Review of soluble biomarkers of osteoarthritis: lessons from animal model

[en] Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no way to detect the disease at a molecular level, before the appearance of structural changes and symptoms. So an attractive alternative for monitoring OA is the measurement of biochemical markers in blood, urine, or synovial fluid, which could reflect metabolic changes in joint tissue and therefore disease onset and progression. Animal models are relevant to investigate the early stage of OA and metabolic changes occurring in joint tissues. The goal of this narrative review is to summarize the scientific data available in the literature on soluble biomarkers in animal models of OA.

Disciplines :

Rheumatology

Author, co-author :

Legrand, Catherine ; Université de Liège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)

Lambert, Cécile ; Université de Liège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)

Comblain, Fanny ; Université de Liège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)

Sanchez, Christelle ; Université de Liège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)

Henrotin, Yves ; Université de Liège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)

Language :

English

Title :

Review of soluble biomarkers of osteoarthritis: lessons from animal model

Publication date :

2017

Journal title :

Cartilage

ISSN :

1947-6035

eISSN :

1947-6043

Publisher :

Cartilage OnlineFirst

Pages :

1-23

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 19 December 2016

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