Abolmaali, S.S., Tamaddon, A.M., Dinarvand, R., A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis. Cancer Chemother. Pharmacol. 71 (2013), 1115–1130.
Almeida, A., Silva, D., Gonçalves, V., Sarmento, B., Synthesis and characterization of chitosan-grafted-polycaprolactone micelles for modulate intestinal paclitaxel delivery. Drug Deliv. Transl. Res., 2017, 1–11.
Andrews, G.P., Laverty, T.P., Jones, D.S., Mucoadhesive polymeric platforms for controlled drug delivery. Eur. J. Pharm. Biopharm. 71 (2009), 505–518.
Antunes, F., Andrade, F., Araujo, F., Ferreira, D., Sarmento, B., Establishment of a triple co-culture in vitro cell models to study intestinal absorption of peptide drugs. Eur. J. Pharm. Biopharm. 83 (2013), 427–435.
Araujo, F., Sarmento, B., Towards the characterization of an in vitro triple co-culture intestine cell model for permeability studies. Int. J. Pharm. 458 (2013), 128–134.
Asane, G.S., Nirmal, S.A., Rasal, K.B., Naik, A.A., Mahadik, M.S., Rao, Y.M., Polymers for mucoadhesive drug delivery system: a current status. Drug Dev. Ind. Pharm. 34 (2008), 1246–1266.
Barrueco, J.R., O'Leary, D.F., Sirotnak, F.M., Metabolic turnover of methotrexate polyglutamates in lysosomes derived from S180 cells. Definition of a two-step process limited by mediated lysosomal permeation of polyglutamates and activating reduced sulfhydryl compounds. J. Biol. Chem. 267 (1992), 15356–15361.
Becker, L.C., Bergfeld, W.F., Belsito, D.V., Klaassen, C.D., Marks, J.G., Shank, R.C., Slaga, T.J., Snyder, P.W., Andersen, F.A., Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate. Int. J. Toxicol. 28 (2009), 5–67.
Boni, F.I., Prezotti, F.G., Cury, B.S., Gellan gum microspheres crosslinked with trivalent ion: effect of polymer and crosslinker concentrations on drug release and mucoadhesive properties. Drug Dev. Ind. Pharm. 42 (2016), 1283–1290.
Borst, P., Evers, R., Kool, M., Wijnholds, J., The multidrug resistance protein family. Biochim. Biophys. Acta 1461 (1999), 347–357.
Carvalho, F.C., Bruschi, M.L., Evangelista, R.C., Gremião, M.P.D., Mucoadhesive drug delivery systems. Braz. J. Pharm. Sci. 46 (2010), 1–17.
Carvalho, F.C., Calixto, G., Hatakeyama, I.N., Luz, G.M., Gremião, M.P., Chorilli, M., Rheological, mechanical and bioadhesive behavior of hydrogels to optimize skin delivery systems. Drug Dev. Ind. Pharm. 39 (2013), 1750–1757.
Cascone, M.G., Lazzeri, L., Carmignani, C., Zhu, Z., Gelatin nanoparticles produced by a simple W/O emulsion as delivery system for methotrexate. J. Mater. Sci. Mater. Med. 13 (2002), 523–526.
Chadha, R., Arora, P., Kaur, R., Saini, A., Singla, M., Jain, D., Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques. Acta Pharma. 59 (2009), 245–257.
Chae, S.Y., Jang, M.K., Nah, J.W., Influence of molecular weight on oral absorption of water soluble chitosans. J. Control. Release 102 (2005), 383–394.
Ensign, L.M., Schneider, C., Suk, J.S., Cone, R., Hanes, J., Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery. Adv. Mater. 24 (2012), 3887–3894.
Ferreira, N.N., Perez, T.A., Pedreiro, L.N., Prezotti, F.G., Boni, F.I., Cardoso, V.M.D.O., Venâncio, T., Gremião, M.P.D., A novel pH-responsive hydrogel based on calcium alginate engineered by the previous formation of polyelectrolyte complexes (PECs) intended to vaginal administration. Drug Dev. Ind. Pharm., 2017, 1–33.
Fukasawa, M., Obara, S., Molecular weight determination of hypromellose phthalate (HPMCP) using size exclusion chromatography with a multi-angle laser light scattering detector. Chem. Pharm. Bull. (Tokyo) 51 (2003), 1304–1306.
Gaies, E., Jebabli, N., Trabelsi, S., Salouage, I., Charfi, R., Lakhal, M., Klouz, A., Methotrexate side effects: review article. J. Drug. Metab. Toxicol. 3 (2012), 1–5.
Gamboa, J.M., Leong, K.W., In vitro and in vivo models for the study of oral delivery of nanoparticles. Adv. Drug Deliv. Rev. 65 (2013), 800–810.
