Brain Mapping/methods; Cooperative Behavior; Genome-Wide Association Study/methods; Humans; Meta-Analysis as Topic; Neuroimaging/methods
Abstract :
[en] The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
Disciplines :
Genetics & genetic processes
Author, co-author :
Thompson, Paul M.
Stein, Jason L.
Medland, Sarah E.
Hibar, Derrek P.
Vasquez, Alejandro Arias
Renteria, Miguel E.
Toro, Roberto
Jahanshad, Neda
Schumann, Gunter
Franke, Barbara
Wright, Margaret J.
Grimm, Oliver
Gruber, Oliver
Guadalupe, Tulio
Gur, Raquel E.
Gur, Ruben C.
Goring, Harald H. H.
Hagenaars, Saskia
Hajek, Tomas
Hall, Geoffrey B.
Hall, Jeremy
Martin, Nicholas G.
Hardy, John
Hartman, Catharina A.
Hass, Johanna
Hatton, Sean N.
Haukvik, Unn K.
Hegenscheid, Katrin
Heinz, Andreas
Hickie, Ian B.
Ho, Beng-Choon
Hoehn, David
Agartz, Ingrid
Hoekstra, Pieter J.
Hollinshead, Marisa
Holmes, Avram J.
Homuth, Georg
Hoogman, Martine
Hong, L. Elliot
Hosten, Norbert
Hottenga, Jouke-Jan
Hulshoff Pol, Hilleke E.
Hwang, Kristy S.
Alda, Martin
Jack, Clifford R. Jr
Jenkinson, Mark
Johnston, Caroline
Jonsson, Erik G.
Kahn, Rene S.
Kasperaviciute, Dalia
Kelly, Sinead
Kim, Sungeun
Kochunov, Peter
Koenders, Laura
Alhusaini, Saud
Kramer, Bernd
Kwok, John B. J.
Lagopoulos, Jim
Laje, Gonzalo
Landen, Mikael
Landman, Bennett A.
Lauriello, John
Lawrie, Stephen M.
Lee, Phil H.
Le Hellard, Stephanie
Almasy, Laura
Lemaitre, Herve
Leonardo, Cassandra D.
Li, Chiang-Shan
Liberg, Benny
Liewald, David C.
Liu, Xinmin
Lopez, Lorna M.
Loth, Eva
Lourdusamy, Anbarasu
Luciano, Michelle
Almeida, Jorge
Macciardi, Fabio
Machielsen, Marise W. J.
Macqueen, Glenda M.
Malt, Ulrik F.
Mandl, Rene
Manoach, Dara S.
Martinot, Jean-Luc
Matarin, Mar
Mather, Karen A.
Mattheisen, Manuel
Alpert, Kathryn
Mattingsdal, Morten
Meyer-Lindenberg, Andreas
McDonald, Colm
McIntosh, Andrew M.
McMahon, Francis J.
McMahon, Katie L.
Meisenzahl, Eva
Melle, Ingrid
Milaneschi, Yuri
Mohnke, Sebastian
Andreasen, Nancy C.
Montgomery, Grant W.
Morris, Derek W.
Moses, Eric K.
Mueller, Bryon A.
Munoz Maniega, Susana
Muhleisen, Thomas W.
Muller-Myhsok, Bertram
Mwangi, Benson
Nauck, Matthias
Nho, Kwangsik
Andreassen, Ole A.
Nichols, Thomas E.
Nilsson, Lars-Goran
Nugent, Allison C.
Nyberg, Lars
Olvera, Rene L.
Oosterlaan, Jaap
Ophoff, Roel A.
Pandolfo, Massimo
Papalampropoulou-Tsiridou, Melina
Papmeyer, Martina
Apostolova, Liana G.
Paus, Tomas
Pausova, Zdenka
Pearlson, Godfrey D.
Penninx, Brenda W.
Peterson, Charles P.
Pfennig, Andrea; Université de Liège > Department of Chemical Engineering > PEPs - Products, Environment, and Processes
Phillips, Mary
Pike, G. Bruce
Poline, Jean-Baptiste
Potkin, Steven G.
Appel, Katja
Putz, Benno
Ramasamy, Adaikalavan
Rasmussen, Jerod
Rietschel, Marcella
Rijpkema, Mark
Risacher, Shannon L.
Roffman, Joshua L.
Roiz-Santianez, Roberto
Romanczuk-Seiferth, Nina
Rose, Emma J.
Armstrong, Nicola J.
Royle, Natalie A.
Rujescu, Dan
Ryten, Mina
Sachdev, Perminder S.
Salami, Alireza
Satterthwaite, Theodore D.
Savitz, Jonathan
Saykin, Andrew J.
Scanlon, Cathy
Schmaal, Lianne
Aribisala, Benjamin
Schnack, Hugo G.
Schork, Andrew J.
Schulz, S. Charles
Schur, Remmelt
Seidman, Larry
Shen, Li
Shoemaker, Jody M.
Simmons, Andrew
Sisodiya, Sanjay M.
Smith, Colin
Bastin, Mark E.
Smoller, Jordan W.
Soares, Jair C.
Sponheim, Scott R.
Sprooten, Emma
Starr, John M.
Steen, Vidar M.
Strakowski, Stephen
Strike, Lachlan
Sussmann, Jessika
Samann, Philipp G.
Bauer, Michael
Teumer, Alexander
Toga, Arthur W.
Tordesillas-Gutierrez, Diana
Trabzuni, Daniah
Trost, Sarah
Turner, Jessica
Van den Heuvel, Martijn
van der Wee, Nic J.
van Eijk, Kristel
van Erp, Theo G. M.
Bearden, Carrie E.
van Haren, Neeltje E. M.
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Valdes Hernandez, Maria C.
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Whalley, Heather C.
Whelan, Christopher D.
White, Tonya
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