Protection cardiovasculaire du patient diabetique de type 2 : d'EMPA-REG OUTCOME a LEADER.

[en] Two clinical trials demonstrate the superiority versus a placebo of two antidiabetic drugs in patients with type 2 diabetes and high cardiovascular risk. Empagliflozin, an inhibitor of sodium-glucose type 2 (SGLT2) cotransporters, in EMPA-REG OUTCOME, and liraglutide, an agonist of glucagon-like peptide-1 (GLP-1) receptors, in LEADER, showed a significant reduction in major cardiovascular events (- 14 and - 13 %, respectively), cardiovascular mortality (- 38 and - 22 %, respectively) and all-cause mortality (- 32 and - 15 %, respectively). A lower progression of kidney disease and less renal events were also reported. The underlying protective mechanisms remain controverted as the discussion whether the benefits are specific to each medication or could be extended to other molecules of these two pharmacological classes.

Disciplines :

Pharmacy, pharmacology & toxicology
Endocrinology, metabolism & nutrition

Author, co-author :

Scheen, André ; Université de Liège > Département des sciences cliniques > Département des sciences cliniques

WALLEMACQ, Caroline ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de diabétologie, nutrition, maladies métaboliques

Jandrain, Bernard ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de diabétologie, nutrition, maladies métaboliques

Ernest, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Pharmacologie clinique

Language :

French

Title :

Protection cardiovasculaire du patient diabetique de type 2 : d'EMPA-REG OUTCOME a LEADER.

Alternative titles :

[en] Cardiovascular protection of patients with type 2 diabetes : from EMPA-REG OUTCOME to LEADER

Publication date :

2016

Journal title :

Revue Médicale Suisse

ISSN :

1660-9379

Publisher :

Medecine et Hygiène, Switzerland

Volume :

Issue :

527

Pages :

1370-1375

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 September 2017

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Bibliography

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