[en] Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a pituitary gangliocytoma associated with a prolactinoma and a corticotroph adenoma in a patient affected by MEN1. The histologic study revealed shared features between adenomatous and neuronal cells, supporting the etiological hypothesis of a common origin or a phenomenon of transdifferentiation. Furthermore, gangliocytoma could be a new tumor related to MEN1. The clinical and histologic observations are discussed and the literature on the topic is reviewed.
Disciplines :
Endocrinologie, métabolisme & nutrition
Auteur, co-auteur :
Sergeant, Camille
Jublanc, Christel
Leclercq, Delphine
Boch, Anne-Laure
Bielle, Franck
Raverot, Gerald
Daly, Adrian ; Université de Liège > Département des sciences cliniques > Endocrinologie
Trouillas, Jacqueline
Villa, Chiara
Langue du document :
Anglais
Titre :
Transdifferentiation of Neuroendocrine Cells: Gangliocytoma Associated With Two Pituitary Adenomas of Different Lineage in MEN1.
Date de publication/diffusion :
2017
Titre du périodique :
American Journal of Surgical Pathology
ISSN :
0147-5185
eISSN :
1532-0979
Maison d'édition :
Lippincott Williams & Wilkins, Etats-Unis - New York
Delemer B. MEN1 and pituitary adenomas. Ann Endocrinol. 2012;73:59-61.
Goudet P, Dalac A, Le Bras M, et al. MEN1 disease occurring before 21 years old: a 160-patient cohort study from the Groupe d'étude des Tumeurs Endocrines. J Clin Endocrinol Metab. 2015;100:1568-1577.
Goudet P, Bonithon-Kopp C, Murat A, et al. Gender-related differences in MEN1 lesion occurrence and diagnosis: a cohort study of 734 cases from the Groupe d'etude des Tumeurs Endocrines. Eur J Endocrinol Eur Fed Endocr Soc. 2011;165:97-105.
Syro LV, Scheithauer BW, Kovacs K, et al. Pituitary tumors in patients withMEN1 syndrome. Clin Saõ Paulo Braz. 2012;67(suppl 1): 43-48.
Vergès B, Boureille F, Goudet P, et al. Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study. J Clin Endocrinol Metab. 2002;87:457-465.
Trouillas J, Labat-Moleur F, Sturm N, et al. Pituitary tumors and hyperplasia in multiple endocrine neoplasia type 1 syndrome (MEN1): a case-control study in a series of 77 patients versus 2509 non-MEN1 patients. Am J Surg Pathol. 2008;32:534-543.
Geddes JF, Jansen GH, Robinson SF, et al. "Gangliocytomas" of the pituitary: a heterogeneous group of lesions with differing histogenesis. Am J Surg Pathol. 2000;24:607-613.
Kontogeorgos G, Mourouti G, Kyrodimou E, et al. Ganglion cell containing pituitary adenomas: signs of neuronal differentiation in adenoma cells. Acta Neuropathol (Berl). 2006;112:21-28.
Mikami S, Kameyama K, Takahashi S, et al. Combined gangliocytoma and prolactinoma of the pituitary gland. Endocr Pathol. 2008;19: 117-121.
Asa SL, Scheithauer BW, Bilbao JM, et al. A case for hypothalamic acromegaly: a clinicopathological study of six patients with hypothalamic gangliocytomas producing growth hormonereleasing factor. J Clin Endocrinol Metab. 1984;58:796-803.
McCowen KC, Glickman JN, Black PM, et al. Gangliocytoma masquerading as a prolactinoma. Case report. J Neurosurg. 1999; 91:490-495.
Morikawa M, Tamaki N, Kokunai T, et al. Intrasellar pituitary gangliocyto-adenoma presenting with acromegaly: case report. Neurosurgery. 1997;40:611-614; discussion 614-615.
Puchner MJ, Herrmann HD. Intrasellar pituitary gangliocytoadenoma presenting with acromegaly: case report. Neurosurgery. 1998;42:1197-1199.