Gao, H., Yang, W., Min, K., Zha, L., Wang, C., Fu, S., Thermosensitive poly(N-isopropylacrylamide) nanocapsules with controlled permeability. Polymer 46 (2005), 1087–1093.
Gaumet, M., Vargas, A., Gurny, R., Delie, F., Nanoparticles for drug delivery: the need for precision in reporting particle size parameters. Eur. J. Pharm. Biopharm. 69 (2008), 1–9.
Gorlick, R., Goker, E., Trippett, T., Steinherz, P., Elisseyeff, Y., Mazumdar, M., Flintoff, W.F., Bertino, J.R., Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression. Blood 89 (1997), 1013–1018.
Hamidi, M., Azadi, A., Rafiei, P., Hydrogel nanoparticles in drug delivery. Adv. Drug Deliv. Rev. 60 (2008), 1638–1649.
Haxaire, K., Maréchal, Y., Milas, M., Rinaudo, M., Hydration of polysaccharide hyaluronan observed by IR spectrometry. I. preliminary experiments and band assignments. Biopolymers 72 (2003), 10–20.
Higano, C.S., Livingston, R.B., Oral dipyridamole and methotrexate in human solid tumors: a toxicity trial. Cancer Chemother. Pharmacol. 23 (1989), 259–262.
Hokputsaa, S., Jumel, K., Alexander, C., Harding, S.E., Hydrodynamic characterisation of chemically degraded hyaluronic acid. Carbohydr. Polym. 52 (2003), 111–117.
Huber, P.C., Maruiama, C.H., Almeida, W.P., P-glycoprotein and multidrug resistance: structure-activity relationships of modulators. Quim Nova 33 (2010), 2148–2154.
Jachens, A.W., Chu, D.S., Retrospective review of methotrexate therapy in the treatment of chronic, noninfectious, nonnecrotizing scleritis. Am J. Ophthalmol. 145 (2008), 487–492.
Jain, R.K., Wei, J., Gullino, P.M., Pharmacokinetics of methotrexate in solid tumors. J. Pharmacokinet. Biopharm. 7 (1979), 181–194.
Janes, K.A., Calvo, P., Alonso, M.J., Polysaccharide colloidal particles as delivery systems for macromolecules. Adv. Drug Deliv. Rev. 47 (2001), 83–97.
Leonard, F., Collnot, E.M., Lehr, C.M., A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro. Mol. Pharm. 7 (2010), 2103–2119.
Li, C., Hein, S., Wang, K., Chitosan-carrageenan polyelectrolyte complex for the delivery of protein drugs. ISRN Biomaterials 2013 (2013), 1–6.
Liao, Y.-H., Jones, S.A., Forbes, B., Martin, G.P., Brown, M.B., Hyaluronan: pharmaceutical characterization and drug delivery. Drug Deliv. 12 (2005), 327–342.
Madsen, F., Eberth, K., Smart, J.D., A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration. J. Control. Release 50 (1998), 167–178.
Makhlof, A., Tozuka, Y., Takeuchi, H., Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. Eur. J. Pharm. Sci. 42 (2011), 445–451.
Martins, S.J., Yamamoto, C.A., Clinical and economic issues in adjuvant chemotherapy for HER-2 positive breast cancer. Rev. Assoc. Med. Bras. 54 (2008), 494–499.
Meehan, E., Characterisation of hydroxypropylmethylcellulose phthalate (HPMCP) by GPC using a modified organic solvent. Anal. Chim. Acta 557 (2006), 2–6.
Meera, G.T., Abraham, E., Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan — a review. J. Control. Release 114 (2006), 1–14.
Mizrahy, S., Raz, S.R., Hasgaard, M., Liu, H., Soffer-Tsur, N., Cohen, K., Dvash, R., Landsman-Milo, D., Bremer, M.G.E.G., Moghimi, S.M., Peer, D., Hyaluronan-coated nanoparticles: the influence of the molecular weight on CD44-hyaluronan interactions and on the immune response. J. Control. Release 156 (2011), 231–238.
Murphy, R.M., Static and dynamic light scattering of biological macromolecules: what can we learn?. Curr. Opin. Biotechnol. 8 (1997), 25–30.
Pedreiro, L.N., Stringhetti, B., Cury, F., Gremião, M.P., Mucoadhesive nanostructured polyelectrolyte complexes as potential carrier to improve zidovudine permeability. J. Nanosci. Nanotechnol. 16 (2016), 1248–1256.
Reddy, K.J., Karunakaran, K.T., Purification and characterization of hyaluronic acid produced by Streptococcus zooepidemicus strain 3523-7. J. BioSci. Biotech. 2 (2013), 173–179.
Rinaudo, M., Chitin and chitosan: properties and applications. Prog. Polym. Sci. 31 (2011), 603–632.
