Novel genetic loci associated with hippocampal volume.

[en] The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology
Genetics & genetic processes

Author, co-author :

Hibar, Derrek P.

Adams, Hieab H. H.

Jahanshad, Neda

Chauhan, Ganesh

Stein, Jason L.

Hofer, Edith

Renteria, Miguel E.

Bis, Joshua C.

Arias-Vasquez, Alejandro

Ikram, M. Kamran

More authors (322 more)

Language :

English

Title :

Novel genetic loci associated with hippocampal volume.

Publication date :

2017

Journal title :

Nature Communications

eISSN :

2041-1723

Publisher :

Nature Publishing Group, United Kingdom

Volume :

Pages :

13624

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 May 2017

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111 (4 by ULiège)

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Scopus citations^®

200

Scopus citations^®
without self-citations

107

OpenCitations

226

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