Reginster JY, Burlet N. Osteoporosis: a still increasing prevalence. Bone. 2006 Feb;38(2 Suppl 1):S4–9.
Boonen S, Dejaeger E, Vanderschueren D, et al. Osteoporosis and osteoporotic fracture occurrence and prevention in the elderly: a geriatric perspective. Best Pract Res Clin Endocrinol Metab. 2008 Oct; 22(5): 765–85.
GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015; 385(9963):117–71.
Lello S, Capozzi A, Scambia G. Osteoporosis and cardiovascular disease: an update. Gynecol Endocrinol. 2015; 31(8):590–4.
Lampropoulos CE, Papaioannou I, David P, Cruz D. Osteoporosis—a risk factor for cardiovascular. Nat Rev Rheumatol. 2012; 8(10):587–98.
Adragao T, Herberth J, Monier-Faugere M-C, et al. Low bone volume—a risk factor for coronary calcifications in hemodialysis patients. Clin J Am Soc Nephrol. 2009; 4(2):450–5.
Choi SH, An JH, Lim S, et al. Lower bone mineral density is associated with higher coronary calcification and coronary plaque burdens by multidetector row coronary computed tomography in pre- and postmenopausal women. Clin Endocrinol (Oxf). 2009; 71(5):644–51.
Hyder JA, Allison MA, Barrett-Connor E, et al. Bone mineral density and atherosclerosis: The Multi-Ethnic Study of Atherosclerosis, Abdominal Aortic Calcium Study. Atherosclerosis. 2010; 209(1):283–9.
Fusaro M, Crepaldi G, Maggi S, et al. Vitamin K, bone fractures, and vascular calcifications in chronic kidney disease: an important but poorly studied relationship. J Endocrinol Invest. 2011; 34:317–23.
Giachelli CM. Vascular calcification mechanisms. J Am Soc Nephrol. 2004; 15(12):2959–64.
Dalmeijer GW, Van Der Schouw YT, Magdeleyns EJ, et al. Matrix gla protein species and risk of cardiovascular events in type 2 diabetic patients. Diabetes Care. 2013; 36(11):3766–71.
Boyce BF, Xing L. The RANKL/RANK/OPG pathway. Curr Osteoporos Rep. 2007; 5(3):98–104.
Wang L, Song Y, Manson JE, et al. Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies. Circulation. 2012; 5(6):819–29.
van Ballegooijen AJ, Reinders I, Visser M, Brouwer IA. Parathyroid hormone and cardiovascular disease events: a systematic review and meta-analysis of prospective studies. Am Heart J. 2013 May; 165(5):655–64, 664–5.
Qu X, Huang X, Jin F, et al. Bone mineral density and all-cause, cardiovascular and stroke mortality: a meta-analysis of prospective cohort studies. Int J Cardiol. 2013; 166(2):385–93.
Fisher A, Srikusalanukul W, Davis M, Smith P. Cardiovascular diseases in older patients with osteoporotic hip fracture: prevalence, disturbances in mineral and bone metabolism, and bidirectional links. Clin Interv Aging. 2013; 8:239–56.
Sennerby U, Melhus H, Gedeborg R, et al. Cardiovascular diseases and risk of hip fracture. JAMA. 2009 Oct 21; 302(15):1666–73.
von Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008; 61(4):344–9.
Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009; 6(7):e1000100.
Ottawa Hospital Research Institute. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. Wells G, Shea B, O'Connell D, et al. [Internet]. Ottawa, ON (Canada): Ottawa Hospital Research Institute; 2014 [cited 2017 Feb 7]. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177–88.
Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539–58.
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315(September):629–34.
Browner WS, Seeley DG, Vogt TM, Cummings SR. Non-trauma mortality in elderly women with low bone mineral density. Study of Osteoporotic Fractures Research Group. Lancet. 1991; 338(8763):355–8.
Buckens CF, de Jong PA, Verkooijen HM, Verhaar HJ, Mali WP, van der Graaf Y. Vertebral fractures on routine chest computed tomography: relation with arterial calcifications and future cardiovascular events. Int J Cardiovasc Imaging. 2015; 31(2):437–45.
Cameron ID, Chen JS, March LM, et al. Hip fracture causes excess mortality due to cardiovascular and infectious disease in institutionalized older people: a prospective five-year study. J Bone Miner Res. 2010; 25:866–72.
Chen SJ, Lin CS, Lin CL, Kao CH. Osteoporosis Is Associated With High Risk for Coronary Heart Disease: A Population-Based Cohort Study. Medicine (Baltimore). 2015; 94(27):e1146.
