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Modeling β-lactamase induction in Bacillus licheniformis 749/I
Dauvin, Marjorie; Vandamme, François; Abujahrur, Nora et al.
2015Bioforum
 

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Keywords :
β-lactamase; antibiotic resistance
Abstract :
[en] The intensive use of antibiotics in infectious diseases treatment has result in selection of resistance mechanisms among bacteria. The main one is the production of a β-lactamase that hydrolyzes the β-lactam ring of β-lactamines. β-lactamase could be expressed constitutively or in response to the presence of β-lactam antibiotic outside the cell. From the four β-lactamase induction mechanisms known so far, the ones from Gram positive S. aureus and B. licheniformis 749/i are very closed. Its induction system includes the divergeon blaP-blaI-blaR1 and an unrelated blaR2 gene still not identified. Recent results from our lab indicate that for the induction of β-lactamase two conditions must be fulfilled. The first one is a cellular stress due to the presence of the antibiotic outside, acylating PBP1, which triggers an increase of cell wall degradation. The second one is the acylation of the membrane receptor BlaR1 by the antibiotic, which results in the derepression of the β-lactamase gene blaP by the repressor BlaI. Amoroso et al. had showed that a fragment coming from peptidoglycan degradation interact with BlaI. In the same study, they propose that this fragment would be the result of the activity of proteins encoded by ykf operon. The aim of this project is the modeling of the β–lactamase induction mechanism in B. licheniformis 749/I.
Research center :
CIP - Centre d'Ingénierie des Protéines - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Dauvin, Marjorie ;  Université de Liège > Département des sciences de la vie > Physiologie et génétique bactériennes
Vandamme, François
Abujahrur, Nora
Amoroso, Ana Maria ;  Université de Liège > Département des sciences de la vie > Centre d'ingénierie des protéines
Joris, Bernard ;  Université de Liège > Département des sciences de la vie > Physiologie et génétique bactériennes
Language :
English
Title :
Modeling β-lactamase induction in Bacillus licheniformis 749/I
Alternative titles :
[fr] Modélisation de l'induction de la β-lactamase chez Bacillus licheniformis 749/I
Publication date :
13 May 2015
Number of pages :
A0
Event name :
Bioforum
Event organizer :
Pr. Jacques Dommes
Event place :
Liège, Belgium
Event date :
13 mai 2015
Name of the research project :
Etude de l'induction de la β-lactamase BlaP chez Bacillus licheniformis
Available on ORBi :
since 27 April 2017

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