Article (Scientific journals)
Primary bone diffuse large B-cell lymphoma: a retrospective evaluation on 76 cases from French institutional and LYSA studies
Pilorge, Sylvain; Harel, Stephanie; Ribrag, Vincent et al.
2016In Leukemia and Lymphoma, 57, p. 2820-2826
Peer Reviewed verified by ORBi
 

Files


Full Text
Leukemia & lymphoma-Primary bone diffuse large B-cell....pdf
Publisher postprint (1.19 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
aa-IPI; DLBCL; radiotherapy; Rituximab; primary bone lymphoma
Abstract :
[en] Primary bone diffuse large B-cell lymphoma (PB-DLBCL) is a rare DLBCL location variant. We treated 76 PB-DLBCL patients by immuno-chemotherapy, resulting in an 84% sustained complete remission rate and a 78.9% survival over a 4.7-year median follow-up period. Ann Arbor stage IV and high age-adjusted international prognostic index were predictive of adverse outcome in univariate analysis. In multivariate analysis using a Cox model, only aa-IPI predicted long-term survival. While based on a limited number of cases, we suggested that radiotherapy may be useful as a consolidation modality in PB-DLBCL. We also suggested that positron emission tomography/CT scan should be interpreted with caution due to a persistent [18F]fluorodeoxyglucose [18FDG] uptake of bone lesions even after remission in some in PB-DLBCL patients. Our study based on a homogeneous cohort of PB-DLBCL patients confirmed the favorable outcome of this DLBCL variant and support the implementation of prospective clinical trials in this disease.
Disciplines :
Hematology
Author, co-author :
Pilorge, Sylvain
Harel, Stephanie
Ribrag, Vincent
Larousserie, Frédérique
Willems, Lise
Franchi, Patricia
Legoff, Marielle
Biau, David
Anract, Philippe
Roux, Christian
Blanc-Autran, Estelle
Delarue, Richard
Gisselbrecht, Christian
Ketterer, Nicolas
Recher, Christian
Bonnet, Christophe ;  Université de Liège > GIGA-R : Hématologie
Peyrade, Frederic
Haioun, Corinne
Tilly, Hervé
Salles, Gilles
Brice, Pauline
Bouscary, Didier
Deau, Bénédicte
Tamburini, Jerome
More authors (14 more) Less
Language :
English
Title :
Primary bone diffuse large B-cell lymphoma: a retrospective evaluation on 76 cases from French institutional and LYSA studies
Publication date :
2016
Journal title :
Leukemia and Lymphoma
ISSN :
1042-8194
eISSN :
1029-2403
Publisher :
Taylor & Francis, London, United Kingdom
Volume :
57
Pages :
2820-2826
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 January 2018

Statistics


Number of views
367 (1 by ULiège)
Number of downloads
505 (0 by ULiège)

Scopus citations®
 
14
Scopus citations®
without self-citations
13
OpenCitations
 
12

Bibliography


Similar publications



Contact ORBi