[en] This review focuses on the role of the lung microbiome in idiopathic pulmonary fibrosis. Although historically considered sterile, bacterial communities have now been well documented in lungs both in healthy and pathological conditions. Studies in idiopathic pulmonary fibrosis (IPF) suggest that increased bacterial burden and/or abundance of potentially pathogenic bacteria may drive disease progression, acute exacerbations, and mortality. More recent work has highlighted the interaction between the lung microbiome and the innate immune system in IPF, strengthening the argument for the role of both host and environment interaction in disease pathogenesis. Existing published data suggesting that the lung microbiome may represent a therapeutic target, via antibiotic administration, immunization against pathogenic organisms, or treatment directed at gastroesophageal reflux. Taken altogether, published literature suggests that the lung microbiome might serve in the future as a prognostic biomarker, a therapeutic target, and/or provide an explanation for disease pathogenesis in IPF.
Disciplines :
Microbiology Cardiovascular & respiratory systems
Author, co-author :
Fastrès, Aline ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux
Felice, Florence ; Université de Liège - ULiège > Master méd. (ex 4e master en 4 ans)
Roels, Elodie ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux
MOERMANS, Catherine ; Centre Hospitalier Universitaire de Liège - CHU > Service de pneumologie - allergologie
CORHAY, Jean-Louis ; Centre Hospitalier Universitaire de Liège - CHU > Service de pneumologie - allergologie
Bureau, Fabrice ; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire
Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Clercx, Cécile ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux
GUIOT, Julien ; Centre Hospitalier Universitaire de Liège - CHU > Service de pneumologie - allergologie
Language :
English
Title :
The lung microbiome in idiopathic pulmonary fibrosis: A promising approach for targeted therapies
Publication date :
16 December 2017
Journal title :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Publisher :
Molecular Diversity Preservation International (MDPI), Basel, Switzerland
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