Reference : INVESTIGATION DE LA QUALITE D’ANTIBIOTIQUES A BASE D'AMOXICILLINE DANS LE CADRE DE LA...
Scientific congresses and symposiums : Poster
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/207185
INVESTIGATION DE LA QUALITE D’ANTIBIOTIQUES A BASE D'AMOXICILLINE DANS LE CADRE DE LA SURVEILLANCE DU MARCHE OFFICIEL ET PERIPHERIQUE DE QUELQUES VILLES DE LA R.D. CONGO
French
[en] QUALITY EVALUATION OF ANTIBIOTICS BASED OF AMOXICILLIN , AS PART OF INVESTIGATION OF THE OFFICIAL AND PERIPHERAL DRUG MARKET IN SOME D.R.CONGO CITIES
Kalenda Tshilombo, Nicodème mailto [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (Bologne)]
Ciza Hamuli, Patient [Université de Liège - ULiège > > > stage conv. étrangères ou CFB en médecine]
Mavungu Landu, Don Jethro [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (paysage)]
Mwamba, Pierrot [Université de lumbabashi > > > >]
Waffo, Christelle [Université de Liège - ULiège > > > >]
Tidiane, Diallo [Université de Bamako > > > >]
Mbinze, Jéremie [Université de Kinshasa > > > >]
Hubert, Philippe mailto [Université de Liège > Département de pharmacie > Chimie analytique >]
Marini Djang'Eing'A, Roland mailto [Université de Liège > Département de pharmacie > Chimie analytique >]
Mar-2017
Yes
International
12ème Congrès Francophone sur les sciences séparatives et les couplages de AFSEP
du 28 au 30 mars 2017
Association francophone des sciences séparatives (AFSEP)
Paris
France
[fr] Validation ; Médicaments de qualité inférieure ; Contrôle qualité
[en] Drug counterfeiting is a sad and worrisome reality, especially in developing countries where quality control is not effective and sometimes not existing at all despite political will of governments. The consequences are harmful in particular for substandard medicines that pose more threats to populations in those countries due to their direct negative impact on patients such as failure of medical treatment including development of drug resistance and even death. Socio-economic consequences and negative reputation concerning the pharmaceutical industry are also observed. Unfortunately accurate detailed data on such medicines are not easy to obtain. Most of the time available data are often estimated from case reports or studies carried out in a specific area and during a defined period.Health authorities’ in the Democratic Republic of Congo are trying to identify this scourge by set up several strategies to fight against. One of them is built on the best knowledge of drugs from several horizons through the assessment of their quality to allow appropriate measurement. In this context, we have focused our study towards amoxicillin alone and/or combined with potassium clavulanate since it is one the very used medicines in pediatric medications. The formulations are powder for suspension.
Two analytical methods were developed based on the USP monography, applying isocratic liquid chromatography. Prior to their application in routine, we evaluated the suitability of these methods through validation applying the accuracy profile of total error. Since it was planned to transfer the methods to DRC, several operating factors were taken into account namely operator, day and equipment.
Interesting results were obtained in terms of trueness (relative biases below than 2.3%), precision (RSD of Intermediate precision below 2.8%), accuracy (beta-expectation tolerance intervals between -6.0% and 3.8%) for the concentration levels of interest. The latter were able to allow monitoring the quality of the two active ingredients here above in the 65 samples from Congolese market. They were collected in Kinshasa, Lubumbashi, Matadi and Kolwezi at official and non-official medicines distributors, in peripheral area. The dramatic results obtained confirm that substandard and counterfeit medicines remain a crucial problem on public health in low-income countries. Appropriate measures are really needed to set up the drug quality improvement.
Centre Interdisciplinaire de Recherche sur le Médicament - CIRM
Académie de Recherches et d'Enseignement Supérieur (ARES) ; Université de Liège (Ulg)
Développement, validation et transfert de méthodes analytiques génériques pour lutter contre la falsification des médicaments : Application en zones périurbaines - RDC
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/207185

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Abstract_SEP_03_2017vf.pdfPublisher postprint587.54 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.