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![]() ![]() | Gholizadeh, A., Mazzucchelli, G., Amoroso, A. M., & Gilet, T. (06 June 2025). Modular Centrifugal Microfluidics for Sample Preparation. Analytical Chemistry, 97 (23), 12070 - 12079. doi:10.1021/acs.analchem.5c00076 ![]() |
![]() ![]() | Dauvrin, T., Joris, B., Franck, F., Remacle, C., Amoroso, A. M., & Gerards, T. (02 February 2024). Chlorophyllide derivatives for use in the prevention or treatment of bacterial infection. |
![]() ![]() | Dauvrin, T., Joris, B., Franck, F., Remacle, C., Amoroso, A. M., & Gerards, T. (31 January 2024). CHLOROPHYLLIDE DERIVATIVES FOR USE IN THE PREVENTION OR TREATMENT OF BACTERIAL INFECTION. |
![]() ![]() | Wan, H., Ben Othman, R., Le Corre, L., Poinsot, M., Oliver, M., Amoroso, A. M., Joris, B., Touzé, T., Auger, R., Calvet-Vitale, S., Bosco, M., & Gravier-Pelletier, C. (02 September 2022). New MraYAA Inhibitors with an Aminoribosyl Uridine Structure and an Oxadiazole. Antibiotics, 11 (9), 1189. doi:10.3390/antibiotics11091189 ![]() |
![]() ![]() | Oliver, M., Le Corre, L., Poinsot, M., Bosco, M., Wan, H., Amoroso, A. M., Joris, B., Bouhss, A., Calvet-Vitale, S., & Gravier-Pelletier, C. (08 March 2022). A Sub-Micromolar MraYAA Inhibitor with an Aminoribosyl Uridine Structure and a (S,S)-Tartaric Diamide: Synthesis, Biological Evaluation and Molecular Modeling. Molecules, 27 (6), 1769. doi:10.3390/molecules27061769 ![]() |
![]() ![]() | Oliver, M., Le Corre, L., Poinsot, M., Corio, A., Madegard, L., Bosco, M., Amoroso, A. M., Joris, B., Auger, R., Touzé, T., Bouhss, A., Calvet-Vitale, S., & Gravier-Pelletier, C. (2021). Synthesis, biological evaluation and molecular modeling of urea-containing MraY inhibitors. Organic and Biomolecular Chemistry, 19 (26), 5844-5866. doi:10.1039/d1ob00710f ![]() |
![]() ![]() | Decuyper, L., Jukič, M., Sosič, I., Amoroso, A. M., Verlaine, O., Joris, B., Gobec, S., & D'hooghe, M. (02 January 2020). Synthesis and Penicillin-binding Protein Inhibitory Assessment of Dipeptidic 4-Phenyl-β-lactams from α-Amino Acid-derived Imines. Chemistry: An Asian Journal, 15 (1), 51-55. doi:10.1002/asia.201901470 ![]() |
![]() ![]() | Raymackers, A., Verlaine, O., Amoroso, A. M., & Joris, B. (29 November 2019). A novel model proposed to explain the mechanism leading to β-lactam resistance in Enterococcus hirae and faecium [Poster presentation]. Bioforum 2019. |
![]() ![]() | Decuyper, L., Magdalenić, K., Verstraete, M.-B., Jukič, M., Sosič, I., Sauvage, E., Amoroso, A. M., Verlaine, O., Joris, B., Gobec, S., & D'hooghe, M. (09 October 2019). α-Unsaturated 3-Amino-1-carboxymethyl-β-lactams as Bacterial PBP Inhibitors: Synthesis and Biochemical Assessment. Chemistry, 25 (70), 16128 - 16140. doi:10.1002/chem.201904139 ![]() |
![]() ![]() | Dauvin, M., Delvaux, C., Joris, B., Far, J., De Pauw, E., & Amoroso, A. M. (25 September 2019). Impact of penicillin stress on peptidoglycan peptides recycling in Bacillus spp [Poster presentation]. Great Wall Symposium. |
![]() ![]() | Raymackers, A., Maréchal, M., Verlaine, O., Amoroso, A. M., & Joris, B. (July 2019). New insights to understand enterococcal ß-lactam resistance [Poster presentation]. 20th Conference on Bacilli and Gram Positive Bacteria, Washington DC, United States. |
