Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: reply.

Delierneux, Céline; Donis, Nathalie; Servais, Laurence; Wéra, Odile; LANCELLOTTI, Patrizio; Oury, Cécile

doi:10.1111/jth.13876

Letter to the editor (Scientific journals)

Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: reply.

Delierneux, Céline; Donis, Nathalie; Servais, Laurence et al.

2017 • In Journal of Thrombosis and Haemostasis

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/218199

DOI
10.1111/jth.13876

PubMed
29052966

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Keywords :

CpG ODN; platelet activation

Abstract :

[en] We provide here a new set of data supporting the involvement of multiple platelet receptors in CpG ODN platelet activating effects. We observed some sequence-specific features of platelet responses to phosphorothioate-modified CpG ODNs types A, B, and C that could be useful for future development of safe therapeutic CpG ODNs. Additional investigations are needed in order to further delineate these sequence specificities, and to address the importance of higher-order structures, as well as of possible interactions with cofactors for the effects of CpG ODN on platelets.

Disciplines :

Hematology

Author, co-author :

Delierneux, Céline; Université de Liège - ULiège > GIGA-Cardiovascular Sciences

Donis, Nathalie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences

Servais, Laurence ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences

Wéra, Odile ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences

LANCELLOTTI, Patrizio ; Centre Hospitalier Universitaire de Liège - CHU > Service de cardiologie

Oury, Cécile ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences

Language :

English

Title :

Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: reply.

Publication date :

2017

Journal title :

Journal of Thrombosis and Haemostasis

ISSN :

1538-7933

eISSN :

1538-7836

Publisher :

Wiley Online

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 January 2018

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