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Poster (Scientific congresses and symposiums)
Intrinsic fMRI functional architecture differentiates single patients after severe brain injury
Demertzi, Athina; Antonopoulos, Georgios; Heine, Lizette et al.
201545th annual meeting of the Society for Neuroscience
 

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Abstract :
[en] Background: Resting state acquisitions are by definition appropriate to assess non-communicating subjects. We here assessed the clinical relevance of systems-level resting state fMRI in patients with disorders of consciousness with the aim to promote single-patient diagnostics. Methods: Seventy three patients in minimally conscious state (MCS), vegetative state/unresponsive wakefulness syndrome (VS/UWS) and coma were scanned in 3 different centers. The main analysis was performed on the dataset coming from one centre (Liège, 51 patients; 26 MCS, 19 VS/UWS, 6 coma; 16 traumatic, 32 non-traumatic, 3 mixed; 35 patients assessed >1 month post-insult) for whom the clinical diagnosis with the Coma Recovery Scale-Revised (CRS-R) was congruent with positron emission tomography scanning. Using a multiple-seed correlation approach, group-level functional connectivity was investigated for the default mode, frontoparietal, salience, auditory, sensorimotor and visual networks. Between-group inferential statistics and machine learning were used to identify each network’s capacity to discriminate between patients in MCS and VS/UWS. Data from 22 patients independently scanned in two other centres (Salzburg: 10 MCS, 5 VS/UWS; New York: 5 MCS, 1 VS/UWS, 1 emerged from MCS) were used to validate the classification with the indetified features. Results: CRS-R total scores correlated with key regions of each network reflecting their involvement in consciousness-related processes. Although all networks had a high discriminative capacity (>80%) for separating patients in MCS and VS/UWS, the auditory network was ranked the most highly. Specifically, bilateral auditory and visual cortices of the auditory network were more functionally connected in patients in MCS compared to VS/UWS. Connectivity values in these three regions discriminated congruently 20 out of 22 independently assessed patients. Conclusions: These findings highlight the significance of preserved multisensory integration and top-down processing in minimal consciousness which are seemingly supported by auditory-visual crossmodal connectivity, and promote the clinical utility of the resting paradigm for single-patient diagnostics.
Disciplines :
Neurology
Author, co-author :
Demertzi, Athina  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Antonopoulos, Georgios ;  Université de Liège - ULiège > GIGA : Coma Group
Heine, Lizette ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Voss, H. U
Crone, J.S
De Los Angeles, C
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Di Perri, Carol ;  Université de Liège - ULiège > GIGA : Coma Group
Gomez, F
VANHAUDENHUYSE, Audrey  ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'algologie - soins palliatifs
CHARLAND-VERVILLE, Vanessa ;  Centre Hospitalier Universitaire de Liège - CHU > Service de psychologie clinique et d'action sociale
Kronbichler, M
Trinka, E
Phillips, Christophe  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
TSHIBANDA, Luaba ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Soddu, Andrea ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Schiff, N.D.
Whitfield-Gabrieli, S
LAUREYS, Steven  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie
More authors (9 more) Less
Language :
English
Title :
Intrinsic fMRI functional architecture differentiates single patients after severe brain injury
Publication date :
2015
Event name :
45th annual meeting of the Society for Neuroscience
Event place :
Chicago, United States
Event date :
from 17-10-2015 to 21-10-2015
Audience :
International
Available on ORBi :
since 16 January 2018

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