Profil

Amoroso Ana Maria

Département des sciences de la vie > Centre d'Ingénierie des Protéines (CIP)

InBioS

See author's contact details
Main Referenced Co-authors
Joris, Bernard  (41)
Verlaine, Olivier  (18)
Raymackers, Alice  (10)
Gobec, Stanislav (9)
Zervosen, Astrid  (8)
Main Referenced Keywords
Humans (6); Penicillin-Binding Proteins (6); Anti-Bacterial Agents/pharmacology (5); Cell Wall/metabolism (5); Microbial Sensitivity Tests (5);
Main Referenced Unit & Research Centers
CIP - Centre d'Ingénierie des Protéines - ULiège (6)
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège (4)
Biological Sciences from Molecules to Systems - inBioS (1)
Biological Sciences from Molecules to Systems - inBioS, Mass spectrometry laboratory (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (35)
Microbiology (16)
Chemistry (5)

Publications (total 53)

The most downloaded
580 downloads
Vassal-Stermann, E., Lacroix, M., Gout, E., Laffly, E., Pedersen, C. M., Martin, L., Amoroso, A. M., Schmidt, R. R., Zahringer, U., Gaboriaud, C., Di Guilmi, A.-M., & Thielens, N. M. (2014). Human L-ficolin recognizes phosphocholine moieties of pneumococcal teichoic acid. Journal of Immunology, 193 (11), 5699-708. doi:10.4049/jimmunol.1400127 https://hdl.handle.net/2268/194070

The most cited

187 citations (OpenAlex)

Kerff, F., Amoroso, A. M., Herman, R., Sauvage, E., Petrella, S., Filée, P., Charlier, P., Joris, B., Tabuchi, A., Nikolaidis, N., & Cosgrove, D. J. (2008). Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization. Proceedings of the National Academy of Sciences of the United States of America, 105 (44), 16876-81. doi:10.1073/pnas.0809382105 https://hdl.handle.net/2268/23499

Dauvrin, T., Joris, B., Franck, F., Remacle, C., Amoroso, A. M., & Gerards, T. (02 February 2024). Chlorophyllide derivatives for use in the prevention or treatment of bacterial infection.

Dauvrin, T., Joris, B., Franck, F., Remacle, C., Amoroso, A. M., & Gerards, T. (31 January 2024). CHLOROPHYLLIDE DERIVATIVES FOR USE IN THE PREVENTION OR TREATMENT OF BACTERIAL INFECTION.

Wan, H., Ben Othman, R., Le Corre, L., Poinsot, M., Oliver, M., Amoroso, A. M., Joris, B., Touzé, T., Auger, R., Calvet-Vitale, S., Bosco, M., & Gravier-Pelletier, C. (02 September 2022). New MraYAA Inhibitors with an Aminoribosyl Uridine Structure and an Oxadiazole. Antibiotics, 11 (9), 1189. doi:10.3390/antibiotics11091189
Peer Reviewed verified by ORBi

Oliver, M., Le Corre, L., Poinsot, M., Bosco, M., Wan, H., Amoroso, A. M., Joris, B., Bouhss, A., Calvet-Vitale, S., & Gravier-Pelletier, C. (08 March 2022). A Sub-Micromolar MraYAA Inhibitor with an Aminoribosyl Uridine Structure and a (S,S)-Tartaric Diamide: Synthesis, Biological Evaluation and Molecular Modeling. Molecules, 27 (6), 1769. doi:10.3390/molecules27061769
Peer reviewed

Oliver, M., Le Corre, L., Poinsot, M., Corio, A., Madegard, L., Bosco, M., Amoroso, A. M., Joris, B., Auger, R., Touzé, T., Bouhss, A., Calvet-Vitale, S., & Gravier-Pelletier, C. (2021). Synthesis, biological evaluation and molecular modeling of urea-containing MraY inhibitors. Organic and Biomolecular Chemistry, 19 (26), 5844-5866. doi:10.1039/d1ob00710f
Peer Reviewed verified by ORBi

Decuyper, L., Jukič, M., Sosič, I., Amoroso, A. M., Verlaine, O., Joris, B., Gobec, S., & D'hooghe, M. (02 January 2020). Synthesis and Penicillin-binding Protein Inhibitory Assessment of Dipeptidic 4-Phenyl-β-lactams from α-Amino Acid-derived Imines. Chemistry: An Asian Journal, 15 (1), 51-55. doi:10.1002/asia.201901470
Peer Reviewed verified by ORBi

Raymackers, A., Verlaine, O., Amoroso, A. M., & Joris, B. (29 November 2019). A novel model proposed to explain the mechanism leading to β-lactam resistance in Enterococcus hirae and faecium [Poster presentation]. Bioforum 2019.

