The somatotrope Growth Hormone-Releasing Hormone/Growth Hormone/Insulin-like Growth Factor 1 axis in immunoregulation and immunosenescence

Bodart, Gwennaëlle; Farhat, Khalil; Charlet-Renard, Jeanne de Chantal; Salvatori, Roberto; Geenen, Vincent; Martens, Henri

doi:10.1159/000452913

Contribution to collective works (Parts of books)

The somatotrope Growth Hormone-Releasing Hormone/Growth Hormone/Insulin-like Growth Factor 1 axis in immunoregulation and immunosenescence

Bodart, Gwennaëlle; Farhat, Khalil; Charlet-Renard, Jeanne de Chantal et al.

2017 • In Savino, Wilson; Guaraldi, Federica (Eds.) Endocrine Immunology

Peer reviewed

Permalink
https://hdl.handle.net/2268/204664

DOI
10.1159/000452913

PubMed
28245459

Files (1)Send to Details Statistics Bibliography Similar publications

Files

Full Text

Front Horm Res. Basel.pdf

Publisher postprint (396.94 kB)

Request a copy

All documents in ORBi are protected by a user license.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

GHRH; GH; IGF1; Immunomodulation; Immunosenescence

Abstract :

[en] Most scientific reports debate the thymotropic and immuno-stimulating properties of the somato- trope growth hormone-releasing hormone (GHRH)/growth hormone (GH)/insulin-like growth factor (IGF)-1 axis, but there is still some disagreement about the physiological role of this axis in basal conditions. Moreover, some authors have hypothesized that the physiological role of the somato- trope axis only appears in stressful conditions (such as sepsis or infective and inflammatory diseases). This chapter will provide an extended overview of the expression of the components (signals and receptors) of the somatotrope axis and their properties on cells of the innate and adaptive immune system. It will also summarize some clinical studies suggesting a benefit for a short-term GH treat- ment in acute immunodeficiencies, and the importance of GH supplementation in adult GH defi- ciency. A new transgenic mouse model, the hypothalamic GHRH-deficient (Ghrh–/–) mouse, which exhibits a severe deficiency of the somatotrope axis, will be presented since it will be of great help in further deciphering the regulation by the GHRH/GH/IGF-1 axis on both immune development and function. Finally, we will discuss the implication of aging-related somatopause in relation to the general context of Immunosenescence.

Research Center/Unit :

GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège

Disciplines :

Endocrinology, metabolism & nutrition
Immunology & infectious disease

Author, co-author :

Bodart, Gwennaëlle ; Université de Liège > Centre d'immunologie

Farhat, Khalil; Université de Liège - ULiège > Centre d'Immunologie

Charlet-Renard, Jeanne de Chantal ; Centre Hospitalier Universitaire de Liège - CHU > Service d'endocrinologie clinique

Salvatori, Roberto

Geenen, Vincent ; Université de Liège > Centre d'immunologie

Martens, Henri ; Université de Liège > Centre d'immunologie

Language :

English

Title :

The somatotrope Growth Hormone-Releasing Hormone/Growth Hormone/Insulin-like Growth Factor 1 axis in immunoregulation and immunosenescence

Publication date :

2017

Main work title :

Endocrine Immunology

Editor :

Savino, Wilson

Guaraldi, Federica

Publisher :

Karger, Basel, Switzerland

Collection name :

Frontiers in Hormone Research

Pages :

147-159

Peer reviewed :

Peer reviewed

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
Fonds Léon Fredericq
ARC Somasthym

Available on ORBi :

since 22 December 2016

Statistics

Number of views

111 (13 by ULiège)

