[en] Objectives: High incidence of GBS sepsis has been reported in HIV-exposed but uninfected (HEU) infants in both developed and developing countries, particularly late-onset diseases. We aimed determining the prevalence, the characteristics and the risk factors of GBS carriage in HIV-infected and HIV uninfected pregnant women (PW).
Methods : Between 1/01/2011 and 31/12/2013, HIV-infected (n=132) and uninfected (n=123) PW had recto-vaginal swabs for GBS detection performed at 35-37 weeks of gestation and at deliver Demographic, obstetrical and medical data related to HIV-infection were prospectively collected. Serotyping of GBS strains was performed on a limited number of randomly selected samples (26 from HIV-infected and 13 from uninfected PW).
Results : The overall prevalence of GBS carriage was not statistically different between HIV-infected and uninfected PW (31% vs 24,4% respectively). Age, nadir CD4 cell count, CD4 cell count at delivery and detectable viral load at delivery were not associated with GBS carriage rate in HIV-infected PW. A distinct pattern of GBS serotype was found in HIV-infected PW who were predomina colonized by serotype III (12/26) while HIV-uninfected PW were mostly colonized by serotype Ia (8/13) (p<0,05).
Conclusions: As previously reported in other countries, HIV-infected PW do not have significantly higher rate of GBS colonization. However, our results suggest that HIV-infected PW are more lik be colonized with serotype III strains, that is the main serotype associated with late-onset neonatal sepsis. Ongoing research aims at characterizing the clonal features of the isolated strains
Research Center/Unit :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics) Pediatrics Laboratory medicine & medical technology Immunology & infectious disease
Author, co-author :
DAUBY, Nicolas; CHU Saint-Pierre Université Libre de Bruxelles (ULB), Brussels, Belgium > Department of Infectious Diseases
ADLER, Catherine; Centre Hospitalier Universitaire Saint-Pierre (Bruxelles) - CHU St-Pierre > Department of Pediatrics
Y MIENDJE DEYI, Véronique; Pôle Hospitalier Universitaire de Bruxelles (PHUB), Brussels, Belgium > LHUB-ULB Microbiology Department
BUSSON, Laurent; Pôle Hospitalier Universitaire de Bruxelles (PHUB), Brussels, Belgium > LHUB-ULB Microbiology Department
CHAMEKH, Mustapha; Université Libre de Bruxelles, Gosselies, Belgium > Institute for Medical Immunology (IMI)
DELFORGE, Marc; Pôle Hospitalier Universitaire de Bruxelles (PHUB), Brussels, Belgium > LHUB-ULB Microbiology Department
MARCHANT, Arnaud; Université Libre de Bruxelles, Gosselies, Belgium > Institute for Medical Immunology (IMI)
BARLOW, Patricia; Centre Hospitalier Universitaire Saint-Pierre (Bruxelles) - CHU St-Pierre > Obstetric Department
DE WIT, Stéphane; CHU Saint-Pierre Université Libre de Bruxelles (ULB), Brussels, Belgium > Department of Infectious Diseases
LEVY, Jack; Centre Hospitalier Universitaire Saint-Pierre (Bruxelles) - CHU St-Pierre > Department of Pediatrics
Melin, Pierrette ; Université de Liège > Département des sciences biomédicales et précliniques > Bactériologie, mycologie, parasitologie, virologie
GOETGHEBUER, Tessa; Centre Hospitalier Universitaire Saint-Pierre (Bruxelles) - CHU St-Pierre > Department of Pediatrics
Language :
English
Title :
Prevalence and characteristics of group B streptococcus colonization in HIV-infected pregnant women in Belgium
Publication date :
October 2017
Event name :
20th Lancefield International Symposium on Streptococci and Streptococcal Diseases 2017
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