[en] Comprehensive virome analysis of RNA sequence (RNA-seq) data sets from 118 non-Hodgkin's B-cell lymphomas revealed a small subset that is positive for Epstein-Barr virus (EBV) or human herpesvirus 6B (HHV-6B), with one coinfection. EBV transcriptome analysis revealed expression of the latency genes RPMS1, LMP1, and LMP2, with one sample additionally showing a high level of early lytic expression and another sample showing a high level of EBNA2 expression. HHV-6B transcriptome analysis revealed that the majority of genes were transcribed.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Strong, Michael J.
O'Grady, Tina ; Université de Liège - ULiège > Département des sciences de la vie > Génétique et biologie moléculaires animales
Lin, Zhen
Xu, Guorong
Baddoo, Melody
Parsons, Chris
Zhang, Kun
Taylor, Christopher M.
Flemington, Erik K.
Language :
English
Title :
Epstein-Barr virus and human herpesvirus 6 detection in a non-Hodgkin's diffuse large B-cell lymphoma cohort by using RNA sequencing.
Publication date :
2013
Journal title :
Journal of Virology
ISSN :
0022-538X
eISSN :
1098-5514
Publisher :
American Society for Microbiology, Washington, United States - District of Columbia
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