Reference : Differential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell p...
Scientific journals : Article
Human health sciences : Pediatrics
Human health sciences : Hematology
http://hdl.handle.net/2268/217507
Differential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell precursor acute lymphoblastic leukaemia: results of the EORTC CLG 58881 and 58951 trials
English
Piette, Caroline mailto [Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Service Universitaire de Pédiatrie ULiège > Hémato-Oncologie Pédiatrique > >]
Suciu, S [> >]
Clappier, E [> >]
Bertrand, Y [> >]
Drunat, S [> >]
Girard, S [> >]
Yacouben, K [> >]
Plat, G [> >]
Dastugue, N [> >]
Mazingue, F [> >]
Grardel, N [> >]
Van Roy, N [> >]
Uyttebroeck, A [> >]
Costa, V [> >]
Minckes, O [> >]
Sirvent, N [> >]
Simon, P [> >]
Lutz, P [> >]
Ferster, A [> >]
Pluchart, C [> >]
Poirée, M [> >]
Freycon, C [> >]
Dresse, Marie-Françoise mailto [Centre Hospitalier Universitaire de Liège - CHU > Hémato-Oncologie Pédiatrique > Service de pédiatrie (CHR) > > > >]
Millot, F [> >]
Chantrain, C [> >]
van der Werff Ten Bosch, J [> >]
Norga, K [> >]
Gilotay, C [> >]
Rohrlich, PS [> >]
Benoit, Y [> >]
Cavé, H [> >]
2018
Leukemia
Nature Publishing Group
32
244-248
Yes (verified by ORBi)
International
0887-6924
1476-5551
London
United Kingdom
[en] In childhood B-cell precursor acute lymphoblastic leukaemias (BCP-ALL), the presence of an ETV6-RUNX1 fusion transcript defines one of the most prevalent genetic subgroups, together with the high hyperdiploidy (HeH) ALL. Although ETV6-RUNX1pos ALLs are associated with favourable outcome, their proper treatment strategies remain debatable, some groups suggesting crucial impact of upfront intensive treatment while others favour low-intensity antimetabolite-based therapy.
Professionals
http://hdl.handle.net/2268/217507
10.1038/leu.2017.289

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