![]() ![]() | Mescola, A.* , Dauvin, M.* , Amoroso, A. M., Duwez, A.-S., & Joris, B. (June 2019). Single-molecule force spectroscopy to decipher the early signalling step in membrane-bound penicillin receptors embedded into a lipid bilayer. Nanoscale, 11, 12275. doi:10.1039/c9nr02466b ![]() * These authors have contributed equally to this work. |
Raymackers, A., Verlaine, O., Amoroso, A. M., & Joris, B. (07 February 2019). A new insight into β-lactam resistance in enterococci [Poster presentation]. InBioS Day. |
![]() ![]() | Raymackers, A., Verlaine, O., Amoroso, A. M., & Joris, B. (2019). Understanfing PBP5 regulation and beta-lactam resistance mechanism in Enterococcus hirae and faecium [Poster presentation]. Annual Symposium of the Belgian Society for Microbiology. |
![]() ![]() | Raymackers, A., Verlaine, O., Amoroso, A. M., & Joris, B. (2019). Understanding enterococcal β-lactam resistance [Poster presentation]. Interuniversity PhD Student Day. |
![]() ![]() | Decuyper, L., Deketelaere, S., Vanparys, L., Jukič, M., Sosič, I., Sauvage, E., Amoroso, A. M., Verlaine, O., Joris, B., Gobec, S., & D'hooghe, M. (12 October 2018). In Silico Design and Enantioselective Synthesis of Functionalized Monocyclic 3-Amino-1-carboxymethyl-β-lactams as Inhibitors of Penicillin-Binding Proteins of Resistant Bacteria. Chemistry, 24 (57), 15254-15266. doi:10.1002/chem.201801868 ![]() |
![]() ![]() | Raymackers, A., Amoroso, A. M., Joris, B., & Verlaine, O. (Other coll.). (17 May 2018). Uncovering actors of enterococcal β-lactam resistance [Poster presentation]. Bioforum 2018. |
![]() ![]() | Raymackers, A., Verlaine, O., Amoroso, A. M., & Joris, B. (2018). Transcriptome analysis of Enterococcus hirae to uncover β-lactam resistance mechanism [Poster presentation]. 2nd InBioS Day. |
![]() ![]() | Raymackers, A., Verlaine, O., Amoroso, A. M., & Joris, B. (07 December 2017). Uncovering Enterococcus hirae beta-lactam resistance mechanism through transcriptom analysis [Poster presentation]. IAP meeting Integrative Protein Science: from small molecules to complex biological systems, Liège, Belgium. |
![]() ![]() | Raymackers, A., Maréchal, M., Verlaine, O., Amoroso, A. M., & Joris, B. (13 June 2017). Study of the regulation of β-lactam resistance in Enterococcus hirae [Poster presentation]. 19th International Conference on Bacilli and Gram Positive Bacteria, Berlin, Germany. |
![]() ![]() | Raymackers, A., Maréchal, M., Verlaine, O., Amoroso, A. M., & Joris, B. (11 May 2017). Study of the regulation of the operon ftsW-psr-pbp5 in Enterococcus hirae [Poster presentation]. Interuniversity PhD student day. |
![]() ![]() | Di Gregorio, S., Fernandez, S., Cuirolo, A., Verlaine, O., Amoroso, A. M., Mengin-Lecreulx, D., Famiglietti, A., Joris, B., & Mollerach, M. (January 2017). Different Vancomycin-Intermediate Staphylococcus aureus Phenotypes Selected from the Same ST100-hVISA Parental Strain. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 23 (1), 44-50. doi:10.1089/mdr.2016.0160 ![]() |
