Epstein-Barr virus and human herpesvirus 6 detection in a non-Hodgkin's diffuse large B-cell lymphoma cohort by using RNA sequencing.

Strong, Michael J.; O'Grady, Tina; Lin, Zhen; Xu, Guorong; Baddoo, Melody; Parsons, Chris; Zhang, Kun; Taylor, Christopher M.; Flemington, Erik K.

doi:10.1128/JVI.02380-13

Article (Scientific journals)

Epstein-Barr virus and human herpesvirus 6 detection in a non-Hodgkin's diffuse large B-cell lymphoma cohort by using RNA sequencing.

Strong, Michael J.; O'Grady, Tina; Lin, Zhen et al.

2013 • In Journal of Virology, 87 (23), p. 13059-62

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/218878

DOI
10.1128/JVI.02380-13

PubMed
24049168

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Keywords :

Cohort Studies; Epstein-Barr Virus Infections/diagnosis/virology; Gene Expression Regulation, Viral; Herpesvirus 4, Human/genetics/isolation & purification; Herpesvirus 6, Human/genetics/isolation & purification; Humans; Lymphoma, Large B-Cell, Diffuse/diagnosis/virology; Roseolovirus Infections/diagnosis/virology; Sequence Analysis, RNA; Viral Proteins/genetics

Abstract :

[en] Comprehensive virome analysis of RNA sequence (RNA-seq) data sets from 118 non-Hodgkin's B-cell lymphomas revealed a small subset that is positive for Epstein-Barr virus (EBV) or human herpesvirus 6B (HHV-6B), with one coinfection. EBV transcriptome analysis revealed expression of the latency genes RPMS1, LMP1, and LMP2, with one sample additionally showing a high level of early lytic expression and another sample showing a high level of EBNA2 expression. HHV-6B transcriptome analysis revealed that the majority of genes were transcribed.

Disciplines :

Human health sciences: Multidisciplinary, general & others

Author, co-author :

Strong, Michael J.

O'Grady, Tina ; Université de Liège - ULiège > Département des sciences de la vie > Génétique et biologie moléculaires animales

Lin, Zhen

Xu, Guorong

Baddoo, Melody

Parsons, Chris

Zhang, Kun

Taylor, Christopher M.

Flemington, Erik K.

Language :

English

Title :

Epstein-Barr virus and human herpesvirus 6 detection in a non-Hodgkin's diffuse large B-cell lymphoma cohort by using RNA sequencing.

Publication date :

2013

Journal title :

Journal of Virology

ISSN :

0022-538X

eISSN :

1098-5514

Publisher :

American Society for Microbiology, Washington, United States - District of Columbia

Volume :

Issue :

Pages :

13059-62

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 22 January 2018

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