Reference : Epstein-Barr virus and human herpesvirus 6 detection in a non-Hodgkin's diffuse large...
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
Epstein-Barr virus and human herpesvirus 6 detection in a non-Hodgkin's diffuse large B-cell lymphoma cohort by using RNA sequencing.
Strong, Michael J. [> >]
O'Grady, Tina mailto [Université de Liège - ULiège > Département des sciences de la vie > Génétique et biologie moléculaires animales >]
Lin, Zhen [> >]
Xu, Guorong [> >]
Baddoo, Melody [> >]
Parsons, Chris [> >]
Zhang, Kun [> >]
Taylor, Christopher M. [> >]
Flemington, Erik K. [> >]
Journal of Virology
Yes (verified by ORBi)
United States
[en] Cohort Studies ; Epstein-Barr Virus Infections/diagnosis/virology ; Gene Expression Regulation, Viral ; Herpesvirus 4, Human/genetics/isolation & purification ; Herpesvirus 6, Human/genetics/isolation & purification ; Humans ; Lymphoma, Large B-Cell, Diffuse/diagnosis/virology ; Roseolovirus Infections/diagnosis/virology ; Sequence Analysis, RNA ; Viral Proteins/genetics
[en] Comprehensive virome analysis of RNA sequence (RNA-seq) data sets from 118 non-Hodgkin's B-cell lymphomas revealed a small subset that is positive for Epstein-Barr virus (EBV) or human herpesvirus 6B (HHV-6B), with one coinfection. EBV transcriptome analysis revealed expression of the latency genes RPMS1, LMP1, and LMP2, with one sample additionally showing a high level of early lytic expression and another sample showing a high level of EBNA2 expression. HHV-6B transcriptome analysis revealed that the majority of genes were transcribed.

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