Reference : OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential...
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
http://hdl.handle.net/2268/211299
OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages
English
QUESADA-CALVO, Florence [Université de Liège > GIGA-R > Translationnal gastroenterology > >]
MASSOT, Charlotte mailto [Centre Hospitalier Universitaire de Liège - CHU > GIGA-R > Hépato-gastroentérologie et oncologie digestive -gastroentérologie translationnelle > >]
Bertrand, Virginie mailto [Université de Liège > Département de chimie (sciences) > Département de chimie (sciences) >]
Longuespée, Rémi [Université de Liège > Département de chimie (sciences) > Center for Analytical Research and Technology (CART) >]
BLETARD, Noëlla [Centre Hospitalier Universitaire de Liège - CHU > > Service d'anatomie et cytologie pathologiques >]
SOMJA, Joan mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service dermatopathologie >]
Mazzucchelli, Gabriel mailto [Université de Liège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.) >]
Smargiasso, Nicolas mailto [Université de Liège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.) >]
Baiwir, Dominique mailto [Université de Liège > > GIGA-Technology platforms : Plate-forme protéomique >]
De Pauw-Gillet, Marie-Claire mailto [Université de Liège > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Delvenne, Philippe mailto [Université de Liège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
MALAISE, Michel mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie >]
COIMBRA MARQUES, Carla mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdo, sénologique, endocrine et de transplantation >]
POLUS, Marc [Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive >]
De Pauw, Edwin mailto [Université de Liège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.) >]
MEUWIS, Marie-Alice mailto [Centre Hospitalier Universitaire de Liège - CHU > GIGA-R > Service d'hépato-gastroentérologie et oncologie digestive/ Gastroenterologie Translationnelle > >]
Louis, Edouard mailto [Université de Liège > Département des sciences cliniques > Hépato-gastroentérologie >]
24-Mar-2017
Clinical Proteomics
Springer Science & Business Media B.V.
24
9
Yes (verified by ORBi)
International
1542-6416
[en] Proteomics ; colorectal cancer ; biomarkers
[en] Abstract
Background: Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the
identification of patients with preneoplastic lesions or with early CRC stages remains challenging and is important for
reducing CRC incidence and increasing patient’s survival.
Methods: We analysed 76 colorectal tissue samples originated from early CRC stages, normal or inflamed mucosa by
label-free proteomics. The characterisation of three selected biomarker candidates was performed by immunohisto‑
chemistry on an independent set of precancerous and cancerous lesions harbouring increasing CRC stages.
Results: Out of 5258 proteins identified, we obtained 561 proteins with a significant differential distribution among
groups of patients and controls. KNG1, OLFM4 and Sec24C distributions were validated in tissues and showed differ‑
ent expression levels especially in the two early CRC stages compared to normal and preneoplastic tissues.
Conclusion: We highlighted three proteins that require further investigations to better characterise their role in early
CRC carcinogenesis and their potential as early CRC markers.
Giga-Infection, Immunity and Inflammation
plan cancer, Télévie-FRNS, CAC, SRBG
Researchers ; Professionals
http://hdl.handle.net/2268/211299
10.1186/s12014-017-9143-3
https://clinicalproteomicsjournal.biomedcentral.com/articles/10.1186/s12014-017-9143-3

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