Article (Scientific journals)
Intraperitoneal antineoplastic drug delivery: experience with a cyclophosphamide, vincristine and prednisolone protocol in cats with malignant lymphoma.
Teske, Erik; van Lankveld, A. J.; Rutteman, G. R.
2014In Veterinary and Comparative Oncology, 12 (1), p. 37-46
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Keywords :
Animals; Antineoplastic Agents/administration & dosage/therapeutic use; Cat Diseases/drug therapy; Cats; Cyclophosphamide/administration & dosage/therapeutic use; Female; Injections, Intraperitoneal; Lymphoma/drug therapy/veterinary; Male; Prednisolone/administration & dosage/therapeutic use; Vincristine/administration & dosage/therapeutic use; cat; chemotherapy; intraperitoneal; lymphoma; safety
Abstract :
[en] In this retrospective study, the efficacy and safety were examined for an intraperitoneal chemotherapy protocol-cyclophosphamide, vincristine and prednisolone (IP-COP) in 26 cats with malignant lymphoma. Certainly in cats fiercely resisting IV administration the IP route is a more practical method, safer for the administrator and less stressful for the cat. Complete remission (CR) rate was 76.9% (n = 20). Median duration of first remission was 421 days. Estimated 1- and 2-year disease free period were 67.1 and 48.0%, respectively. Median duration of survival was 388 days and estimated overall 1- and 2-year survival periods were 54.7 and 46.9% respectively. Young cats had a more favourable prognosis. Reaching CR was essential for long-term survival. No specific IP-related adverse events (AE) were seen. AE were generally scored as mild and were not excessively abundant. These results indicate that the IP route is a safe and effective alternative for the administration of COP protocol chemotherapeutics.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Teske, Erik ;  Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Dép. clinique des animaux de compagnie et des équidés (DCA)
van Lankveld, A. J.
Rutteman, G. R.
Language :
English
Title :
Intraperitoneal antineoplastic drug delivery: experience with a cyclophosphamide, vincristine and prednisolone protocol in cats with malignant lymphoma.
Publication date :
2014
Journal title :
Veterinary and Comparative Oncology
ISSN :
1476-5810
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
12
Issue :
1
Pages :
37-46
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2012 John Wiley & Sons Ltd.
Available on ORBi :
since 19 January 2017

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