Number of downloads

3 (3 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Murphy, W.J., Durum, S.K., Longo, D.L., Role of neuroendocrine hormones in murine T cell development. Growth hormone exerts thymopoietic effects in vivo (1992) J Immunol, 149, pp. 3851-3857
Pierpaoli, W., Baroni, C., Fabris, N., Sorkin, E., Hormones and immunological capacity. II. Reconstitution of antibody production in hormonally deficient mice by somatotropic hormone, thyrotropic hormone and thyroxin (1969) Immunology, 16, pp. 217-230
Foster, M.P., Jensen, E.R., Montecino-Rodriguez, E., Leathers, H., Horseman, N., Dorshkind, K., Humoral and cell-mediated immunity in mice with genetic deficiencies of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormone (2000) Clin Immunol, 96, pp. 140-149
Bodart, G., Goffinet, L., Morrhaye, G., Farhat, K., De Saint-Hubert, M., Debacq-Chainiaux, F., Somatotrope GHRH/GH/IGF-1 axis at the crossroads between immunosenescence and frailty (2015) Ann N y Acad Sci, 1351, pp. 61-67
Smith, P.E., The effect of hypophysectomy upon the involution of the thymus in the rat (1930) Anat Rec, 47, pp. 119-129
Baroni, C.D., Fabris, N., Bertoli, G., Effects of hormones on development and function of lymphoid tissues. Synergistic action of thyroxin and somatotropic hormone in pituitary dwarf mice (1969) Immunology, 17, pp. 303-314
Duquesnoy, R.J., Immunodeficiency of the thymus-dependent system of the Ames dwarf mouse (1972) J Immunol, 108, pp. 1578-1590
Kelley, K.W., Brief, S., Westly, H.J., Novakofski, J., Bechtel, P.J., Simon, J., GH3 pituitary adenoma cells can reverse thymic aging in rats (1986) Proc Natl Acad Sci U S A, 83, pp. 5663-5667
Gagnerault, M.C., Postel-Vinay, M.C., Dardenne, M., Expression of growth hormone receptors in murine lymphoid cells analyzed by flow cytofluorometry (1996) Endocrinology, 137, pp. 1719-1726
De Mello-Coelho, V., Gagnerault, M.C., Souberbielle, J.C., Strasburger, C.J., Savino, W., Dardenne, M., Growth hormone and its receptor are expressed in human thymic cells (1998) Endocrinology, 139, pp. 3837-3842
Maggiano, N., Piantelli, M., Ricci, R., Larocca, L.M., Capelli, A., Ranelletti, F.O., Detection of growth hormone-producing cells in human thymus by immunohistochemistry and non-radioactive in situ hybridization (1994) J Histochem Cytochem, 42, pp. 1349-1354
Hattori, N., Saito, T., Yagyu, T., Jiang, B.H., Kitagawa, K., Inagaki, C., GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils (2001) J Clin Endocrinol Metab, 86, pp. 4284-4291
Hansson, H.A., Nilsson, A., Isgaard, J., Billig, H., Isaksson, O., Skottner, A., Immunohistochemical localization of insulin-like growth factor i in the adult rat (1988) Histochemistry, 89, pp. 403-410
Verland, S., Gammeltoft, S., Functional receptors for insulin-like growth factors i and II in rat thymocytes and mouse thymoma cells (1989) Mol Cell Endocrinol, 67, pp. 207-216
Kooijman, R., Hooghe-Peters, E.L., Hooghe, R., Prolactin, growth hormone, and insulin-like growth factor-I in the immune system (1996) Adv Immunol, 63, pp. 377-454
De Mello Coelho, V., Villa-Verde, D.M., Farias-De-Oliveira, D.A., De Brito, J.M., Dardenne, M., Savino, W., Functional insulin-like growth factor-1/insulin-like growth factor-1 receptor-mediated circuit in human and murine thymic epithelial cells (2002) Neuroendocrinology, 75, pp. 139-150
Manfredi, R., Tumietto, F., Azzaroli, L., Zucchini, A., Chiodo, F., Manfredi, G., Growth hormone (GH) and the immune system: Impaired phagocytic function in children with idiopathic GH deficiency is corrected by treatment with biosynthetic GH (1994) J Pediatr Endocrinol, 7, pp. 245-251
Auernhammer, C.J., Feldmeier, H., Nass, R., Pachmann, K., Strasburger, C.J., Insulin-like growth factor i is an independent coregulatory modulator of natural killer (NK) cell activity (1996) Endocrinology, 137, pp. 5332-5336