Chen YC, Wu JC, Liu L, et al. Hospitalized osteoporotic vertebral fracture increases the risk of stroke: a population-based cohort study. J Bone Miner Res. 2013; 28(3):516–23.
Chiang CH, Liu CJ, Chen PJ, et al. Hip fracture and risk of acute myocardial infarction: a nationwide study. J Bone Miner Res. 2013; 28(2):404–11.
Domiciano DS, Machado LG, Lopes JB, et al. Bone mineral density and parathyroid hormone as independent risk factors for mortality in community-dwelling older adults: a population-based prospective cohort study in Brazil. The São Paulo Ageing & Health (SPAH) Study. J Bone Miner Res. 2016; 31(6):1146–57.
Farhat GN, Newman AB, Sutton-Tyrrell K, et al. The association of bone mineral density measures with incident cardiovascular disease in older adults. Osteoporos Int. 2007; 18(7):999–1008.
Koh GCH, Tai BC, Ang LW, Heng D, Yuan JM, Koh WP. All-cause and cause-specific mortality after hip fracture among Chinese women and men: The Singapore Chinese Health Study. Osteoporos Int. 2013; 24(7):1981–9.
Kuo CH, Hsieh TC, Wang CH, et al. Increased risks of mortality and atherosclerotic complications in incident hemodialysis patients subsequently with bone fractures: a nationwide case-matched cohort study. PLoS One. 2015; 10(4):1–13.
Lin CH, Chang WC, Kuo CN, et al. A population-based five-year study on the risk of stroke in patients with osteoporosis in Taiwan. Bone. 2015; 72:9–13.
Matsubara K, Suliman ME, Qureshi AR, et al. Bone mineral density in end-stage renal disease patients: association with wasting, cardiovascular disease and mortality. Blood Purif. 2008; 26(3):284–90.
Mussolino ME, Madans JH, Gillum RF. Bone mineral density and stroke. Stroke. 2003; 34(5):E20–2.
Mussolino ME, Armenian HK. Low bone mineral density, coronary heart disease, and stroke mortality in men and women: The Third National Health and Nutrition Examination Survey. Ann Epidemiol. 2007; 17(11):841–6.
Nordström A, Eriksson M, Stegmayr B, Gustafson Y, Nordström P. Low bone mineral density is an independent risk factor for stroke and death. Cerebrovasc Dis. 2010; 29:130–6.
Pfister R, Michels G, Sharp SJ, Luben R, Wareham NJ, Khaw KT. Low bone mineral density predicts incident heart failure in men and women. The EPIC (European Prospective Investigation Into Cancer and Nutrition)-Norfolk Prospective Study. JACC Heart Fail. 2014; 2(4):380–9.
Pinheiro MM, Castro CM, Szejnfeld VL. Low femoral bone mineral density and quantitative ultrasound are risk factors for new osteoporotic fracture and total and cardiovascular mortality: a 5-year population-based study of Brazilian elderly women. J Gerontol A Biol Sci Med Sci. 2006 Feb; 61(2):196–203.
Shen C, Deng J, Zhou R, et al. Relation between bone mineral density, bone loss and the risk of cardiovascular disease in a Chinese cohort. Am J Cardiol. 2012; 110(8):1138–42.
Szulc P, Samelson EJ, Kiel DP, Delmas PD. Increased bone resorption is associated with increased risk of cardiovascular events in men: the MINOS study. J Bone Miner Res. 2009; 24(12):2023–31.
Trivedi DP, Khaw KT. Bone mineral density at the hip predicts mortality in elderly men. Osteoporos Int. 2001; 12(4):259–65.
Tsai CH, Lin CL, Hsu HC, Chung WS. Increased risk of coronary heart disease in patients with hip fracture: a nationwide cohort study. Osteoporos Int. 2015; 26(6):1849–55.
Varosy PD, Shlipak MG, Vittinghoff E, et al. Fracture and the risk of coronary events in women with heart disease. Am J Med. 2003; 115(3):196–202.
von der Recke P, Hansen MA, Hassager C. The association between low bone mass at the menopause and cardiovascular mortality. Am J Med. 1999; 106(3):273–8.
von Friesendorff M, McGuigan FE, Wizert A, et al. Hip fracture, mortality risk, and cause of death over two decades. Osteoporos Int. 2016; 27(10):2945–53.
Wiklund P, Nordström A, Jansson J-H, Weinehall L, Nordström P. Low bone mineral density is associated with increased risk for myocardial infarction in men and women. Osteoporos Int. 2012; 23(3):963–70.
