Reference : Biocompatibility of polymer-infiltrated-ceramicnetwork (PICN) materials with Human Gi...
Scientific journals : Article
Human health sciences : Dentistry & oral medicine
Biocompatibility of polymer-infiltrated-ceramicnetwork (PICN) materials with Human Gingival Keratinocytes (HGKs)
GRENADE, Charlotte mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service prothèse fixée >]
De Pauw-Gillet, Marie-Claire mailto [Université de Liège > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
PIRARD, Catherine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de toxicologie >]
Bertrand, Virginie mailto [Université de Liège > Département de chimie (sciences) > Département de chimie (sciences) >]
Charlier, Corinne mailto [Université de Liège > Département de pharmacie > Chimie toxicologique >]
VAN HEUSDEN, Alain mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service prothèse fixée >]
Mainjot, Amélie mailto [Université de Liège > Département de sciences dentaires > Biomatériaux dentaires >]
Dental Materials
Elsevier Science
Yes (verified by ORBi)
United Kingdom
[en] Biocompatibility ; Polymer infiltrated ceramic network ; CAD–CAM composite ; Lithium disilicate glass-ceramic ; Zirconia ; Titanium ; Human Gingival Keratinocytes ; Monomer release ; Cytotoxicity ; Dental implant prostheses
[en] Objective. Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials, a new
class of CAD–CAM composites, is poorly explored in the literature, in particular, no data are
available regarding Human Gingival Keratinocytes (HGK). The first objective of this study
was to evaluate the in vitro biocompatibility of PICNs with HGKs in comparison with other
materials typically used for implant prostheses. The second objective was to correlate results
with PICN monomer release and indirect cytotoxicity.
Methods. HGK attachment, proliferation and spreading on PICN, grade V titanium (Ti), yttrium
zirconia (Zi), lithium disilicate glass-ceramic (eM) and polytetrafluoroethylene (negative control)
discs were evaluated using a specific insert-based culture system. For PICN and eM
samples, monomer release in the culture medium was quantified by high performance liquid
chromatography and indirect cytotoxicity tests were performed.
Results. Ti and Zi exhibited the best results regarding HGK viability, number and coverage.
eM showed inferior results while PICN showed statistically similar results to eM but also to
Ti regarding cell number and to Ti and Zi regarding cell viability. No monomer release from
PICN discs was found, nor indirect cytotoxicity, as for eM.
Significance. The results confirmed the excellent behavior of Ti and Zi with gingival cells.
Even if polymer based, PICN materials exhibited intermediate results between Ti–Zi and eM.
These promising results could notably be explained by PICN high temperature–high pressure
(HT–HP) innovative polymerization mode, as confirmed by the absence of monomer release
and indirect cytotoxicity

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