Intraveinous paracetamol: a review of efficacy and safety in therapeutic use

[en] Paracetamol is well established as a leading nonprescription antipyretic analgesic drug and is available in oral, rectal or intravenous forms. However, except for oral paracetamol, there is a marked discrepancy between the extent to which paracetamol is used and the available evidence for an analgesic effect in postoperative pain. This review mainly focuses on intravenous paracetamol. Its efficacy and safety are analyzed, as well as its use in therapeutics, alone or in combination. The morphine-sparing, additive and antihyperalgesia effects of intravenous paracetamol are also reviewed. The analyses are divided into several sections, comparing the efficacy of intravenous paracetamol with placebo, other forms of paracetamol or analgesic agents and analyzing its efficacy in multimodal therapy combined with NSAIDs or a morphinic agent.

Disciplines :

General & internal medicine

Author, co-author :

Malaise, Olivier ; Université de Liège - ULiège > Cert.ECG

Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique - Département des sciences de la santé publique

Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique

Language :

English

Title :

Intraveinous paracetamol: a review of efficacy and safety in therapeutic use

Publication date :

2007

Journal title :

Future Neurology

ISSN :

1479-6708

eISSN :

1748-6971

Publisher :

Future Medicine Ltd

Volume :

Issue :

Pages :

673-688

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 03 September 2009

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