![]() ![]() | Maréchal, M., Amoroso, A. M., Morlot, C., Vernet, T., Coyette, J., & Joris, B. (12 October 2016). Enterococcus hirae LcpA (Psr), a new peptidoglycan-binding protein localized at the division site. BMC Microbiology, 16 (1), 239. doi:10.1186/s12866-016-0844-y ![]() |
![]() ![]() | Sosic, I., Anderluh, M., Sova, M., Gobec, M., Mlinaric Rascan, I., Derouaux, A., Amoroso, A. M., Terrak, M., Breukink, E., & Gobec, S. (2015). Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5b01482 ![]() |
![]() ![]() | Dauvin, M., Amoroso, A. M., & Joris, B. (23 June 2015). Fate of the coactivator in the induction of BlaP β-lactamase in Bacillus licheniformis 749/I [Poster presentation]. 8th International Conference on gram-positive Microorganisms, Montecatini Terme, Italy. |
Dauvin, M., Vandamme, F., Abujahrur, N., Amoroso, A. M., & Joris, B. (13 May 2015). Modeling β-lactamase induction in Bacillus licheniformis 749/I [Poster presentation]. Bioforum, Liège, Belgium. |
![]() ![]() | Fer, M., Bouhss,, A. B., Patrão, M., Le Corre, L., Pietrancosta, N., Amoroso, A. M., Joris, B., Mengin-Lecreulx, D., Calvet-Vitale, S., & Gravier-Pelletier, C. (May 2015). 5′-Methylene-triazole-substituted-aminoribosyl uridines as MraY inhibitors: synthesis, biological evaluation and molecular modeling. Organic and Biomolecular Chemistry, 13 (26), 7193. doi:10.1039/c5ob00707k ![]() |
![]() ![]() | Terrasse, R., Amoroso, A. M., Vernet, T., & Di Guilmi, A. M. (2015). Streptococcus pneumoniae GAPDH Is Released by Cell Lysis and Interacts with Peptidoglycan. PLoS ONE, 10 (4), 0125377. doi:10.1371/journal.pone.0125377 ![]() |
![]() ![]() | Vassal-Stermann, E., Lacroix, M., Gout, E., Laffly, E., Pedersen, C. M., Martin, L., Amoroso, A. M., Schmidt, R. R., Zahringer, U., Gaboriaud, C., Di Guilmi, A.-M., & Thielens, N. M. (2014). Human L-ficolin recognizes phosphocholine moieties of pneumococcal teichoic acid. Journal of Immunology, 193 (11), 5699-708. doi:10.4049/jimmunol.1400127 ![]() |
![]() ![]() | Henry, X., Verlaine, O., Amoroso, A. M., Coyette, J., & Joris, B. (December 2013). Activity of ceftaroline against Enterococcus faecium PBP5. Antimicrobial Agents and Chemotherapy, 57 (12), 6358. doi:10.1128/AAC.00923-13 ![]() |
Dauvin, M., Amoroso, A. M., & Joris, B. (18 April 2013). Modeling β-lactamase induction in Bacillus licheniformis [Poster presentation]. Bioforum, Liège, Belgium. |
Zervosen, A., Sauvage, E., Bouillez, A., Herman, A., Amoroso, A. M., Joris, B., Charlier, P., & Luxen, A. (18 April 2012). Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C [Poster presentation]. Biomedica 2012, Liège, Belgium. |
![]() ![]() | Sosic, I., Turk, S., Sinreih, M., Trost, N., Verlaine, O., Amoroso, A. M., Zervosen, A., Luxen, A., Joris, B., & Gobec, S. (2012). Exploration of the chemical space of novel naphthalene-sulfonamide and anthranilic acid-based inhibitors of penicillin-binding Proteins. Acta Chimica Slovenica, 59 (2), 380-388. ![]() |
![]() ![]() | Zervosen, A., Bouillez, A., Herman, A., Amoroso, A. M., Joris, B., Sauvage, E., Charlier, P., & Luxen, A. (2012). Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C. Bioorganic and Medicinal Chemistry, 20 (12), 3915-24. doi:10.1016/j.bmc.2012.04.018 ![]() |