Xu B, Han L, Liu H, et al. Cardiovascular disease and hip fracture among older inpatients in Beijing, Chine. Biomed Res Int. 2013; 2013:493696.
Yu TM, Lin CL, Shu KH, et al. Increased risk of cardiovascular events in end-stage renal disease patients with osteoporosis: a nationwide population-based cohort study. Osteoporos Int. 2014; 26(2):785–93.
Zhou R, Liu D, Li R, et al. Low bone mass is associated with stroke in Chinese postmenopausal women: The Chongqing Osteoporosis Study. Cell Biochem Biophys. 2015; 71(3):1695–701.
Browner WS, Pressman AR, Nevitt MC, Cauley JA, Cummings SR. Association between low bone density and stroke in elderly women. The Study of Osteoporotic Fractures. Stroke. 1993; 24(7):940–6.
Mussolino ME, Looker AC, Madans JH, Langlois JA, Orwoll ES. Risk factors for hip fracture in white men: the NHANES I Epidemiologic Follow-up Study. J Bone Miner Res. 1998 Jun; 13(6):918–24.
Liu LK, Lee WJ, Chen LY, et al. Association between frailty, osteoporosis, falls and hip fractures among community-dwelling people aged 50 years and older in Taiwan: results from I-Lan Longitudinal Aging Study. PLoS One. 2015; 10(9):e0136968.
Ilich JZ, Kelly OJ, Kim Y, Spicer MT. Low-grade chronic inflammation perpetuated by modern diet as a promoter of obesity and osteoporosis. Arh Hig Rada Toksikol. 2014 Jun; 65(2):139–48.
Danesh J, Whincup P, Walker M, et al. Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. BMJ. 2000; 321(7255):199–204.
Karwowski W, Naumnik B, Szczepański M, Myśliwiec M. The mechanism of vascular calcification—a systematic review. Med Sci Monit. 2012; 18(1):RA1–11.
Mitchell GF. Arterial stiffness and wave reflection: biomarkers of cardiovascular risk. Artery Res. 2009; 3:56–64.
O'Halloran PD, Blackstock F, Shields N, et al. Motivational interviewing to increase physical activity in people with chronic health conditions: a systematic review and meta-analysis. Clin Rehabil. 2014; 28(12):1159–71.
Dumurgier J, Elbaz A, Ducimetière P, Tavernier B, Alpérovitch A, Tzourio C. Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study. BMJ. 2009; 339:b4460.
Sergi G, Veronese N, Fontana L, et al. Pre-frailty and risk of cardiovascular disease in elderly men and women: the Pro.V.A. study. J Am Coll Cardiol. 2015 Mar 17; 65(10):976–83.
Cheng SJ, Yu HK, Chen YC, et al. Physical activity and risk of cardiovascular disease among older adults. Int J Gerontol. 2013; 7(3):133–6.
Shiroma EJ, Lee IM. Physical activity and cardiovascular health. Circulation. 2010 Aug 17; 122(7):743–52.
Rong K, Liu X, Wu X, et al. Increasing level of leisure physical activity could reduce the risk of hip fracture in older women: a dose-response meta-analysis of prospective cohort studies. Medicine (Baltimore). 2016 Mar; 95(11):e2984.
Trelle S, Reichenbach S, Wandel S, et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ. 2011 Jan 11; 342:c7086.
Paccou J, D'Angelo S, Edwards M, Cooper C, Petersen S, Harvey NC. A fragility fracture increases the risk of incident cardiovascular events in men: findings from UK Biobank. Osteoporos Int. 2016; 27(1 Suppl):S59–60.
Peters SAE, Huxley RR, Woodward M. Diabetes as a risk factor for stroke in women compared with men: a systematic review and meta-analysis of 64 cohorts, including 775,385 individuals and 12,539 strokes. Lancet. 2014 Jun 7; 383(9933):1973–80.
Krämer HU, Raum E, Rüter G, et al. Gender disparities in diabetes and coronary heart disease medication among patients with type 2 diabetes: results from the DIANA study. Cardiovasc Diabetol. 2012 Jan; 11:88.
Stubbs B, Brefka S, Denkinger MD. What works to prevent falls in community-dwelling older adults? Umbrella review of meta-analyses of randomized controlled trials. Phys Ther. 2015 Aug; 95(8):1095–110.
Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000 Apr 19; 283(15):2008–12.
Kim DH, Rogers JR, Fulchino LA, Kim CA, Solomon DH, Kim SC. Bisphosphonates and risk of cardiovascular events: a meta-analysis. PLoS One. 2015 Apr 17; 10(4):e0122646.