Serum Creatinine: Not So Simple!

[en] Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological limitations of serum creatinine due notably to its tubular secretion and the influence of muscular mass or protein intake on its concentration. We mainly focus on the analytical limitations of serum creatinine, insisting on important concept such as reference intervals, standardization (and IDMS traceability), analytical interferences, analytical coefficient of variation (CV), biological CV and critical difference. Because the relationship between serum creatinine and glomerular filtration rate is hyperbolic, all these CVs will impact not only the precision of serum creatinine but still more the precision of different creatinine-based equations, especially in low or normal-low creatinine levels (or high or normal-high glomerular filtration rate range).

Disciplines :

Urology & nephrology
Laboratory medicine & medical technology

Author, co-author :

DELANAYE, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Service de néphrologie

Cavalier, Etienne ; Université de Liège > Département de pharmacie > Chimie médicale

Pottel, Hans

Language :

English

Title :

Serum Creatinine: Not So Simple!

Publication date :

2017

Journal title :

Nephron journals

ISSN :

1660-8151

eISSN :

2235-3186

Publisher :

Karger, Basel, Switzerland

Volume :

136

Issue :

Pages :

302-308

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 04 July 2017

Statistics

Number of views

340 (6 by ULiège)

Number of downloads

355 (5 by ULiège)

More statistics

Scopus citations^®

235

Scopus citations^®
without self-citations

219

OpenCitations

149

OpenAlex citations

286

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