Decuyper, L., Magdalenić, K., Verstraete, M.-B., Jukič, M., Sosič, I., Sauvage, E., Amoroso, A. M., Verlaine, O., Joris, B., Gobec, S., & D'hooghe, M. (09 October 2019). α-Unsaturated 3-Amino-1-carboxymethyl-β-lactams as Bacterial PBP Inhibitors: Synthesis and Biochemical Assessment. Chemistry, 25 (70), 16128 - 16140. doi:10.1002/chem.201904139
Peer Reviewed verified by ORBi

Dauvin, M., Delvaux, C., Joris, B., Far, J., De Pauw, E., & Amoroso, A. M. (25 September 2019). Impact of penicillin stress on peptidoglycan peptides recycling in Bacillus spp [Poster presentation]. Great Wall Symposium.

Raymackers, A., Maréchal, M., Verlaine, O., Amoroso, A. M., & Joris, B. (July 2019). New insights to understand enterococcal ß-lactam resistance [Poster presentation]. 20th Conference on Bacilli and Gram Positive Bacteria, Washington DC, United States.

Mescola, A.* , Dauvin, M.* , Amoroso, A. M., Duwez, A.-S., & Joris, B. (June 2019). Single-molecule force spectroscopy to decipher the early signalling step in membrane-bound penicillin receptors embedded into a lipid bilayer. Nanoscale, 11, 12275. doi:10.1039/c9nr02466b
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Raymackers, A., Verlaine, O., Amoroso, A. M., & Joris, B. (07 February 2019). A new insight into β-lactam resistance in enterococci [Poster presentation]. InBioS Day.

Raymackers, A., Verlaine, O., Amoroso, A. M., & Joris, B. (2019). Understanfing PBP5 regulation and beta-lactam resistance mechanism in Enterococcus hirae and faecium [Poster presentation]. Annual Symposium of the Belgian Society for Microbiology.

Raymackers, A., Verlaine, O., Amoroso, A. M., & Joris, B. (2019). Understanding enterococcal β-lactam resistance [Poster presentation]. Interuniversity PhD Student Day.

Decuyper, L., Deketelaere, S., Vanparys, L., Jukič, M., Sosič, I., Sauvage, E., Amoroso, A. M., Verlaine, O., Joris, B., Gobec, S., & D'hooghe, M. (12 October 2018). In Silico Design and Enantioselective Synthesis of Functionalized Monocyclic 3-Amino-1-carboxymethyl-β-lactams as Inhibitors of Penicillin-Binding Proteins of Resistant Bacteria. Chemistry, 24 (57), 15254-15266. doi:10.1002/chem.201801868
Peer Reviewed verified by ORBi

Raymackers, A., Amoroso, A. M., Joris, B., & Verlaine, O. (Other coll.). (17 May 2018). Uncovering actors of enterococcal β-lactam resistance [Poster presentation]. Bioforum 2018.

Raymackers, A., Verlaine, O., Amoroso, A. M., & Joris, B. (2018). Transcriptome analysis of Enterococcus hirae to uncover β-lactam resistance mechanism [Poster presentation]. 2nd InBioS Day.

Raymackers, A., Verlaine, O., Amoroso, A. M., & Joris, B. (07 December 2017). Uncovering Enterococcus hirae beta-lactam resistance mechanism through transcriptom analysis [Poster presentation]. IAP meeting Integrative Protein Science: from small molecules to complex biological systems, Liège, Belgium.

Raymackers, A., Maréchal, M., Verlaine, O., Amoroso, A. M., & Joris, B. (13 June 2017). Study of the regulation of β-lactam resistance in Enterococcus hirae [Poster presentation]. 19th International Conference on Bacilli and Gram Positive Bacteria, Berlin, Germany.

