Elucidating the functions of brain GSK3α: possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour

Pavlov, Dmitrii; Markova, Nataliia; Bettendorff, Lucien; Chekhonin, Vladimir; Pomytkin, Igor; Lioudyno, Victoria; Svistunov, Andrei; Ponomarev, Eugene; Lesch, Klaus-Peter; Strekalova, Tatyana

doi:10.1016/j.bbr.2017.08.018

Article (Scientific journals)

Elucidating the functions of brain GSK3α: possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour

Pavlov, Dmitrii; Markova, Nataliia; Bettendorff, Lucien et al.

2017 • In Behavioural Brain Research, 335, p. 122-127

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/213595

DOI
10.1016/j.bbr.2017.08.018

PubMed
28803855

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Keywords :

Depression; thiamine; GSK3ß

Abstract :

[en] positively correlated with floating behavior on the third test. A twoweek- long pretreatment regime with imipramine (7.5 mg/kg/day) or thiamine (200 mg/kg/day), which is known to have antidepressant properties, reduced the GSK3β over-expression and decreased floating behavior on Day 5. GSK3α mRNA levels were measured in the hippocampus and prefrontal cortex on Days 1, 2 and 5. GSK3α expression was decreased in the prefrontal cortex on Day 2 and increased on Day 5. In this model, GSK3α mRNA changes were prevented by imipramine or thiamine treatment. There was a significant correlation between the expression of the two isoforms in the prefrontal cortex on Day 2 in untreated group. These results provide the first evidence for the potential involvement of GSK3α in depressive-like behaviours and as a target of anti-depressant therapy. Furthermore, the correlations suggest some cross-talk may exist between the two GSK3 isoforms.

Research Center/Unit :

Giga-Neurosciences - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Pavlov, Dmitrii; Sechenov First Moscow State Medical University,

Markova, Nataliia; Sechenov First Moscow State Medical University,

Bettendorff, Lucien ; Université de Liège > GIGA-Neurosciences > Laboratory of Neurophysiology

Chekhonin, Vladimir

Pomytkin, Igor

Lioudyno, Victoria

Svistunov, Andrei

Ponomarev, Eugene

Lesch, Klaus-Peter

Strekalova, Tatyana; Maastricht University > Department of Neuroscience

Language :

English

Title :

Elucidating the functions of brain GSK3α: possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour

Publication date :

2017

Journal title :

Behavioural Brain Research

ISSN :

0166-4328

eISSN :

1872-7549

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

335

Pages :

122-127

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 17 August 2017

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