Article (Scientific journals)
MicroRNAs in Valvular Heart Diseases: Potential Role as Markers and Actors of Valvular and Cardiac Remodeling.
Oury, Cécile; Servais, Laurence; Bouznad, Nassim et al.
2016In International Journal of Molecular Sciences, 17 (7)
Peer Reviewed verified by ORBi
 

Files


Full Text
ijms-17-01120_Oury_2016.pdf
Publisher postprint (1.31 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
biomarkers; cellular and animal models; microRNAs; valvular heart diseases
Abstract :
[en] miRNAs are a class of over 5000 noncoding RNAs that regulate more than half of the protein-encoding genes by provoking their degradation or preventing their translation. miRNAs are key regulators of complex biological processes underlying several cardiovascular disorders, including left ventricular hypertrophy, ischemic heart disease, heart failure, hypertension and arrhythmias. Moreover, circulating miRNAs herald promise as biomarkers in acute myocardial infarction and heart failure. In this context, this review gives an overview of studies that suggest that miRNAs could also play a role in valvular heart diseases. This area of research is still at its infancy, and further investigations in large patient cohorts and cellular or animal models are needed to provide strong data. Most studies focused on aortic stenosis, one of the most common valvular diseases in developed countries. Profiling and functional analyses indicate that miRNAs could contribute to activation of aortic valve interstitial cells to a myofibroblast phenotype, leading to valvular fibrosis and calcification, and to pressure overload-induced myocardial remodeling and hypertrophy. Data also indicate that specific miRNA signatures, in combination with clinical and functional imaging parameters, could represent useful biomarkers of disease progression or recovery after aortic valve replacement.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Oury, Cécile  ;  Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences
Servais, Laurence ;  Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences
Bouznad, Nassim
Hego, Alexandre 
Nchimi Longang, Alain ;  Université de Liège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Lancellotti, Patrizio  ;  Université de Liège > Département des sciences cliniques > Imagerie cardiaque fonctionnelle par échographie
Language :
English
Title :
MicroRNAs in Valvular Heart Diseases: Potential Role as Markers and Actors of Valvular and Cardiac Remodeling.
Publication date :
2016
Journal title :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Volume :
17
Issue :
7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 February 2017

Statistics


Number of views
68 (7 by ULiège)
Number of downloads
3 (3 by ULiège)

Scopus citations®
 
36
Scopus citations®
without self-citations
35
OpenCitations
 
26

Bibliography


Similar publications



Contact ORBi