Reference : Improvement in or relating to organic material
Patent : Patent
Engineering, computing & technology : Materials science & engineering
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/218045
Improvement in or relating to organic material
English
Debuigne, Antoine mailto [University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM) > > > >]
Dréan, Mathilde [University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM) > University Pierre et Marie Curie, Institut Parisien de Chimie Moléculaire, Team "Chimie des Polymères" (LCP) Paris, France > > >]
Guégan, Philippe [University Pierre et Marie Curie, Institut Parisien de Chimie Moléculaire, Team "Chimie des Polymères" (LCP) Paris, France > > > >]
Jérôme, Christine mailto [University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM) > > > >]
Midoux, Patric [University Pierre et Marie Curie, Institut Parisien de Chimie Moléculaire, Team "Chimie des Polymères" (LCP) Paris, France > > > >]
Rieger, Jutta [University Pierre et Marie Curie, Institut Parisien de Chimie Moléculaire, Team "Chimie des Polymères" (LCP) Paris, France > > > >]
25-Oct-2017
2016-04-20
European Patent Office
EP 3235513
EP20160165764 20160418
A
Europe
University of Liège (ULiège), Université Pierre et Marie-Curie (Paris), French "Centre National de la Recherche Scientifique" (CNRS)
A61K47/50; A61K48/00; C12N15/87
-
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
[en] The present invention provides polyplex comprising: (a) at least one polymer of formula (I) comprising at least one set of repeating units of formula: and wherein for each set of repeating units R 1 represents either a hydrogen atom or a straight or branched chain alkyl group having from 1 to 20 carbon atoms and R 2 represents a straight or branched chain alkyl group having from 1 to 20 carbon atoms, wherein n and m each represent an integer of from 1 to 5000, wherein the sum of n and m is from 10 to 250 when R 1 represents a hydrogen atom and when the polymer of formula (I) contains only one set of repeating units; and (b) at least one nucleic acid having improved transfection efficient and reduced cytotoxicity; a method for preparing a polyplex; a method for preparing the polymer of formula (I) for use in the polyplex; a method for transferring at least one nucleic acid into a cell and a pharmaceutical composition comprising the polyplex and an adjuvant; use of a polyplex or of a pharmaceutical composition according to the invention in transferring at least one nucleic acid into a cell; and use of a polymer of formula (I) as defined above in transferring of at least one nucleic acid into a cell.. To be accompanied when published by Figure 1 of the accompanying drawings.
CESAM Complex and Entangled Systems from Atoms to Materials (CESAM) ; Center for Education and Research on Macromolecules (CERM)
Researchers
http://hdl.handle.net/2268/218045

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