31 January 2018

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