Abstract :
[en] First we found that applying substances that change intracellular presynaptic GABA concentration
alter the synaptic e$cacy of hippocampal GABAergic neurons. The amplitude as well as
the frequency of occurrence of spontaneous postsynaptic currents (mIPSCs) are a!ected. Then,
we developed a model of presynaptic vesicle dynamics to better understand the causal relationship
between cytosolic GABA concentration and mIPSC amplitude and frequency. One way to
explain our experimental "ndings is to postulate that the "lling of vesicles as well as their
transition into the readily releasable pool depends on vesicular GABA content
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