Raymackers, A., Maréchal, M., Verlaine, O., Amoroso, A. M., & Joris, B. (11 May 2017). Study of the regulation of the operon ftsW-psr-pbp5 in Enterococcus hirae [Poster presentation]. Interuniversity PhD student day.

Di Gregorio, S., Fernandez, S., Cuirolo, A., Verlaine, O., Amoroso, A. M., Mengin-Lecreulx, D., Famiglietti, A., Joris, B., & Mollerach, M. (January 2017). Different Vancomycin-Intermediate Staphylococcus aureus Phenotypes Selected from the Same ST100-hVISA Parental Strain. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 23 (1), 44-50. doi:10.1089/mdr.2016.0160
Peer Reviewed verified by ORBi

Maréchal, M., Amoroso, A. M., Morlot, C., Vernet, T., Coyette, J., & Joris, B. (12 October 2016). Enterococcus hirae LcpA (Psr), a new peptidoglycan-binding protein localized at the division site. BMC Microbiology, 16 (1), 239. doi:10.1186/s12866-016-0844-y
Peer Reviewed verified by ORBi

Sosic, I., Anderluh, M., Sova, M., Gobec, M., Mlinaric Rascan, I., Derouaux, A., Amoroso, A. M., Terrak, M., Breukink, E., & Gobec, S. (2015). Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5b01482
Peer Reviewed verified by ORBi

Dauvin, M., Amoroso, A. M., & Joris, B. (23 June 2015). Fate of the coactivator in the induction of BlaP β-lactamase in Bacillus licheniformis 749/I [Poster presentation]. 8th International Conference on gram-positive Microorganisms, Montecatini Terme, Italy.

Dauvin, M., Vandamme, F., Abujahrur, N., Amoroso, A. M., & Joris, B. (13 May 2015). Modeling β-lactamase induction in Bacillus licheniformis 749/I [Poster presentation]. Bioforum, Liège, Belgium.

Fer, M., Bouhss,, A. B., Patrão, M., Le Corre, L., Pietrancosta, N., Amoroso, A. M., Joris, B., Mengin-Lecreulx, D., Calvet-Vitale, S., & Gravier-Pelletier, C. (May 2015). 5′-Methylene-triazole-substituted-aminoribosyl uridines as MraY inhibitors: synthesis, biological evaluation and molecular modeling. Organic and Biomolecular Chemistry, 13 (26), 7193. doi:10.1039/c5ob00707k
Peer Reviewed verified by ORBi

Terrasse, R., Amoroso, A. M., Vernet, T., & Di Guilmi, A. M. (2015). Streptococcus pneumoniae GAPDH Is Released by Cell Lysis and Interacts with Peptidoglycan. PLoS ONE, 10 (4), 0125377. doi:10.1371/journal.pone.0125377
Peer Reviewed verified by ORBi

Vassal-Stermann, E., Lacroix, M., Gout, E., Laffly, E., Pedersen, C. M., Martin, L., Amoroso, A. M., Schmidt, R. R., Zahringer, U., Gaboriaud, C., Di Guilmi, A.-M., & Thielens, N. M. (2014). Human L-ficolin recognizes phosphocholine moieties of pneumococcal teichoic acid. Journal of Immunology, 193 (11), 5699-708. doi:10.4049/jimmunol.1400127
Peer Reviewed verified by ORBi

Henry, X., Verlaine, O., Amoroso, A. M., Coyette, J., & Joris, B. (December 2013). Activity of ceftaroline against Enterococcus faecium PBP5. Antimicrobial Agents and Chemotherapy, 57 (12), 6358. doi:10.1128/AAC.00923-13
Peer Reviewed verified by ORBi

Dauvin, M., Amoroso, A. M., & Joris, B. (18 April 2013). Modeling β-lactamase induction in Bacillus licheniformis [Poster presentation]. Bioforum, Liège, Belgium.

Zervosen, A., Sauvage, E., Bouillez, A., Herman, A., Amoroso, A. M., Joris, B., Charlier, P., & Luxen, A. (18 April 2012). Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C [Poster presentation]. Biomedica 2012, Liège, Belgium.

