Exposure to endocrine disrupting chemicals and neurodevelopmental alterations.

[en] The developing brain is remarkably malleable as neural circuits are formed and these circuits are strongly dependent on hormones for their development. For those reasons, the brain is very vulnerable to the effects of endocrine-disrupting chemicals (EDCs) during critical periods of development. This review focuses on three ubiquitous endocrine disruptors that are known to disrupt the thyroid function and are associated with neurobehavioral deficits: polychlorinated biphenyls, polybrominated diphenyl ethers, and bisphenol A. The human and rodent data suggesting effects of those EDCs on memory, cognition, and social behavior are discussed. Their mechanisms of action go beyond relative hypothyroidism with effects on neurotransmitter release and calcium signaling.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology
Endocrinology, metabolism & nutrition
Pediatrics

Author, co-author :

Pinson, Anneline ; Université de Liège > Département des sciences cliniques > Pédiatrie

Bourguignon, Jean-Pierre ; Université de Liège > Département des sciences cliniques > Département des sciences cliniques

Parent, Anne-Simone ; Université de Liège > Département des sciences cliniques > Pédiatrie

Language :

English

Title :

Exposure to endocrine disrupting chemicals and neurodevelopmental alterations.

Publication date :

July 2016

Journal title :

Andrology

ISSN :

2047-2919

eISSN :

2047-2927

Publisher :

John Wiley and Sons, Hoboken, United States - New Jersey

Volume :

Issue :

Pages :

706-22

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 20 January 2017

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62 (6 by ULiège)

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2 (2 by ULiège)

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