Reference : Chemical composition, vasorelaxant, antioxidant and antiplatelet effects of essential...
Scientific journals : Article
Human health sciences : Alternative medicine
Physical, chemical, mathematical & earth Sciences : Chemistry
Life sciences : Agriculture & agronomy
Chemical composition, vasorelaxant, antioxidant and antiplatelet effects of essential oil of Artemisia campestris L. from Oriental Morocco
Dib, Ikram []
Fauconnier, Marie-Laure mailto [Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie générale et organique >]
Sindic, Marianne mailto [Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Laboratoire Qualité et sécurité des produits agro-aliment. >]
Belmekki, Fatima []
Assaidi, Asmae []
Berrabah, Mohamed []
Mekhfi, Hassane []
Aziz, Mohammed []
Legssyer, Abdelkhaleq []
Bnouham, Mohamed []
Ziyyat, Abderrahim []
BMC Complementary and Alternative Medicine
art. 82
Yes (verified by ORBi)
[en] Artemisia campestris L ; GC/MS ; Antioxidant ; Antiplatelet ; Vasorelaxant
[en] Background: Artemisia campestris L. (Asteraceae) is a medicinal herb traditionally used to treat hypertension and many other diseases. Hence, this study is aimed to analyze the essential oil of A. campestris L (AcEO) and to investigate the antiplatelet, antioxidant effects and the mechanisms of its vasorelaxant effect.
Methods: The chemical composition of AcEO was elucidated using GC/MS analysis. Then, the antioxidant effect was tested on DPPH radical scavenging and on the prevention of β-carotene bleaching. The antiplatelet effect was performed on the presence of the platelet agonists: thrombin and ADP. The mechanism of action of the vasorelaxant effect was studied by using the cellular blockers specified to explore the involvement of NO/GC pathway and in the
presence of calcium channels blockers and potassium channels blockers.
Results: AcEO is predominated by the volatiles: spathulenol, ß-eudesmol and p-cymene. The maximal antioxidant effect was obtained with the dose 2 mg/ml of AcEO. The dose 1 mg/ml of AcEO showed a maximum antiplatelet effect of, respectively 49.73% ±9.54 and 48.20% ±8.49 on thrombin and ADP. The vasorelaxation seems not to be mediated via NOS/GC pathway neither via the potassium channels. However, pretreatment with calcium channels blockers attenuated this effect, suggesting that the vasorelaxation is mediated via inhibition of L-type Ca2+ channels and the activation of SERCA pumps of reticulum plasma.
Conclusion: This study confirms the antioxidant, antiplatelet and vasorelaxant effects of A.campestris L essential oil. However, the antihypertensive use of this oil should be further confirmed by the chemical fractionation and subsequent bio-guided assays.

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