Article (Scientific journals)
Genome-wide Association Study of Acute Renal Graft Rejection.
Ghisdal, Lidia; Baron, Christophe; Lebranchu, Yvone et al.
2017In American Journal of Transplantation, 17 (1), p. 201-2019
Peer Reviewed verified by ORBi
 

Files


Full Text
Genome-Wide Association Study of Acute Renal Graft Rejection.pdf
Publisher postprint (184.3 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Acute renal rejection is a major risk factor for chronic allograft dysfunction and long-term graft loss. We performed a genome-wide association study to detect loci associated with biopsy-proven acute T cell-mediated rejection occurring in the first year after renal transplantation. In a discovery cohort of 4127 European renal allograft recipients transplanted in eight European centers, we used a DNA pooling approach to compare 275 cases and 503 controls, on Illumina 2.5 M arrays. In an independent replication cohort of 2765 patients transplanted in two European countries, we identified 313 cases and 531 controls, in whom we genotyped individually the most significant SNPs from the discovery cohort. In the discovery cohort, we found 5 candidate loci tagged by a number of contiguous SNPs (>5) that was never reached in iterative in silico permutations of our experimental data. In the replication cohort, two loci remained significantly associated with acute rejection in both univariate and multivariate analysis. One locus encompasses PTPRO, coding for a receptor-type tyrosine kinase essential for B cell receptor signalling. The other locus involves ciliary gene CCDC67, in line with the emerging concept of a shared building design between the immune synapse and the primary cilium. This article is protected by copyright. All rights reserved.
Disciplines :
Genetics & genetic processes
Author, co-author :
Ghisdal, Lidia;  Hopital Erasme
Baron, Christophe;  Université de Tours
Lebranchu, Yvone;  Université de Tours
Viklicky, Ondřej
Konarikova, A.
Naesens, A.
Kuypers, Dirk
Dinic, M.
Alamartine, E.
Touchard, G.
Antoine, T.
Essig, M.
Rerolle, J.P.
Merville, P.
Taupin, J.L.
Le Meur, Y.
Grall - Jezequel, A.
Glowacki, F.
Noel, C.
Legendre, C.
Anglicheau, D.
Broeders, N.
Coppieters, Wouter ;  Université de Liège - ULiège > Dpt. de gestion vétérinaire des Ressources Animales (DRA) > GIGA-R : Génomique animale
Docampo, E.
Georges, Michel  ;  Université de Liège - ULiège > Dpt. de gestion vétérinaire des Ressources Animales (DRA) > GIGA-R : Génomique animale
Ajarchouh, Z.
Massart, Annick
Racapé J.
Abramowicz, D.
Abramowicz M.
More authors (20 more) Less
Language :
English
Title :
Genome-wide Association Study of Acute Renal Graft Rejection.
Publication date :
2017
Journal title :
American Journal of Transplantation
ISSN :
1600-6135
eISSN :
1600-6143
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
17
Issue :
1
Pages :
201-2019
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 January 2017

Statistics


Number of views
86 (7 by ULiège)
Number of downloads
73 (1 by ULiège)

Scopus citations®
 
40
Scopus citations®
without self-citations
37
OpenCitations
 
37
OpenAlex citations
 
44

Bibliography


Similar publications



Contact ORBi