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Computational modelling of human mesenchymal stem cell proliferation and extra cellular matrix production in 3D porous scaffolds in a perfusion bioreactor
Mehrian, Mohammad; Papantoniou, Ioannis; Lambrechts, Toon et al.
2018In Proceedings of the 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE)
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Keywords :
Computational modelling; mesenchymal stem cell proliferation; perfusion bioreactor; extra cellular matrix production
Abstract :
[en] 3D porous scaffolds are frequently used in tissue engineering (TE) applications in combination with bioreactor systems because of their ability to induce reproducible culture conditions that can control specific cell behavior such as proliferation and extracellular matrix (ECM) production. A computational model describing neotissue growth inside 3D scaffolds in a perfusion bioreactor was developed, with neotissue being considered the combination of cells and their extra cellular matrix. In the model, the speed of neotissue growth depends on the flow-induced shear stress, curvature and the local concentrations of oxygen, glucose and lactate. The goal of this study is to make a distinction between the cell and the ECM fraction within the neotissue in the model to allow for a more detailed validation and optimization of the process.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Mehrian, Mohammad ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique
Papantoniou, Ioannis
Lambrechts, Toon
Geris, Liesbet  ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique
Language :
English
Title :
Computational modelling of human mesenchymal stem cell proliferation and extra cellular matrix production in 3D porous scaffolds in a perfusion bioreactor
Publication date :
26 March 2018
Event name :
15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering
Event organizer :
Instituto Superior Técnico
Event place :
LISBON, Portugal
Event date :
From 26-03-2018 to 29-03-2018
Audience :
International
Main work title :
Proceedings of the 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE)
Peer reviewed :
Peer reviewed
Available on ORBi :
since 23 January 2018

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