Article (Scientific journals)
The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects.
Kochunov, Peter; Thompson, Paul M.; Winkler, Anderson et al.
2016In NeuroImage, 125, p. 189-97
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Keywords :
Adolescent; Adult; Aged; Amish/genetics; Anisotropy; Brain/physiology; Brain Mapping; Cognition/physiology; Diffusion Tensor Imaging; Female; Genotype; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; Phenotype; Registries; White Matter/physiology; Young Adult
Abstract :
[en] Speed with which brain performs information processing influences overall cognition and is dependent on the white matter fibers. To understand genetic influences on processing speed and white matter FA, we assessed processing speed and diffusion imaging fractional anisotropy (FA) in related individuals from two populations. Discovery analyses were performed in 146 individuals from large Old Order Amish (OOA) families and findings were replicated in 485 twins and siblings of the Human Connectome Project (HCP). The heritability of processing speed was h(2)=43% and 49% (both p<0.005), while the heritability of whole brain FA was h(2)=87% and 88% (both p<0.001), in the OOA and HCP, respectively. Whole brain FA was significantly correlated with processing speed in the two cohorts. Quantitative genetic analysis demonstrated a significant degree to which common genes influenced joint variation in FA and brain processing speed. These estimates suggested common sets of genes influencing variation in both phenotypes, consistent with the idea that common genetic variations contributing to white matter may also support their associated cognitive behavior.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Genetics & genetic processes
Author, co-author :
Kochunov, Peter
Thompson, Paul M.
Winkler, Anderson ;  Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.
Morrissey, Mary
Fu, Mao
Coyle, Thomas R.
Du, Xiaoming
Muellerklein, Florian
Savransky, Anya
Gaudiot, Christopher
Sampath, Hemalatha
Eskandar, George
Jahanshad, Neda
Patel, Binish
Rowland, Laura
Nichols, Thomas E.
O'Connell, Jeffrey R.
Shuldiner, Alan R.
Mitchell, Braxton D.
Hong, L. Elliot
More authors (10 more) Less
Language :
English
Title :
The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects.
Publication date :
2016
Journal title :
NeuroImage
ISSN :
1053-8119
eISSN :
1095-9572
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
125
Pages :
189-97
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2015 Elsevier Inc. All rights reserved.
Available on ORBi :
since 04 May 2017

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