Responders to platelet-rich plasma (PRP) in osteoarthritis: A technical analysis

[en] Purpose. To evaluate the similarities and differences between the variety of platelet-rich plasma (PRP) formulations, preparation, and uses to try to determine the best responses for the treatment of knee osteoarthritis. Materials and Methods. A comparison of the outcomes of randomized controlled trials (RCTs) included in the 3 most recent and high-quality meta-analyses to classify the different studies in 2 groups (bad responders group (BRG) and very good responders group (VGRG)). Results and Discussion. From the 19 RCTs analyzed, 7 trials were included in the VGRG and 4 in the BRG. In VGRG, 1 or 2 injections were performed in 4/7 trials, time between injections was 2 to 3 weeks in 4/5 studies with many injections, volume injected varied from 2.5 to 8 mL, and single spinning technique was used in 5/7 studies. PRP classification was Mishra 4B and PAWP2B𝛽 in 5/7 studies. The use of PRP with leukocytes is only found in the BRG. Conclusion. There is a lack of standardization in PRP preparation technique for knee osteoarthritis. However it appears that the use of a single spinning technique, a platelet concentration lower than 5 times the baseline, and avoidance of leukocytes should be preferred.

Disciplines :

Orthopedics, rehabilitation & sports medicine
Rheumatology
Laboratory medicine & medical technology
Pharmacy, pharmacology & toxicology

Author, co-author :

MILANTS, Christophe ; Centre Hospitalier Universitaire de Liège - CHU > Service de médecine de l'appareil locomoteur

Bruyère, Olivier ; Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Kaux, Jean-François ; Université de Liège > Département des sciences de la motricité > Médecine physique, réadaptation et traumatologie du sport

Language :

English

Title :

Responders to platelet-rich plasma (PRP) in osteoarthritis: A technical analysis

Publication date :

August 2017

Journal title :

BioMed Research International

ISSN :

2314-6133

eISSN :

2314-6141

Publisher :

Hindawi

Pages :

Article ID 7538604

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 28 August 2017

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76 (13 by ULiège)

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