Reference : Unexpected high levels of Cobalamin (Vitamin B12): Numerous interferences are decreas...
Scientific congresses and symposiums : Poster
Human health sciences : Laboratory medicine & medical technology
http://hdl.handle.net/2268/204553
Unexpected high levels of Cobalamin (Vitamin B12): Numerous interferences are decreased by PEG treatment.
English
LADANG, Aurélie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs Biologie clinique - Pool assistants >]
VRANKEN, Laura mailto [Centre Hospitalier Universitaire de Liège - CHU > > Secteur commun NDB >]
CAVALIER, Etienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de chimie clinique >]
Oct-2016
No
No
National
Congrès de la société belge de médecine de laboratoire
du 14 au 15 octobre 2016
RBSLM
Liège
[en] cobalamin ; PEG
[en] Cobalamin (Vitamin B12) deficiency is a common cause of anemia. High levels of serum cobalamin is mainly due to cobalamin supplementation. It has also been associated with hematological malignancies, liver or renal diseases. Cobalamin is sometimes found elevated in autoimmune disorders and infectious diseases but concerns are raised on the fact that those serum increases might be due to interference with immunoassays.
Those data’s shed the lights on the high prevalence of interference in patients with unexpected high cobalamin level. Precipitation with PEG appears to be an easy and costless method to increase the reliability of cobalamin dosage. In accordance with our results, we recommand to treat systematically every serum with a cobalamin >1500 ng/L.
Professionals
http://hdl.handle.net/2268/204553

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