Article (Scientific journals)
L'utilisation du ratio sFlt-1/PlGF dans la preeclampsie : une analyse retrospective monocentrique.
Verbeurgt, Lievine; CHANTRAINE, Frédéric; DE MARCHIN, Jérôme et al.
2017In Revue Médicale de Liège, 72 (9), p. 393-398
Peer reviewed
 

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Keywords :
Angiogenic factors; Prediction; Pregnancy; sFlt; 1/PlGF ratio; Preeclampsia
Abstract :
[en] Soluble Fms-like tyrosine kinase 1 (sFlt-1) is an anti-angiogenic factor released in higher amounts in preeclampsia and implicated in endothelial dysfunction. sFlt-1/PlGF ratio is used in the prediction of preeclampsia. An sFlt-1/PlGF ratio inferior to 38 predicts the short-term absence of preeclampsia. A ratio ? 85 (early-onset PE) or ? 110 (late-onset of PE) could diagnose preeclampsia. In this study, sFlt-1/PlGF ratio has been measured in 183 patients. Sixty-seven preeclampsia have been diagnosed preeclamptic at delivery. The median sFlt-1/PlGF ratio was 100.3. The median ratio among women with preeclampsia (N=67) versus no preeclampsia (N=116) was 212.7 versus 35.4. In accordance with this analysis, an sFlt-1/PlGF ratio ? 38 has a sensibility of 95,5 % and a specificity of 73.3 %. The positive predictive value and the negative predictive value were 67.4 % and 96.6 %, respectively. These results suggest that sFlt-1/PlGF ratio is helpful in the diagnosis of preeclampsia.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Verbeurgt, Lievine ;  Université de Liège - ULiège > Master méd. (ex 4e master en 4 ans)
CHANTRAINE, Frédéric  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de gynécologie-obstétrique (CHR)
DE MARCHIN, Jérôme;  Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Biologie Clinique
MINON, Jean-Marc;  Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Biologie Clinique > Biologie Clinique
Nisolle, Michelle ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Language :
French
Title :
L'utilisation du ratio sFlt-1/PlGF dans la preeclampsie : une analyse retrospective monocentrique.
Alternative titles :
[en] Use of sFlt-1/PlGF ratio in preeclampsia : a monocentric retrospective analysis
Publication date :
2017
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
72
Issue :
9
Pages :
393-398
Peer reviewed :
Peer reviewed
Available on ORBi :
since 30 July 2017

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