Article (Scientific journals)
FDG PET/CT radiomics for predicting the outcome of locally advanced rectal cancer.
LOVINFOSSE, Pierre; POLUS, Marc; VAN DAELE, Daniel et al.
2018In European Journal of Nuclear Medicine and Molecular Imaging
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Keywords :
18F-FDG PET/CT; Radiomics; Rectal cancer; Textural analysis; Tumor heterogeneity
Abstract :
[en] PURPOSE: The aim of this study was to investigate the prognostic value of baseline 18F-FDG PET/CT textural analysis in locally-advanced rectal cancer (LARC). METHODS: Eighty-six patients with LARC underwent 18F-FDG PET/CT before treatment. Maximum and mean standard uptake values (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), histogram-intensity features, as well as 11 local and regional textural features, were evaluated. The relationships of clinical, pathological and PET-derived metabolic parameters with disease-specific survival (DSS), disease-free survival (DFS) and overall survival (OS) were assessed by Cox regression analysis. Logistic regression was used to predict the pathological response by the Dworak tumor regression grade (TRG) in the 66 patients treated with neoadjuvant chemoradiotherapy (nCRT). RESULTS: The median follow-up of patients was 41 months. Seventeen patients (19.7%) had recurrent disease and 18 (20.9 %) died, either due to cancer progression (n = 10) or from another cause while in complete remission (n = 8). DSS was 95% at 1 year, 93% at 2 years and 87% at 4 years. Weight loss, surgery and the texture parameter coarseness were significantly associated with DSS in multivariate analyses. DFS was 94 % at 1 year, 86 % at 2 years and 79 % at 4 years. From a multivariate standpoint, tumoral differentiation and the texture parameters homogeneity and coarseness were significantly associated with DFS. OS was 93% at 1 year, 87% at 2 years and 79% after 4 years. cT, surgery, SUVmean, dissimilarity and contrast from the neighborhood intensity-difference matrix (contrastNGTDM) were significantly and independently associated with OS. Finally, RAS-mutational status (KRAS and NRAS mutations) and TLG were significant predictors of pathological response to nCRT (TRG 3-4). CONCLUSION: Textural analysis of baseline 18F-FDG PET/CT provides strong independent predictors of survival in patients with LARC, with better predictive power than intensity- and volume-based parameters. The utility of such features, especially coarseness, should be confirmed by larger clinical studies before considering their potential integration into decisional algorithms aimed at personalized medicine.
Disciplines :
Genetics & genetic processes
Author, co-author :
LOVINFOSSE, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de médecine nucléaire et imagerie onco
POLUS, Marc ;  Centre Hospitalier Universitaire de Liège - CHU > Service de gastroentérologie, hépatologie, onco. digestive
VAN DAELE, Daniel ;  Centre Hospitalier Universitaire de Liège - CHU > Service de gastroentérologie, hépatologie, onco. digestive
Martinive, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
DAENEN, Frédéric ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Hatt, Mathieu
Visvikis, Dimitris
KOOPMANSCH, Benjamin ;  Centre Hospitalier Universitaire de Liège - CHU > Service de génétique
LAMBERT, Frédéric ;  Centre Hospitalier Universitaire de Liège - CHU > Service de génétique
COIMBRA MARQUES, Carla ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdo, sénologique, endocrine et de transplantation
SEIDEL, Laurence  ;  Centre Hospitalier Universitaire de Liège - CHU > Service des informations médico économiques (SIME)
Albert, Adelin  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Hustinx, Roland  ;  Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire
More authors (4 more) Less
Language :
English
Title :
FDG PET/CT radiomics for predicting the outcome of locally advanced rectal cancer.
Publication date :
2018
Journal title :
European Journal of Nuclear Medicine and Molecular Imaging
ISSN :
1619-7070
eISSN :
1619-7089
Publisher :
Springer, Germany
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 November 2017

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