Amoroso, A. M., Boudet, J., Berzigotti, S., Duval, V., Teller, N., Mengin-Lecreulx, D., Luxen, A., Simorre, J.-P., & Joris, B. (2012). A peptidoglycan fragment triggers beta-lactam resistance in Bacillus licheniformis. PLoS Pathogens, 8 (3), 1002571. doi:10.1371/journal.ppat.1002571
Peer Reviewed verified by ORBi

Zervosen, A., Bouillez, A., Herman, A., Amoroso, A. M., Joris, B., Sauvage, E., Charlier, P., & Luxen, A. (2012). Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C. Bioorganic and Medicinal Chemistry, 20 (12), 3915-24. doi:10.1016/j.bmc.2012.04.018
Peer Reviewed verified by ORBi

Berzigotti, S., Benlafya, K., Sepulchre, J., Amoroso, A. M., & Joris, B. (2012). Bacillus licheniformis BlaR1 L3 loop is a Zinc metalloprotease activated by self-proteolysis. PLoS ONE, 7, 36400. doi:10.1371/journal.pone.0036400
Peer Reviewed verified by ORBi

Sosic, I., Turk, S., Sinreih, M., Trost, N., Verlaine, O., Amoroso, A. M., Zervosen, A., Luxen, A., Joris, B., & Gobec, S. (2012). Exploration of the chemical space of novel naphthalene-sulfonamide and anthranilic acid-based inhibitors of penicillin-binding Proteins. Acta Chimica Slovenica, 59 (2), 380-388.
Peer Reviewed verified by ORBi

Turk, S., Verlaine, O., Gerards, T., Zivec, M., Humljan, J., Sosic, I., Amoroso, A. M., Zervosen, A., Luxen, A., Joris, B., & Gobec, S. (2011). New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria. PLoS ONE, 6 (5), 19418. doi:10.1371/journal.pone.0019418
Peer Reviewed verified by ORBi

Contreras-Martel, C., Amoroso, A. M., Woon, E. C. Y., Zervosen, A., Inglis, S., Martins, A., Verlaine, O., Rydzik, A. M., Job, V., Luxen, A., Joris, B., Schofield, C. J., & Dessen, A. (2011). Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome beta-Lactam Resistance in Staphylococcus aureus (MRSA). ACS Chemical Biology. doi:10.1021/cb2001846
Peer Reviewed verified by ORBi

Derouaux, A., Turk, S., Olrichs, N. K., Gobec, S., Breukink, E., Amoroso, A. M., Offant, J., Bostock, J., Mariner, K., Chopra, I., Vernet, T., Zervosen, A., Joris, B., Frère, J.-M., Nguyen Van, M., & Terrak, M. (2011). Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor. Biochemical Pharmacology, 81 (9), 1098-105. doi:10.1016/j.bcp.2011.02.008
Peer Reviewed verified by ORBi

Sosic, I., Barreteau, H., Simcic, M., Sink, R., Cesar, J., Zega, A., Grdadolnik, S. G., Contreras-Martel, C., Dessen, A., Amoroso, A. M., Joris, B., Blanot, D., & Gobec, S. (2011). Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid. European Journal of Medicinal Chemistry, 46 (7), 2880-94. doi:10.1016/j.ejmech.2011.04.011
Peer Reviewed verified by ORBi

Henry, X., Amoroso, A. M., Coyette, J., & Joris, B. (2010). Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium. Antimicrobial Agents and Chemotherapy, 54, 953-955. doi:10.1128/AAC.00983-09
Peer Reviewed verified by ORBi

Kern, T., Giffard, M., Hediger, S., Amoroso, A. M., Giustini, C., Khai Bui, N., Joris, B., Vollmer, & Simorre, J.-P. (2010). Dynamics Characterization of Fully Hydrated Bacterial Cell Walls by Solid-State NMR: Evidence for Cooperative Binding of Metal Ions. Journal of the American Chemical Society, 132, 10911-10919. doi:10.1021/ja104533w
Peer Reviewed verified by ORBi

Derouaux, A., Turk, S., Offant, J., Amoroso, A. M., Breukink, E., Bostock, J., Chopra, I., Zervosen, A., Joris, B., Nguyen Van, M., Vernet, T., Gobec, S., & Terrak, M. (November 2009). Identification and characterization of novel peptidoglycan glycosyltransferase inhibitors with antibacterial activity [Poster presentation]. Exploration and exploitation of bacterial cell wall biosynthesis, Warwick, United Kingdom.

