Article (Scientific journals)
HIV Latency: Should We Shock or Lock?
DARCIS, Gilles; Van Driessche, B.; Van Lint, C.
2017In Trends in Immunology, 38 (3), p. 217-228
Peer Reviewed verified by ORBi
 

Files


Full Text
trends.pdf
Publisher postprint (2.24 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Human immunodeficiency virus 1; Human immunodeficiency virus 1 infection; Review; CD4+ T lymphocyte; Human immunodeficiency virus infection; Animals; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; Chronic Disease; Epigenesis, Genetic; Gene Expression Regulation, Viral; HIV Infections; HIV-1; Humans; Molecular Targeted Therapy; NF-kappa B; Recurrence; Virus Activation; Virus Latency; Virus Replication
Abstract :
[en] Combinatory antiretroviral therapy (cART) increases the survival and quality of life of HIV-1-infected patients. However, interruption of therapy almost invariably leads to the re-emergence of detectable viral replication because HIV-1 persists in viral latent reservoirs. Improved understanding of the molecular mechanisms involved in HIV-1 latency has paved the way for innovative strategies that attempt to purge latent virus. In this article we discuss the results of the broadly explored ‘shock and kill’ strategy, and also highlight the major hurdles facing this approach. Finally, we present recent innovative works suggesting that locking out latent proviruses could be a potential alternative therapeutic strategy. © 2016 Elsevier Ltd
Disciplines :
Immunology & infectious disease
Author, co-author :
DARCIS, Gilles ;  Centre Hospitalier Universitaire de Liège - CHU > Service des maladies infectieuses - médecine interne
Van Driessche, B.;  Service of Molecular Virology, Département de Biologie Moléculaire (DBM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, Gosselies, Belgium
Van Lint, C.;  Service of Molecular Virology, Département de Biologie Moléculaire (DBM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, Gosselies, Belgium
Language :
English
Title :
HIV Latency: Should We Shock or Lock?
Publication date :
2017
Journal title :
Trends in Immunology
ISSN :
1471-4906
eISSN :
1471-4981
Publisher :
Elsevier Ltd
Volume :
38
Issue :
3
Pages :
217-228
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 January 2018

Statistics


Number of views
78 (6 by ULiège)
Number of downloads
2 (2 by ULiège)

Scopus citations®
 
128
Scopus citations®
without self-citations
115
OpenCitations
 
123

Bibliography


Similar publications



Contact ORBi