Article (Scientific journals)
The minor collagens in articular cartilage
Luo, Y.; Sinkeviciute, D.; He, Y. et al.
2017In Protein and Cell, 8 (8), p. 560-572
Peer Reviewed verified by ORBi
 

Files


Full Text
13238_2017_Article_377.pdf
Publisher postprint (662.98 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Review; Stickler syndrome; Aggrecans; Animals; Biomarkers; Cartilage, Articular; Collagen; Extracellular Matrix Proteins; Gene Expression; Humans; Osteoarthritis; Protein Isoforms
Abstract :
[en] Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions. Genetic studies of these minor collagens have revealed that they are associated with multiple connective tissue diseases, especially degenerative joint disease. The progressive destruction of cartilage involves the degradation of matrix constituents including these minor collagens. The generation and release of fragmented molecules could generate novel biochemical markers with the capacity to monitor disease progression, facilitate drug development and add to the existing toolbox for in vitro studies, preclinical research and clinical trials. © 2017, The Author(s).
Disciplines :
Rheumatology
Author, co-author :
Luo, Y.;  Biomarkers & Research, Nordic Bioscience A/S, Herlev, Denmark, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Sinkeviciute, D.;  Biomarkers & Research, Nordic Bioscience A/S, Herlev, Denmark, Department of Clinical Sciences, Medical Faculty, Lund University, Lund, Sweden
He, Y.;  Biomarkers & Research, Nordic Bioscience A/S, Herlev, Denmark
Karsdal, M.;  Biomarkers & Research, Nordic Bioscience A/S, Herlev, Denmark
Henrotin, Yves  ;  Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)
Mobasheri, A.;  Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, United Kingdom, Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, Arthritis Research UK Centre for Musculoskeletal Ageing Research, Queen’s Medical Centre, Nottingham, NG7 2UH, United Kingdom
Önnerfjord, P.;  Department of Clinical Sciences, Medical Faculty, Lund University, Lund, Sweden
Bay-Jensen, A.;  Biomarkers & Research, Nordic Bioscience A/S, Herlev, Denmark
Title :
The minor collagens in articular cartilage
Publication date :
2017
Journal title :
Protein and Cell
ISSN :
1674-800X
eISSN :
1674-8018
Publisher :
Higher Education Press
Volume :
8
Issue :
8
Pages :
560-572
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
FP7 - 305815 - D-BOARD - Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases
Funders :
CE - Commission Européenne [BE]
Available on ORBi :
since 19 December 2017

Statistics


Number of views
79 (4 by ULiège)
Number of downloads
133 (3 by ULiège)

Scopus citations®
 
173
Scopus citations®
without self-citations
161
OpenCitations
 
138

Bibliography


Similar publications



Contact ORBi