![]() ![]() | Amoroso, A. M., Boudet, J., Berzigotti, S., Duval, V., Teller, N., Mengin-Lecreulx, D., Luxen, A., Simorre, J.-P., & Joris, B. (2012). A peptidoglycan fragment triggers beta-lactam resistance in Bacillus licheniformis. PLoS Pathogens, 8 (3), 1002571. doi:10.1371/journal.ppat.1002571 ![]() |
![]() ![]() | Berzigotti, S., Benlafya, K., Sepulchre, J., Amoroso, A. M., & Joris, B. (2012). Bacillus licheniformis BlaR1 L3 loop is a Zinc metalloprotease activated by self-proteolysis. PLoS ONE, 7, 36400. doi:10.1371/journal.pone.0036400 ![]() |
![]() ![]() | Derouaux, A., Turk, S., Olrichs, N. K., Gobec, S., Breukink, E., Amoroso, A. M., Offant, J., Bostock, J., Mariner, K., Chopra, I., Vernet, T., Zervosen, A., Joris, B., Frère, J.-M., Nguyen Van, M., & Terrak, M. (2011). Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor. Biochemical Pharmacology, 81 (9), 1098-105. doi:10.1016/j.bcp.2011.02.008 ![]() |
![]() ![]() | Turk, S., Verlaine, O., Gerards, T., Zivec, M., Humljan, J., Sosic, I., Amoroso, A. M., Zervosen, A., Luxen, A., Joris, B., & Gobec, S. (2011). New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria. PLoS ONE, 6 (5), 19418. doi:10.1371/journal.pone.0019418 ![]() |
![]() ![]() | Contreras-Martel, C., Amoroso, A. M., Woon, E. C. Y., Zervosen, A., Inglis, S., Martins, A., Verlaine, O., Rydzik, A. M., Job, V., Luxen, A., Joris, B., Schofield, C. J., & Dessen, A. (2011). Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome beta-Lactam Resistance in Staphylococcus aureus (MRSA). ACS Chemical Biology. doi:10.1021/cb2001846 ![]() |
![]() ![]() | Sosic, I., Barreteau, H., Simcic, M., Sink, R., Cesar, J., Zega, A., Grdadolnik, S. G., Contreras-Martel, C., Dessen, A., Amoroso, A. M., Joris, B., Blanot, D., & Gobec, S. (2011). Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid. European Journal of Medicinal Chemistry, 46 (7), 2880-94. doi:10.1016/j.ejmech.2011.04.011 ![]() |
![]() ![]() | Kern, T., Giffard, M., Hediger, S., Amoroso, A. M., Giustini, C., Khai Bui, N., Joris, B., Vollmer, & Simorre, J.-P. (2010). Dynamics Characterization of Fully Hydrated Bacterial Cell Walls by Solid-State NMR: Evidence for Cooperative Binding of Metal Ions. Journal of the American Chemical Society, 132, 10911-10919. doi:10.1021/ja104533w ![]() |
![]() ![]() | Henry, X., Amoroso, A. M., Coyette, J., & Joris, B. (2010). Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. Antimicrobial Agents and Chemotherapy, 54, 953-955. doi:10.1128/AAC.00983-09 ![]() |
Derouaux, A., Turk, S., Offant, J., Amoroso, A. M., Breukink, E., Bostock, J., Chopra, I., Zervosen, A., Joris, B., Nguyen Van, M., Vernet, T., Gobec, S., & Terrak, M. (November 2009). Identification and characterization of novel peptidoglycan glycosyltransferase inhibitors with antibacterial activity [Poster presentation]. Exploration and exploitation of bacterial cell wall biosynthesis, Warwick, United Kingdom. |
![]() ![]() | Sauvage, E., Zervosen, A., Dive, G., Herman, R., Amoroso, A. M., Joris, B., Fonzé, E., Pratt, R., Luxen, A., Charlier, P., & Kerff, F. (2009). Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate. Journal of the American Chemical Society, 131 (42), 15262-15269. doi:10.1021/ja9051526 ![]() |
