Article (Scientific journals)
Presynaptic control of efficacy of GABAergic synapses in the hippocampus
Axmacher, Nikolai; Stemmler, Martin; Engel, Dominique et al.
2001In Neurocomputing, 38-40, p. 99-104
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Keywords :
synaptic plasticity; metabolism; Readily releasable pool
Abstract :
[en] First we found that applying substances that change intracellular presynaptic GABA concentration alter the synaptic e$cacy of hippocampal GABAergic neurons. The amplitude as well as the frequency of occurrence of spontaneous postsynaptic currents (mIPSCs) are a!ected. Then, we developed a model of presynaptic vesicle dynamics to better understand the causal relationship between cytosolic GABA concentration and mIPSC amplitude and frequency. One way to explain our experimental "ndings is to postulate that the "lling of vesicles as well as their transition into the readily releasable pool depends on vesicular GABA content
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Axmacher, Nikolai
Stemmler, Martin
Engel, Dominique  ;  Université de Liège > Département des sciences biomédicales et précliniques > Pharmacologie
Draguhn, Andreas
Ritz, Raphael
Language :
English
Title :
Presynaptic control of efficacy of GABAergic synapses in the hippocampus
Publication date :
2001
Journal title :
Neurocomputing
ISSN :
0925-2312
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
38-40
Pages :
99-104
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
AvH - Alexander von Humboldt Foundation [DE]
DFG - Deutsche Forschungsgemeinschaft [DE]
HFPS - International Human Frontier Science Program Organization [FR]
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