Liu, Q.L., Wang, Y.S., Wang, J.X., Effect of growth hormone on the immune function of dendritic cells (2010) Chin Med J (Engl), 123, pp. 1078-1083
Ghiasuddin, S.M., Schepper, J.M., Yunger, L.M., Kelley, K.W., A newly defined property of somatotropin: Priming of macrophages for production of superoxide anion (1988) Science, 239 (4841), pp. 769-771
Inoue, T., Saito, H., Matsuda, T., Fukatsu, K., Han, I., Furukawa, S., Growth hormone and insulin-like growth factor i augment bactericidal capacity of human polymorphonuclear neutrophils (1998) Shock, 10, pp. 278-284
Warwick-Davies, J., Lowrie, D.B., Cole, P.J., Growth hormone is a human macrophage activating factor. Priming of human monocytes for enhanced release of H2O2 (1995) J Immunol, 154, pp. 1909-1918
Bjerknes, R., Aarskog, D., Priming of human polymorphonuclear neutrophilic leukocytes by insulin-like growth factor I: Increased phagocytic capacity, complement receptor expression, degranulation, and oxidative burst (1995) J Clin Endocrinol Metab, 80, pp. 1948-1955
Renier, G., Clement, I., Desfaits, A.C., Lambert, A., Direct stimulatory effect of insulin-like growth factor-I on monocyte and macrophage tumor necrosis factor-alpha production (1996) Endocrinology, 137, pp. 4611-4618
Liu, Z., Yu, Y., Jiang, Y., Li, J., Growth hormone increases circulating neutrophil activation and provokes lung microvascular injury in septic peritonitis rats (2002) J Surg Res, 105, pp. 195-199
Fornari, M.C., Scolnik, M.P., Palacios, M.F., Intebi, A.D., Diez, R.A., Growth hormone inhibits normal B-cell differentiation and neutrophils' chemotaxis in vitro (1994) Int J Immunopharmacol, 16, pp. 667-673
Wiedermann, C.J., Reinisch, N., Braunsteiner, H., Stimulation of monocyte chemotaxis by human growth hormone and its deactivation by somatostatin (1993) Blood, 82, pp. 954-960
Burgess, W., Jesse, K., Tang, Q., Broussard, S.R., Dantzer, R., Kelley, K.W., Insulin-like growth factor-I and the cytokines IL-3 and IL-4 promote survival of progenitor myeloid cells by different mechanisms (2003) J Neuroimmunol, 135, pp. 82-90
Matsuda, T., Saito, H., Inoue, T., Fukatsu, K., Han, I., Furukawa, S., Growth hormone inhibits apoptosis and up-regulates reactive oxygen intermediates production by human polymorphonuclear neutrophils (1998) JPEN J Parenter Enteral Nutr, 22, pp. 368-374
Shimizu, K., Adachi, K., Teramoto, A., Growth hormone enhances natural killer cell activity against glioma (2005) J Nippon Med Sch, 72, pp. 335-340
Montecino-Rodriguez, E., Clark, R.G., Powell-Braxton, L., Dorshkind, K., Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis (1997) J Immunol, 159, pp. 2712-2719
Sumita, K., Hattori, N., Inagaki, C., Effects of growth hormone on the differentiation of mouse B-lymphoid precursors (2005) J Pharmacol Sci, 97, pp. 408-416
Jardieu, P., Clark, R., Mortensen, D., Dorshkind, K., In vivo administration of insulin-like growth factor-I stimulates primary B lymphopoiesis and enhances lymphocyte recovery after bone marrow transplantation (1994) J Immunol, 152, pp. 4320-4327
Robbins, K., McCabe, S., Scheiner, T., Strasser, J., Clark, R., Jardieu, P., Immunological effects of insulin-like growth factor-I - Enhancement of immunoglobulin synthesis (1994) Clin Exp Immunol, 95, pp. 337-342
Yoshida, A., Ishioka, C., Kimata, H., Mikawa, H., Recombinant human growth hormone stimulates B cell immunoglobulin synthesis and proliferation in serum-free medium (1992) Acta Endocrinol (Copenh), 126, pp. 524-529
Ciofani, M., Zuniga-Pflucker, J.C., The thymus as an inductive site for T lymphopoiesis (2007) Annu Rev Cell Dev Biol, 23, pp. 463-493
Sabharwal, P., Varma, S., Growth hormone synthesized and secreted by human thymocytes acts via insulin-like growth factor i as an autocrine and paracrine growth factor (1996) J Clin Endocrinol Metab, 81, pp. 2663-2669
Smaniotto, S., De Mello-Coelho, V., Villa-Verde, D.M., Pleau, J.M., Postel-Vinay, M.C., Dardenne, M., Growth hormone modulates thymocyte development in vivo through a combined action of laminin and CXC chemokine ligand 12 (2005) Endocrinology, 146, pp. 3005-3017
