Article (Scientific journals)
Cibler la voie métabolique du cortisol comme action thérapeutique dans le diabète de type 2
Scheen, André
2016In Médecine des Maladies Métaboliques, 10 (8), p. 725-731
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Keywords :
Cortisol; Article; Cushing syndrome
Abstract :
[en] The 11ß-hydroxysteroid dehydrogenase type 1 (11βHSD1) enzyme promotes the local conversion from inactive cortisone to active cortisol. It may play a role in the pathophysiology of abdominal obesity and the metabolic syndrome, both showing some similarities with the Cushing syndrome. Synthetic selective inhibitors of 11βHSD1 have been investigated in pilot studies in overweight/obese patients with type 2 diabetes or hypertension. Although some positive effects were observed, they were considered as too modest compared to what could be obtained with other available drugs. More recently, a reduction in liver steatosis was reported in overweight/obese non-diabetic patients. Whereas some early 11βHSD1 inhibitors have been abandoned, others are still in development, which demonstrates a persisting interest for this innovative therapeutic approach. © 2016 Elsevier Masson SAS
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Title :
Cibler la voie métabolique du cortisol comme action thérapeutique dans le diabète de type 2
Alternative titles :
[en] Targeting the metabolic pathway of cortisol as a potential therapy of type 2 diabetes
Publication date :
2016
Journal title :
Médecine des Maladies Métaboliques
ISSN :
1957-2557
eISSN :
2214-8477
Publisher :
Elsevier Masson SAS
Volume :
10
Issue :
8
Pages :
725-731
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 November 2017

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