Sarmento, B., Ribeiro, A., Veiga, F., Sampaio, P., Neufeld, R., Ferreira, D., Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm. Res. 24 (2007), 2198–2206.
Schatz, C., Pichot, C., Delair, T., Viton, C.D., Static lights studies on chitosan solutions: from macromolecular chains to colloidal dispersions. Langmuir 19 (2003), 9896–9903.
Schatz, C., Domard, A., Viton, C., Pichot, C., Delair, T., Versatile and efficient formation of colloids of biopolymer-based polyelectrolyte complexes. Biomacromolecules 5 (2004), 1882–1892.
Shah, P., Jogani, V., Bagchi, T., Misra, A., Role of Caco-2 cell monolayers in prediction of intestinal drug absorption. Biotechnol. Prog. 22 (2006), 186–198.
Shrestha, N., Araújo, F., Shahbazi, M.-A., Mäkilä, E., Gomes, M.J., Herranz-Blanco, B., Lindgren, R., Granroth, S., Kukk, E., Salonen, J., Hirvonen, J., Sarmento, B., Santos, H.A., Thiolation and cell-penetrating peptide surface functionalization of porous silicon nanoparticles for oral delivery of insulin. Adv. Funct. Mater. 26 (2016), 3405–3416.
Silva, D.S., Almeida, A., Prezotti, F., Cury, B., Campana-Filho, S.P., Sarmento, B., Synthesis and characterization of 3,6-O,O′-dimyristoyl chitosan micelles for oral delivery of paclitaxel. Colloid. Surface. B. 152 (2017), 220–228.
Smart, J.D., The basics and underlying mechanisms of mucoadhesion. Adv. Drug Deliv. Rev. 57 (2005), 1556–1568.
Sosnik, A., Das Neves, J., Sarmento, B., Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review. Prog. Polym. Sci. 39 (2014), 2030–2075.
Thanou, M., Verhoef, J., Junginger, H., Oral drug absorption enhancement by chitosan and its derivatives. Adv. Drug Deliv. Rev. 52 (2001), 117–126.
Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M.M., Pastan, I., Willingham, M.C., Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. U. S. A. 84 (1987), 7735–7738.
Trapani, A., Denora, N., Iacobellis, G., Sitterberg, J., Bakowsky, U., Kissel, T., Methotrexate-loaded chitosan- and glycol chitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors. AAPS PharmSciTech 12 (2011), 1302–1311.
Valente, J.J., Payne, R.W., Manning, M.C., Wilson, W.W., Henry, C.S., Colloidal behavior of proteins: effects of the second virial coefficient on solubility, crystallization and aggregation of proteins in aqueous solution. Curr. Pharm. Biotechnol. 6 (2005), 427–436.
Varum, F.O., Basit, A.W., Sousa, J., Veiga, F., Mucoadhesion studies in the gastrointestinal tract to increase oral drug bioavailability. Braz. J. Pharm. Sci. 44 (2008), 535–547.
Varum, F.J., Veiga, F., Sousa, J.S., Basit, A.W., An investigation into the role of mucus thickness on mucoadhesion in the gastrointestinal tract of pig. Eur. J. Pharm. Sci. 40 (2010), 335–341.
Vllasaliu, D., Exposito-Harris, R., Heras, A., Casettari, L., Garnett, M., Illum, L., Stolnik, S., Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution. Int. J. Pharm. 400 (2010), 183–193.
Wang, X.Q., Dai, J.D., Chen, Z., Zhang, T., Xia, G.M., Nagai, T., Zhang, Q., Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration. J. Control. Release 97 (2004), 421–429.
Wang, A.Z., Langer, R., Farokhzad, O.C., Nanoparticle delivery of cancer drugs. Annu. Rev. Med. 63 (2012), 185–198.
Wang, J., Kong, M., Zhou, Z., Yan, D., Yu, X., Cheng, X., Feng, C., Liu, Y., Chen, X., Mechanism of surface charge triggered intestinal epithelial tight junction opening upon chitosan nanoparticles for insulin oral delivery. Carbohydr. Polym. 157 (2017), 596–602.
Yang, Y., Wang, S., Wang, Y., Wang, X., Wang, Q., Chen, M., Advances in self-assembled chitosan nanomaterials for drug delivery. Biotechnol. Adv. 32 (2014), 1301–1316.
Yeh, T.-H., Hsu, L.-W., Tseng, M.T., Lee, P.-L., Sonjae, K., Ho, Y.-C., Sung, H.-W., Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening. Biomaterials 32 (2011), 6164–6173.
Zhang, X., Sun, M., Zheng, A., Cao, D., Bi, Y., Sun, J., Preparation and characterization of insulin-loaded bioadhesive PLGA nanoparticles for oral administration. Eur. J. Pharm. Sci. 45 (2012), 632–638.