Reference : Transcriptome wide analysis of natural antisense transcripts shows potential role in ...
Scientific congresses and symposiums : Poster
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/212460
Transcriptome wide analysis of natural antisense transcripts shows potential role in breast cancer
English
Wenric, Stéphane mailto [Université de Liège > Département des sciences cliniques > Oncologie >]
El Guendi, Sonia mailto []
CABERG, Jean-Hubert mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de génétique >]
Bezzaou, Warda []
Fasquelle, Corinne mailto [Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine >]
Charloteaux, Benoît mailto [Université de Liège > > GIGA-Research >]
Karim, Latifa mailto [Université de Liège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Hennuy, Benoit []
FRERES, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service d'oncologie médicale >]
COLLIGNON, Joëlle mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service d'oncologie médicale >]
BOUKERROUCHA, Meriem mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service d'oncologie médicale >]
SCHROEDER, Hélène mailto [Centre Hospitalier Universitaire de Liège - CHU > > Centre d'oncologie >]
Olivier, Fabrice mailto [Université de Liège > > GIGA-R : Services généraux de l'Université >]
Jossa, Véronique []
JERUSALEM, Guy mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service d'oncologie médicale >]
JOSSE, Claire mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service d'oncologie médicale >]
BOURS, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de génétique >]
May-2017
A1
Yes
No
International
50th meeting of the European Society of Human Genetics
from 27-05-2017 to 30-05-2017
European Society of Human Genetics
Copenhagen
Denmark
[en] transcriptome ; breast cancer ; antisense ; lncRNA ; non coding ; long non coding rna ; rna-seq ; cancer
[en] Non-coding RNAs (ncRNA) represent at least 1/5 of the mammalian transcript amount, and about 90% of the genome length is actively transcribed. Many ncRNAs have been demonstrated to play a role in cancer. Among them, natural antisense transcripts (NAT) are RNA sequences which are complementary and overlapping to those of protein-coding transcripts (PCT). NATs were punctually described as regulating gene expression, and are expected to act more frequently in cis than other ncRNAs that commonly function in trans. In this work, 22 breast cancers expressing estrogen receptors and their paired healthy tissues were analyzed by strand-specific RNA sequencing. To highlight the potential role of NATs in gene regulations occurring in breast cancer, three different gene extraction methods were used: differential expression analysis of NATs between tumor and healthy tissues, differential correlation analysis of paired NAT/PCT between tumor and healthy tissues, and NAT/PCT read count ratio variation between tumor and healthy tissues. Each of these methods yielded lists of NAT/PCT pairs that were demonstrated to be enriched in survival-associated genes on an independent cohort (TCGA). This work allows to highlight NAT lists that display a strong potential to affect the expression of genes involved in the breast cancer pathology.
GIGA‐Research - GIGA‐R
Communauté française de Belgique - CfB ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/212460

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