Article (Scientific journals)
Influence of age, sex and genetic factors on the human brain.
McKay, D. Reese; Knowles, Emma E. M.; Winkler, Anderson et al.
2014In Brain Imaging and Behavior, 8 (2), p. 143-52
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Keywords :
Adult; Aged; Aged, 80 and over; Aging/pathology; Anisotropy; Brain/anatomy & histology; Family; Female; Gray Matter/pathology; Hispanic Americans; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways/pathology; Organ Size; Phenotype; Sex Characteristics; White Matter/pathology; Young Adult
Abstract :
[en] We report effects of age, age(2), sex and additive genetic factors on variability in gray matter thickness, surface area and white matter integrity in 1,010 subjects from the Genetics of Brain Structure and Function Study. Age was more strongly associated with gray matter thickness and fractional anisotropy of water diffusion in white matter tracts, while sex was more strongly associated with gray matter surface area. Widespread heritability of neuroanatomic traits was observed, suggesting that brain structure is under strong genetic control. Furthermore, our findings indicate that neuroimaging-based measurements of cerebral variability are sensitive to genetic mediation. Fundamental studies of genetic influence on the brain will help inform gene discovery initiatives in both clinical and normative samples.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
McKay, D. Reese
Knowles, Emma E. M.
Winkler, Anderson ;  Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.
Sprooten, Emma
Kochunov, Peter
Olvera, Rene L.
Curran, Joanne E.
Kent, Jack W. Jr
Carless, Melanie A.
Goring, Harald H. H.
Dyer, Thomas D.
Duggirala, Ravi
Almasy, Laura
Fox, Peter T.
Blangero, John
Glahn, David C.
More authors (6 more) Less
Language :
English
Title :
Influence of age, sex and genetic factors on the human brain.
Publication date :
2014
Journal title :
Brain Imaging and Behavior
ISSN :
1931-7557
eISSN :
1931-7565
Publisher :
Springer, New York, United States - New York
Volume :
8
Issue :
2
Pages :
143-52
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 May 2017

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