Unpublished conference/Abstract (Scientific congresses and symposiums)
Complementary biophysical tools to investigate lipid specificity in the interaction between bioactive peptides and the plasma membrane
Deleu, Magali; Lins, Laurence
2017PepCon- 2017-10th anniversary BIT congress
Peer reviewed
 

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Keywords :
biophysics; lipid; peptide
Abstract :
[en] Plasma membranes are complex entities common to all living cells. The basic principle of their organization appears very simple, but they are actually of high complexity and represent very dynamic structures. The interactions between bioactive molecules notably peptides, and lipids are important for numerous processes, from drug bioavailability to viral fusion. The cell membrane is a carefully balanced environment and any changes inflicted upon its structure by a bioactive peptide must be considered in conjunction with the overall effect that this may have on the function and integrity of the membrane. As a general concept, understanding the mechanism at the molecular level by which bioactive molecules interact with cell membranes is of fundamental importance. Lipid specificity is a key factor for the detailed understanding of the penetration and/or activity of lipid-interacting peptides and of mechanisms of some diseases. Further investigation in that way should improve drug discovery and development of membrane-active molecules in many domains such as health, plant protection or microbiology. In this talk, we propose to overview some complementary “in vitro” and “in silico” biophysical approaches that can give information about lipid specificity at a molecular point of view. Our strategy is illustrated on different bioactive peptides such as antimicrobial peptides, peptides involved in human diseases or in plant cell signalling.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Deleu, Magali  ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biophysique moléc. aux interfaces
Lins, Laurence  ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biophysique moléc. aux interfaces
Language :
English
Title :
Complementary biophysical tools to investigate lipid specificity in the interaction between bioactive peptides and the plasma membrane
Publication date :
March 2017
Event name :
PepCon- 2017-10th anniversary BIT congress
Event organizer :
BIT group global
Event place :
Fukuoka, Japan
Event date :
22-24/3/2017
By request :
Yes
Audience :
International
Peer reviewed :
Peer reviewed
Available on ORBi :
since 02 May 2017

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