Reference : Integrated continuous flow photoreactors: Photooxidation of (L)-methionine with singl...
Scientific congresses and symposiums : Poster
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/204563
Integrated continuous flow photoreactors: Photooxidation of (L)-methionine with singlet oxygen
English
[fr] Photoréacteur en continu intégré : Photooxydation de la (L)-méthionine avec de l'oxygène singulet
Emmanuel, Noémie mailto [Université de Liège > Département de chimie (sciences) > Center for integrated Technology and Organic Synthesis > Ph.D. Student (1st year) >]
Mendoza Gallego, Carlos mailto [Université de Liège > Department of Chemical Engineering > Génie chimique - Nanomatériaux et interfaces >]
Lismont, Marjorie mailto [Université de Liège > Département de physique > Biophotonique >]
Dreesen, Laurent mailto [Université de Liège > Département de physique > Biophotonique >]
Heinrichs, Benoît mailto [Université de Liège > Department of Chemical Engineering > Génie chimique - Nanomatériaux et interfaces >]
Monbaliu, Jean-Christophe mailto [Université de Liège > Département de chimie (sciences) > Centre for Integrated Technology and Organic Synthesis > >]
8-Dec-2016
A5
No
No
National
20th Sigma-Aldrich Symposium
du 08 décembre 2016 au 09 décembre 2016
Sigma-Aldrich
Blankenberge
Belgique
[en] (L)-methionine ; microfluidics ; continuous-flow ; photooxidation ; singlet oxygen
[en] Development of photochemistry in macroscopic batch reaction vessels is hampered due to inherent limitations: light penetration remains superficial, resulting in inhomogeneous irradiation and hence to side-reactions or product degradation due to overexposure. The recent implementation of photochemical processes in microreactors under continuous-flow conditions appeared to be much more powerful than its batch analogue in terms of irradiation efficiency and light penetration. Furthermore, the fine control of residence time ensures an accurate control of the irradiation time, avoiding side-reactions and degradation. The photooxidation of (L)-methionine with singlet oxygen using Rose Bengal as a sensitizer was successfully implemented in a microreactor setup and led to total and selective conversion into methionine sulfoxide, an important building block for the organic synthesis of peptides or functionalized amino acid. The reaction was performed in 2 min while the same reaction in batch took 2h.
Center for Integrated Technology and Organic Synthesis
http://hdl.handle.net/2268/204563

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