Asa SL, Kovacs K, Tindall GT, et al. Cushing's disease associated with an intrasellar gangliocytoma producing corticotrophinreleasing factor. Ann Intern Med. 1984;101:789-793.
Chiu S, Koos RD, Wise PM. Detection of prolactin receptor (PRL-R) mRNA in the rat hypothalamus and pituitary gland. Endocrinology. 1992;130:1747-1749.
Maruyama M, Matsumoto H, Fujiwara K, et al. Immunocytochemical localization of prolactin-releasing peptide in the rat brain. Endocrinology. 1999;140:2326-2333.
Schachter BS, Durgerian S, Harlan RE, et al. Prolactin mRNA exists in rat hypothalamus. Endocrinology. 1984;114:1947-1949.
Serri O, Berthelet F, Bélair M, et al. An unusual association of a sellar gangliocytoma with a prolactinoma. Pituitary. 2008;11:85-87.
Koutourousiou M, Kontogeorgos G, Wesseling P, et al. Collision sellar lesions: experience with eight cases and review of the literature. Pituitary. 2010;13:8-17.
Bevan JS, Asa SL, Rossi ML, et al. Intrasellar gangliocytoma containing gastrin and growth hormone-releasing hormone associated with a growth hormone-secreting pituitary adenoma. Clin Endocrinol (Oxf). 1989;30:213-224.
Bódi I, Martin AJ, Connor SEJ, et al. Mixed pituitary gangliocytoma/adenoma (prolactinoma) with histogenetic implications. Neuropathol Appl Neurobiol. 2002;28:252-255.
Kurosaki M, Saeger W, Lüdecke DK. Intrasellar gangliocytomas associated with acromegaly. Brain Tumor Pathol. 2002;19:63-67.
Horvath E, Kovacs K, Scheithauer BW, et al. Pituitary adenoma with neuronal choristoma (PANCH): composite lesion or lineage infidelity? Ultrastruct Pathol. 1994;18:565-574.
Scheithauer BW, Horvath E, Kovacs K, et al. Prolactin-producing pituitary adenoma and carcinoma with neuronal components-a metaplastic lesion. Pituitary. 1999;1:197-205.
Horvath E, Kovacs K, Tran A, et al. Ganglion cells in the posterior pituitary: result of ectopia or transdifferentiation? Acta Neuropathol (Berl). 2000;100:106-110.
Li JY, Racadot O, Kujas M, et al. Immunocytochemistry of four mixed pituitary adenomas and intrasellar gangliocytomas associated with different clinical syndromes: acromegaly, amenorrhea-galactorrhea, Cushing's disease and isolated tumoral syndrome. Acta Neuropathol (Berl). 1989;77:320-328.
Towfighi J, Salam MM, McLendon RE, et al. Ganglion cellcontaining tumors of the pituitary gland. Arch Pathol Lab Med. 1996;120:369-377.
Brady S, Lechan RM, Schwaitzberg SD, et al. Composite pheochromocytoma/ganglioneuroma of the adrenal gland associated with multiple endocrine neoplasia 2A: case report with immunohistochemical analysis. Am J Surg Pathol. 1997;21:102-108.
Tischler AS. Divergent differentiation in neuroendocrine tumors of the adrenal gland. Semin Diagn Pathol. 2000;17:120-126.
Balci S, Saglam A, Oruckaptan H, et al. Pituitary adenoma with gangliocytic component: report of 5 cases with focus on immunoprofile of gangliocytic component. Pituitary. 2015;18:23-30.
Puchner MJ, Lüdecke DK, Valdueza JM, et al. Cushing's disease in a child caused by a corticotropin-releasing hormone-secreting intrasellar gangliocytoma associated with an adrenocorticotropic hormone-secreting pituitary adenoma. Neurosurgery. 1993;33: 920-924; discussion 924-925.
