Unpublished conference/Abstract (Scientific congresses and symposiums)
Activational and organizational disruption of folliculogenesis and estrous cycle caused by exposure to Bisphenol A (BPA) during early postnatal or adult life
Lopez Rodriguez, David; Franssen, Delphine; GERARD, Arlette et al.
2017Copenhague Workshop on Endocrine Disruptors (COW 2017)
 

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Keywords :
Neuroendocrinology; Endocrine Disruptors; EDC
Abstract :
[en] Our previous studies have shown that an early postnatal exposure to a very low dose of bisphenol A (BPA) disrupts sexual maturation and pubertal timing. However, the long-term effects of such low dose exposure as well as the effects of adult exposure have not been studied. One day-old and 90 day-old female rats received daily subcutaneous injections of corn oil (vehicle) or BPA (25ng/kg/d or 5mg/kg/d) for 15 days. The early postnatal exposure to both BPA doses significantly decreased the percentage of females with a regular cycle (BPA-25ng: 51±15%; BPA-5mg: 7±7%; OIL: 86±2%). The estrus cycle alterations were characterized by a decrease in time spent in proestrus (BPA-25ng: 13±3%; BPA-5mg: 12±3%; OIL: 18±3%). During adult exposure, both doses caused a disruption of the estrous cycle characterized by a significant decrease in the average time spent in proestrus (BPA-25ng: 19±2%; BPA-5mg: 17±1%; OIL: 23±1%). This effect was transient as the exposed females showed a regular cycle one month after the last dose of BPA. After adult exposure, we also observed a disruption of folliculogenesis characterized by a significant decrease of antral follicles (BPA-25ng: 21±2%; BPA-5mg: 21±2%; OIL: 36±2%) and increase of atretic follicles (BPA-25ng: 24±4%; BPA-5mg: 26±6%; OIL: 15±1%). GnRH secretion measured ex vivo 24h after adult exposure was moderately affected by BPA. Indeed, GnRH interpulse interval was significantly different when comparing animals exposed to the high or low dose of BPA but not when comparingexposed animals to the control group (BPA-25ng: 42.6±0.5; BPA-5mg: 40.2±0.6%; OIL: 41.1±0,2minutes±SEM). In conclusion, while exposure to BPA produces persistent alterations of the estrous cycle after early postnatal exposure, exposure during adulthood appears to cause activational non-persistent alternations of both the estrous cycle and folliculogenesis.
Research center :
Neuroendocrinology Unit, GIGA-neuroscience
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Lopez Rodriguez, David ;  Université de Liège > Département des sciences cliniques > Pédiatrie
Franssen, Delphine ;  Université de Liège > R&D Direction : Chercheurs ULiège en mobilité
GERARD, Arlette ;  Centre Hospitalier Universitaire de Liège - CHU > Service de pédiatrie
BALSAT, Cédric ;  Centre Hospitalier Universitaire de Liège - CHU > Centre d'oncologie
Blacher, Silvia ;  Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Noël, Agnès ;  Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Bourguignon, Jean-Pierre ;  Université de Liège > Département des sciences cliniques > Département des sciences cliniques
Parent, Anne-Simone ;  Université de Liège > Département des sciences cliniques > Pédiatrie
Language :
English
Title :
Activational and organizational disruption of folliculogenesis and estrous cycle caused by exposure to Bisphenol A (BPA) during early postnatal or adult life
Publication date :
05 May 2017
Event name :
Copenhague Workshop on Endocrine Disruptors (COW 2017)
Event place :
Copenhague, Denmark
Event date :
du 2/5/2017 au 5/5/2017
Audience :
International
Funders :
ULiège - Université de Liège [BE]
Available on ORBi :
since 14 May 2017

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