Letter to the editor (Scientific journals)
Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: reply.
Delierneux, Céline; Donis, Nathalie; Servais, Laurence et al.
2017In Journal of Thrombosis and Haemostasis
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Keywords :
CpG ODN; platelet activation
Abstract :
[en] We provide here a new set of data supporting the involvement of multiple platelet receptors in CpG ODN platelet activating effects. We observed some sequence-specific features of platelet responses to phosphorothioate-modified CpG ODNs types A, B, and C that could be useful for future development of safe therapeutic CpG ODNs. Additional investigations are needed in order to further delineate these sequence specificities, and to address the importance of higher-order structures, as well as of possible interactions with cofactors for the effects of CpG ODN on platelets.
Disciplines :
Hematology
Author, co-author :
Delierneux, Céline;  Université de Liège - ULiège > GIGA-Cardiovascular Sciences
Donis, Nathalie ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences
Servais, Laurence ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences
Wéra, Odile ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences
LANCELLOTTI, Patrizio  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de cardiologie
Oury, Cécile  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences
Language :
English
Title :
Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: reply.
Publication date :
2017
Journal title :
Journal of Thrombosis and Haemostasis
ISSN :
1538-7933
eISSN :
1538-7836
Publisher :
Wiley Online
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 January 2018

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