![]() ![]() | Kerff, F., Amoroso, A. M., Herman, R., Sauvage, E., Petrella, S., Filée, P., Charlier, P., Joris, B., Tabuchi, A., Nikolaidis, N., & Cosgrove, D. J. (2008). Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization. Proceedings of the National Academy of Sciences of the United States of America, 105 (44), 16876-81. doi:10.1073/pnas.0809382105 ![]() |
![]() ![]() | Boudet, J., Duval, V., Van Melckebeke, H., Blackledge, M., Amoroso, A. M., Joris, B., & Simorre, J. P. (2007). Conformational and thermodynamic changes of the repressor/DNA operator complex upon monomerization shed new light an regulation mechanisms of bacterial resistance against beta-lactam antibiotics. Nucleic Acids Research, 35 (13), 4384-4395. doi:10.1093/nar/gkm448 ![]() |
![]() ![]() | Rubinstein, G., Amoroso, A. M., Bavdaz, B., De Bunder, S., Blazquez, N., & Gutkind, G. O. (2005). Low macrolide resistance in Streptococcus pyogenes in Southern Argentina. International Journal of Antimicrobial Agents, 25 (5), 450-2. doi:10.1016/j.ijantimicag.2005.01.010 ![]() |
![]() ![]() | Duez, C., Hallut, S., Rhazi, N., Amoroso, A. M., Bouillenne, F., & Coyette, J. (July 2004). The ponA gene of Enterococcus faecalis JH2-2 codes for a low-affinity class a penicillin-binding protein. Journal of Bacteriology, 186 (13), 4412-4416. doi:10.1128/JB.186.13.4412-4416.2004 ![]() |
![]() ![]() | Martinez, S., Amoroso, A. M., Famiglietti, A., de Mier, C., Vay, C., & Gutkind, G. O. (2004). Genetic and phenotypic characterization of resistance to macrolides in Streptococcus pyogenes from Argentina. International Journal of Antimicrobial Agents, 23 (1), 95-8. doi:10.1016/j.ijantimicag.2003.05.009 ![]() |
![]() ![]() | Sapunaric, F., Franssen, C., Stefanic, P., Amoroso, A. M., Dardenne, O., & Coyette, J. (2003). Redefining the role of psr in beta-lactam resistance and cell autolysis of Enterococcus hirae. Journal of Bacteriology, 185 (20), 5925-35. doi:10.1128/JB.185.20.5925-5935.2003 ![]() |
![]() ![]() | Duez, C., Zorzi, W., Sapunaric, F., Amoroso, A. M., Thamm, I., & Coyette, J. (September 2001). The Penicillin Resistance of Enterococcus Faecalis Jh2-2r Results from an Overproduction of the Low-Affinity Penicillin-Binding Protein Pbp4 and Does Not Involve a Psr-Like Gene. Microbiology, 147 (Pt 9), 2561-9. doi:10.1099/00221287-147-9-2561 ![]() |
![]() ![]() | Amoroso, A. M., & Gutkind, G. O. (2001). Chromogenic detection of aminoglycoside phosphotransferases. Methods in Molecular Medicine, 48, 113-7. doi:10.1385/1-59259-077-2:113 ![]() |
![]() ![]() | Amoroso, A. M., Demares, D., Mollerach, M., Gutkind, G., & Coyette, J. (2001). All detectable high-molecular-mass penicillin-binding proteins are modified in a high-level beta-lactam-resistant clinical isolate of Streptococcus mitis. Antimicrobial Agents and Chemotherapy, 45 (7), 2075-81. doi:10.1128/AAC.45.7.2075-2081.2001 ![]() |
Pappa, H., Segall, A., Pizzorno, M. T., Radice, M., Amoroso, A. M., & Gutkind, G. O. (1994). Antimicrobial activity of 5,6-dihydrobenzo-[a]-carbazoles. Farmaco (Il), 49 (5), 333-6. ![]() |