[en] Defining reference range is an essential tool for diagnostic. Age and sexe influences on thyroid hormone levels have been already discussed. In this study, we are defining a new pediatric reference range for TSH, FT3 and FT4 for Cobas C6000 analyzer. To do so, we have taken in account 0 to 18 year old outclinic patients. During the first year of life, thyroid hormone levels change dramatically before getting stabilized around 3 years old. We also compared our results
to those obtained in a Canadian large-scale prospective study (the CALIPER initiative).
Disciplines :
Médecine de laboratoire & technologie médicale
Auteur, co-auteur :
LADANG, Aurélie ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs Biologie clinique - Pool assistants
VRANKEN, Laura ; Centre Hospitalier Universitaire de Liège - CHU > Secteur commun NDB
LUYCKX, Françoise ; Centre Hospitalier Universitaire de Liège - CHU > Service de chimie clinique
Hong, T, Paneth, N. - Maternal and infant thyroid disorders and cerebral palsy. Semin Perinatol, 2008, 32, 438-445.
Grosse SD, Van Vliet G. - Prevention of intellectual disability through screening for congenital hypothyroidism: how much and at what level ? Arch Dis Child, 2011, 96, 374-379.
Soldin OP, Jang M, Guo T, et al. - Pediatric reference intervals for free thyroxine and free triiodothyronine. Thyroid, 2009, 19, 699-702.
Kapelari K, Krichlechner C, Hogler W, et al. - Pediatric reference intervals for thyroid hormone levels from birth to adulthood: a retrospective study. BMC Endocr Disord, 2008, 8, 15.
Aldrimer M, Ridefelt P, Rödöö P, et al. - Reference intervals on the Abbot Architect for serum thyroid hormones, lipids and prolactin in healthy children in a population-based study. Scand J Clin Lab Investig, 2012, 72, 326-332.
Kulasingam V, Jung B, Blasutig I, et al. - Pediatric reference intervals for 28 chemistries and immunoassays on the Roche cobas 6000 analyzer. A CALIPER pilot study. Clin Biochem, 2010, 43, 1045-1050.
Thienpont LM, Faix JD, Beastall G. - Standardization of FT4 and harmonization of TSH measurements. A request for input from endocrinologists and other physicians. Clin Endocrinol, 2016, 84, 305-306.
Thienpont LM, Beastall G, Christofides N, et al. - Proposal of a candidate international conventional reference measurement procedure for free thyroxine in serum. Clin Chem Lab Med, 2007, 45, 934-936.
Thienpont LM, Van Uytfanghe K, Beastall G, et al. - Report of the IFCC Working Group for standardization of thyroid function tests; Part 2: free thyroxine and free triiodothyronine. Clin Chem, 2010, 56, 912-920.
Colantonio DA, Kiriakopoulou L, Chan M, et al. - Closing the gaps in pediatric laboratory reference intervals: A caliper database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem, 2012, 58, 854-868.
Shaw JLV, Cohen A, Konforte D, et al. - Validity of establishing pediatric reference intervals based on hospital patient data: A comparison of the modified Hoffmann approach to CALIPER reference intervals obtained in healthy children. Clin Biochem, 2014, 47, 166-172.
Harris EK, Boyd JC. - On dividing reference data into subgroups to produce separate reference ranges. Clin Chem, 1990, 36, 265-270.
Lahti A, Hyltoft Petersen P, Boyd JC, et al. - Objective criteria for partitioning Gaussian-distributed reference values into subgroups. Clin Chem, 2002, 48, 338-352.
Elmlinger MW, Kühnel W, Lambrecht HG, et al. - Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH). Clin Chem Lab Med, 2001, 39, 973-979.
Djemli A, Van Vliet G, Belgoudi J. - Reference intervals for free thyroxine, total triiodothyronine, thyrotropin and thyroglobulin for Quebec newborns, children and teenagers. Clin Biochem, 2004, 37, 328-330.
Bona G, Prodam F, Monzani A. - Subclinical hypothyroidism in children: Natural history and when to treat. J Clin Res Pediatr Endocrinol, 2013, 5, 23-28.
Gawlik A, Such K, Dejner A, et al. - Subclinical hypothyroidism in children and adolescents: Is it clinically relevant? Int J Endocrinol, 2015, 2015, 691. 071. doi:10, 1155/2015/691071
Marras V, Casini M, Pilia S, et al. - Thyroid function in obese children and adolescents. Horm Res Pædiatrics, 2010, 73, 193-197.
Stichel H, l'Allemand D, Grüters A. - Thyroid function and obesity in children and adolescents. Horm Res, 2000, 54, 14-19.
Bhowmick SK, Dasari G, Levens KL, et al. - The prevalence of elevated serum thyroid-stimulating hormone in childhood/adolescent obesity and of autoimmune thyroid diseases in a subgroup. J Natl Med Assoc, 2007, 99, 773-776.