Sauvage, E., Zervosen, A., Dive, G., Herman, R., Amoroso, A. M., Joris, B., Fonzé, E., Pratt, R., Luxen, A., Charlier, P., & Kerff, F. (2009). Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate. Journal of the American Chemical Society, 131 (42), 15262-15269. doi:10.1021/ja9051526
Peer Reviewed verified by ORBi

Kerff, F., Amoroso, A. M., Herman, R., Sauvage, E., Petrella, S., Filée, P., Charlier, P., Joris, B., Tabuchi, A., Nikolaidis, N., & Cosgrove, D. J. (2008). Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization. Proceedings of the National Academy of Sciences of the United States of America, 105 (44), 16876-81. doi:10.1073/pnas.0809382105
Peer Reviewed verified by ORBi

Boudet, J., Duval, V., Van Melckebeke, H., Blackledge, M., Amoroso, A. M., Joris, B., & Simorre, J. P. (2007). Conformational and thermodynamic changes of the repressor/DNA operator complex upon monomerization shed new light an regulation mechanisms of bacterial resistance against beta-lactam antibiotics. Nucleic Acids Research, 35 (13), 4384-4395. doi:10.1093/nar/gkm448
Peer Reviewed verified by ORBi

Rubinstein, G., Amoroso, A. M., Bavdaz, B., De Bunder, S., Blazquez, N., & Gutkind, G. O. (2005). Low macrolide resistance in Streptococcus pyogenes in Southern Argentina. International Journal of Antimicrobial Agents, 25 (5), 450-2. doi:10.1016/j.ijantimicag.2005.01.010
Peer Reviewed verified by ORBi

Duez, C., Hallut, S., Rhazi, N., Amoroso, A. M., Bouillenne, F., & Coyette, J. (July 2004). The ponA gene of Enterococcus faecalis JH2-2 codes for a low-affinity class a penicillin-binding protein. Journal of Bacteriology, 186 (13), 4412-4416. doi:10.1128/JB.186.13.4412-4416.2004
Peer Reviewed verified by ORBi

Martinez, S., Amoroso, A. M., Famiglietti, A., de Mier, C., Vay, C., & Gutkind, G. O. (2004). Genetic and phenotypic characterization of resistance to macrolides in Streptococcus pyogenes from Argentina. International Journal of Antimicrobial Agents, 23 (1), 95-8. doi:10.1016/j.ijantimicag.2003.05.009
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Sapunaric, F., Franssen, C., Stefanic, P., Amoroso, A. M., Dardenne, O., & Coyette, J. (2003). Redefining the role of psr in beta-lactam resistance and cell autolysis of Enterococcus hirae. Journal of Bacteriology, 185 (20), 5925-35. doi:10.1128/JB.185.20.5925-5935.2003
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Duez, C., Zorzi, W., Sapunaric, F., Amoroso, A. M., Thamm, I., & Coyette, J. (September 2001). The Penicillin Resistance of Enterococcus Faecalis Jh2-2r Results from an Overproduction of the Low-Affinity Penicillin-Binding Protein Pbp4 and Does Not Involve a Psr-Like Gene. Microbiology, 147 (Pt 9), 2561-9. doi:10.1099/00221287-147-9-2561
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Amoroso, A. M., & Gutkind, G. O. (2001). Chromogenic detection of aminoglycoside phosphotransferases. Methods in Molecular Medicine, 48, 113-7. doi:10.1385/1-59259-077-2:113
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Amoroso, A. M., Demares, D., Mollerach, M., Gutkind, G., & Coyette, J. (2001). All detectable high-molecular-mass penicillin-binding proteins are modified in a high-level beta-lactam-resistant clinical isolate of Streptococcus mitis. Antimicrobial Agents and Chemotherapy, 45 (7), 2075-81. doi:10.1128/AAC.45.7.2075-2081.2001
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Pappa, H., Segall, A., Pizzorno, M. T., Radice, M., Amoroso, A. M., & Gutkind, G. O. (1994). Antimicrobial activity of 5,6-dihydrobenzo-[a]-carbazoles. Farmaco (Il), 49 (5), 333-6.
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