[en] BACKGROUND: Treatment of canine idiopathic eosinophilic bronchopneumopathy mainly consists of long-term oral corticosteroid therapy. To avoid side effects, inhaled steroid therapy has been increasingly used but long-term clinical response and potential side effects are sparsely described. OBJECTIVES: Description of clinical response and side effects with long-term fluticasone in dogs with eosinophilic bronchopneumopathy. METHODS: Case series of dogs with eosinophilic bronchopneumopathy and treated with fluticasone monotherapy for at least 6 months. Clinical response and side effects assessed by physical examination, standardised questionnaire and ACTH (corticotropin) stimulation test. RESULTS: Eight dogs were treated for between 6 months and 5 years. Cough initially improved in all dogs; two dogs remained free of clinical signs, three were well controlled, but three showed severe relapse. Pituitary-adrenal axis inhibition occurred in two dogs treated with fluticasone monotherapy for more than 2 years; only one dog had clinical signs of iatrogenic hyperadrenocorticism. CLINICAL SIGNIFICANCE: Fluticasone monotherapy allows initial improvement or remission in the majority of dogs but long-term treatment fails to resolve the cough in some individuals. In addition, such therapy may induce pituitary-adrenal axis inhibition. Prospective larger and randomised studies including both fluticasone and orally-treated dogs are needed to define the optimal treatment.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Canonne, A. M.
Bolen, Géraldine ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Imagerie médicale
Peeters, Dominique ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des animaux de compagnie
Billen, Frédéric ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux
Clercx, Cécile ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux
Language :
English
Title :
Long-term follow-up in dogs with idiopathic eosinophilic bronchopneumopathy treated with inhaled steroid therapy.
Publication date :
2016
Journal title :
Journal of Small Animal Practice
ISSN :
0022-4510
eISSN :
1748-5827
Publisher :
Wiley, Oxford, United Kingdom
Volume :
57
Issue :
10
Pages :
537-542
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2016 British Small Animal Veterinary Association.
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