Article (Scientific journals)
The unexpected role of Aurora A kinase in glioblastoma recurrences
Willems, Estelle; LOMBARD, Arnaud; Dedobbeleer, Matthias et al.
2017In Targeted Oncology, 12, p. 11-18
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Keywords :
Glioblastoma; Aurora A; Glioblastoma initiating cells
Abstract :
[en] The main obstacle for the cure of glioblastoma (GBM) is systematic tumor recurrence after treatment. More than 90 % of GBM tumors are indeed recurrent within 5 years after diagnosis and treatment. We urgently need new therapies to specifically address these deadly relapses. A major advance in the understanding of GBM recurrence is the identification of GBMInitiating Cells (GIC), characterized by their abilities for self-renewal, multilineage differentiation, and proliferation. It appears that these features of GIC could be modulated by the mitotic kinase Aurora A (AurA). Indeed, besides its role in mitosis, AurA has recently been identified to regulate alternative functions like cell polarity, asymmetric cell division, and epithelial to mesenchymal transition. All these properties may help explain GBM therapeutic resistance and recurrence. In this review, we make the hypothesis that AurA could significantly contribute to GBM recurrences and we focus on the possible roles of AurA in GIC.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Oncology
Author, co-author :
Willems, Estelle ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (paysage)
LOMBARD, Arnaud  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de neurochirurgie
Dedobbeleer, Matthias ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Goffart, Nicolas
ROGISTER, Bernard  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie
Language :
English
Title :
The unexpected role of Aurora A kinase in glioblastoma recurrences
Publication date :
2017
Journal title :
Targeted Oncology
ISSN :
1776-2596
eISSN :
1776-260X
Publisher :
Springer, Germany
Volume :
12
Pages :
11-18
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Implication of AurA kinase in GBM cells chemotaxis in response to the production of CXCL12 in the subventricular zones
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fonds Léon Fredericq [BE]
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