[en] The present invention provides polyplex comprising: (a) at least one polymer of formula (I) comprising at least one set of repeating units of formula: and wherein for each set of repeating units R 1 represents either a hydrogen atom or a straight or branched chain alkyl group having from 1 to 20 carbon atoms and R 2 represents a straight or branched chain alkyl group having from 1 to 20 carbon atoms, wherein n and m each represent an integer of from 1 to 5000, wherein the sum of n and m is from 10 to 250 when R 1 represents a hydrogen atom and when the polymer of formula (I) contains only one set of repeating units; and (b) at least one nucleic acid having improved transfection efficient and reduced cytotoxicity; a method for preparing a polyplex; a method for preparing the polymer of formula (I) for use in the polyplex; a method for transferring at least one nucleic acid into a cell and a pharmaceutical composition comprising the polyplex and an adjuvant; use of a polyplex or of a pharmaceutical composition according to the invention in transferring at least one nucleic acid into a cell; and use of a polymer of formula (I) as defined above in transferring of at least one nucleic acid into a cell.. To be accompanied when published by Figure 1 of the accompanying drawings.
Research Center/Unit :
CESAM Complex and Entangled Systems from Atoms to Materials (CESAM) Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering Chemistry
Inventor :
Debuigne, Antoine ; University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Dréan, Mathilde; University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM) > University Pierre et Marie Curie, Institut Parisien de Chimie Moléculaire, Team "Chimie des Polymères" (LCP) Paris, France
Guégan, Philippe; University Pierre et Marie Curie, Institut Parisien de Chimie Moléculaire, Team "Chimie des Polymères" (LCP) Paris, France
Jérôme, Christine ; University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Midoux, Patric; University Pierre et Marie Curie, Institut Parisien de Chimie Moléculaire, Team "Chimie des Polymères" (LCP) Paris, France
Rieger, Jutta; University Pierre et Marie Curie, Institut Parisien de Chimie Moléculaire, Team "Chimie des Polymères" (LCP) Paris, France
Language :
English
Title (54) :
Improvement in or relating to organic material
Publication date (43-45) :
25 October 2017
Filing date (22) :
20 April 2016
Patent/publication number (10-11) :
EP 3235513
Patent status (13) :
A
Priority number (30) :
EP20160165764 20160418
International classification (IPC) (51) :
A61K47/50; A61K48/00; C12N15/87
European classification (ECLA) (52) :
-
Applicant (71) :
University of Liège (ULiège), Université Pierre et Marie-Curie (Paris), French "Centre National de la Recherche Scientifique" (CNRS)
