Article (Scientific journals)
Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia.
Kochunov, Peter; Ganjgahi, Habib; Winkler, Anderson et al.
2016In Human Brain Mapping, 37 (12), p. 4673-4688
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Keywords :
DTI; aging; schizophrenia
Abstract :
[en] BACKGROUND: Altered brain connectivity is implicated in the development and clinical burden of schizophrenia. Relative to matched controls, schizophrenia patients show (1) a global and regional reduction in the integrity of the brain's white matter (WM), assessed using diffusion tensor imaging (DTI) fractional anisotropy (FA), and (2) accelerated age-related decline in FA values. In the largest mega-analysis to date, we tested if differences in the trajectories of WM tract development influenced patient-control differences in FA. We also assessed if specific tracts showed exacerbated decline with aging. METHODS: Three cohorts of schizophrenia patients (total n = 177) and controls (total n = 249; age = 18-61 years) were ascertained with three 3T Siemens MRI scanners. Whole-brain and regional FA values were extracted using ENIGMA-DTI protocols. Statistics were evaluated using mega- and meta-analyses to detect effects of diagnosis and age-by-diagnosis interactions. RESULTS: In mega-analysis of whole-brain averaged FA, schizophrenia patients had lower FA (P = 10-11 ) and faster age-related decline in FA (P = 0.02) compared with controls. Tract-specific heterochronicity measures, that is, abnormal rates of adolescent maturation and aging explained approximately 50% of the regional variance effects of diagnosis and age-by-diagnosis interaction in patients. Interactive, three-dimensional visualization of the results is available at www.enigma-viewer.org. CONCLUSION: WM tracts that mature later in life appeared more sensitive to the pathophysiology of schizophrenia and were more susceptible to faster age-related decline in FA values. Hum Brain Mapp 37:4673-4688, 2016. (c) 2016 Wiley Periodicals, Inc.
Disciplines :
Psychiatry
Author, co-author :
Kochunov, Peter
Ganjgahi, Habib
Winkler, Anderson ;  Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.
Kelly, Sinead
Shukla, Dinesh K.
Du, Xiaoming
Jahanshad, Neda
Rowland, Laura
Sampath, Hemalatha
Patel, Binish
O'Donnell, Patricio
Xie, Zhiyong
Paciga, Sara A.
Schubert, Christian R.
Chen, Jian
Zhang, Guohao
Thompson, Paul M.
Nichols, Thomas E.
Hong, L. Elliot
More authors (9 more) Less
Language :
English
Title :
Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia.
Publication date :
2016
Journal title :
Human Brain Mapping
ISSN :
1065-9471
eISSN :
1097-0193
Publisher :
John Wiley & Sons, Hoboken, United States - New York
Volume :
37
Issue :
12
Pages :
4673-4688
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2016 Wiley Periodicals, Inc.
Available on ORBi :
since 04 May 2017

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