Reference : The Unexpected Roles of Aurora A Kinase in Gliobastoma Recurrences
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/210560
The Unexpected Roles of Aurora A Kinase in Gliobastoma Recurrences
English
Willems, Estelle mailto [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (paysage)]
LOMBARD, Arnaud [Centre Hospitalier Universitaire de Liège - CHU > > Service de neurochirurgie >]
Dedobbeleer, Matthias mailto [Université de Liège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Goffart, Nicolas []
Rogister, Bernard mailto [Université de Liège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
29-Aug-2016
Targeted oncology
Springer
12
11-18
Yes
International
1776-2596
1776-260X
Switzerland
[en] Glioblastoma ; Aurora A ; Glioblastoma initiating cells
[en] The main obstacle for the cure of glioblastoma (GBM) is systematic tumor recurrence after treatment. More than 90 % of GBM tumors are indeed recurrent within 5 years after diagnosis and treatment. We urgently need new therapies to specifically address these deadly relapses. A major advance in the understanding of GBM recurrence is the identification of GBMInitiating Cells (GIC), characterized by their abilities for self-renewal, multilineage differentiation, and proliferation. It appears that these features of GIC could be modulated by the mitotic kinase Aurora A (AurA). Indeed, besides its role in mitosis, AurA has recently been identified to regulate alternative functions like cell polarity, asymmetric cell division, and epithelial to mesenchymal transition. All these properties may help explain GBM therapeutic resistance and recurrence. In this review, we make the hypothesis that AurA could
significantly contribute to GBM recurrences and we focus on the possible roles of AurA in GIC.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq
Implication of AurA kinase in GBM cells chemotaxis in response to the production of CXCL12 in the subventricular zones
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/210560
10.1007/s11523-016-0457-2
https://link.springer.com/article/10.1007%2Fs11523-016-0457-2
February 2017, Volume 12, Issue 1, pp 11–18

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