Taub, D.D., Tsarfaty, G., Lloyd, A.R., Durum, S.K., Longo, D.L., Murphy, W.J., Growth hormone promotes human T cell adhesion and migration to both human and murine matrix proteins in vitro and directly promotes xenogeneic engraftment (1994) J Clin Invest, 94, pp. 293-300
Timsit, J., Savino, W., Safieh, B., Chanson, P., Gagnerault, M.C., Bach, J.F., Growth hormone and insulin-like growth factor-I stimulate hormonal function and proliferation of thymic epithelial cells (1992) J Clin Endocrinol Metab, 75, pp. 183-188
De Mello-Coelho, V., Villa-Verde, D.M., Dardenne, M., Savino, W., Pituitary hormones modulate cell-cell interactions between thymocytes and thymic epithelial cells (1997) J Neuroimmunol, 76, pp. 39-49
Tseng, Y.H., Ma, K., Schuler, L.A., Regulation of interleukin (IL)-1alpha, IL-1beta, and IL-6 expression by growth hormone and prolactin in bovine thymic stromal cells (1997) Mol Cell Endocrinol, 128, pp. 117-127
Dixit, V.D., Yang, H., Sun, Y., Weeraratna, A.T., Youm, Y.H., Smith, R.G., Ghrelin promotes thymopoiesis during aging (2007) J Clin Invest, 117, pp. 2778-2790
Dumont, F., Robert, F., Bischoff, P., T and B lymphocytes in pituitary dwarf Snell-Bagg mice (1979) Immunology, 38, pp. 23-31
Alba, M., Salvatori, R., A mouse with targeted ablation of the growth hormone-releasing hormone gene: A new model of isolated growth hormone deficiency (2004) Endocrinology, 145, pp. 4134-4143
Napolitano, L.A., Schmidt, D., Gotway, M.B., Ameli, N., Filbert, E.L., Ng, M.M., Growth hormone enhances thymic function in HIV-1-infected adults (2008) J Clin Invest, 118, pp. 1085-1098
Morrhaye, G., Kermani, H., Legros, J.J., Baron, F., Beguin, Y., Moutschen, M., Impact of growth hormone (GH) deficiency and GH replacement upon thymus function in adult patients (2009) PLoS One, 4, p. e5668
Gruver, A.L., Hudson, L.L., Sempowski, G.D., Immunosenescence of ageing (2007) J Pathol, 211, pp. 144-156
Palmer, D.B., The effect of age on thymic function (2013) Front Immunol, 4, p. 316
Naylor, K., Li, G., Vallejo, A.N., Lee, W.W., Koetz, K., Bryl, E., The influence of age on T cell generation and TCR diversity (2005) J Immunol, 174, pp. 7446-7452
Min, H., Montecino-Rodriguez, E., Dorshkind, K., Effects of aging on early B- and T-cell development (2005) Immunol Rev, 205, pp. 7-17
Lamberts, S.W., Van Den Beld, A.W., Van Der Lely, A.J., The endocrinology of aging (1997) Science, 278, pp. 419-424
Min, H., Montecino-Rodriguez, E., Dorshkind, K., Reassessing the role of growth hormone and sex steroids in thymic involution (2006) Clin Immunol, 118, pp. 117-123
Goya, R.G., Gagnerault, M.C., De Moraes, M.C., Savino, W., Dardenne, M., In vivo effects of growth hormone on thymus function in aging mice (1992) Brain Behav Immun, 6, pp. 341-354
Montecino-Rodriguez, E., Clark, R., Dorshkind, K., Effects of insulin-like growth factor administration and bone marrow transplantation on thymopoiesis in aged mice (1998) Endocrinology, 139, pp. 4120-4126
Bartke, A., Sun, L.Y., Longo, V., Somatotropic signaling: Trade-offs between growth, reproductive development, and longevity (2013) Physiol Rev, 93, pp. 571-598
Flurkey, K., Papaconstantinou, J., Miller, R.A., De, H., Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production (2001) Proc Natl Acad Sci U S A, 98, pp. 6736-6741
Liu, H., Bravata, D.M., Olkin, I., Nayak, S., Roberts, B., Garber, A.M., Systematic review: The safety and efficacy of growth hormone in the healthy elderly (2007) Ann Intern Med, 146, pp. 104-115
Williams, G.C., Pleiotropy, natural selection, and the evolution of senescence (1957) Evolution, 11, pp. 398-411
Dorshkind, K., Horseman, N.D., The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: Insights from genetic models of hormone and hormone receptor deficiency (2000) Endocr Rev, 21, pp. 292-312