ATP Augments von Willebrand Factor-dependent Shear-induced Platelet Aggregation through Ca2+-Calmodulin and Myosin Light Chain Kinase Activation - 2004
[en] Shear stress triggers von Willebrand factor (VWF) binding to platelet glycoprotein Ibalpha and subsequent integrin alpha(IIb)beta(3)-dependent platelet aggregation. Concomitantly, nucleotides are released from plateletdense granules, and ADP is known to contribute to shear-induced platelet aggregation (SIPA). This study shows that ATP also contributes to SIPA. The ATP-gated P2X(1) ion channel induces MLC-mediated cytoskeletal rearrangements that increases platelet degranulation during VWF-triggered platelet activation.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Oury, Cécile ; Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB
Sticker, Elsie; Katholieke Universiteit Leuven - KUL > Departement of Molecular and Cellular Medicine > CMVB
Cornelissen, Heidi; Katholieke Universiteit Leuven - KUL > Department of Molecular and Cellular Medicine > CMVB
De Vos, Rita; Katholieke Universiteit Leuven - KUL > Department of Medical Diagnostic Sciences > Morphology and Molecular Pathology Section
Vermylen, Jos; Katholieke Universiteit Leuven - KUL > Department of Molecular and Cellular Medicine > CMVB
Hoylaerts, Marc F; Katholieke Universiteit Leuven - KUL > Department of Molecular and Cellular Medicine > CMVB
Language :
English
Title :
ATP Augments von Willebrand Factor-dependent Shear-induced Platelet Aggregation through Ca2+-Calmodulin and Myosin Light Chain Kinase Activation
Publication date :
2004
Journal title :
Journal of Biological Chemistry
ISSN :
0021-9258
eISSN :
1083-351X
Publisher :
American Society for Biochemistry and Molecular Biology, Baltimore, United States - Maryland
Kroll, M. H., Hellums, J. D., McIntire, L. V., Schafer, A. I., and Moake, J. L. (1996) Blood 88, 1525-1541
Berndt, M. C., Shen, Y., Dopheide, S. M., Gardiner, E. E., and Andrews, R. K. (2001) Thromb. Haemostasis 86, 178-188
Ikeda, Y., Murata, M., and Goto, S. (1997) Ann. N. Y. Acad. Sci. 811, 325-336
Goto, S., Sakai, H., Goto, M., Ono, M., Ikeda, Y., Handa, S., and Ruggeri, Z. M. (1999) Circulation 99, 608-613
Konstantopoulos, K., Grotta, J. C., Sills, C., Wu, K. K., and Hellums, J. D. (1995) Thromb. Haemostasis 74, 1329-1334
Ruggeri, Z. M. (2003) Curr. Opin. Hematol. 10, 142-149
Yap, C. L., Anderson, K. E., Hughan, S. C., Dopheide, S. M., Salem, H. H., and Jackson, S. P. (2002) Blood 99, 151-158
Kroll, M. H., Hellums, J. D., Guo, Z., Durante, W., Razdan, K., Hrbolich, J. K., and Schafer, A. I. (1993) J. Biol. Chem. 268, 3520-3524
Kasirer-Friede, A., Cozzi, M. R., Mazzucato, M., De Marco, L., Ruggeri, Z. M., and Shattil, S. J. (2004) Blood 103, 3403-3411
Christodoulides, N., Feng, S., Resendiz, J. C., Berndt, M. C., and Kroll, M. H. (2001) Thromb. Res. 102, 133-142
Feng, S., Reséndiz, J. C., Lu, X., and Kroll, M. H. (2003) Blood 102, 2122-2129
Moritz, M. W., Reimers, R. C., Baker, R. K., Sutera, S. P., and Joist, J. H. (1983) J. Lab. Clin. Med. 101, 537-544
Moake, J. L., Turner, N. A., Stathopoulos, N. A., Nolasco, L., and Hellums, J. D. (1988) Blood 71, 1366-1374
Chow, T. W., Hellums, J. D., Moake, J. L., and Kroll, M. H. (1992) Blood 80, 113-120
Ikeda, Y., Handa, M., Kamata, T., Kawano, K., Kawai, Y., Watanabe, K. Kawakami, K., Sakai, K., Fukuyama, M., Itagaki, I., Yoshioka, A., and Ruggeri, Z. M. (1993) Thromb. Haemostasis 69, 496-502
Kunapuli, S. P., Dorsam, R. T., Kim, S., Quinton, T. M. (2003) Curr. Opin. Pharmacol. 3, 175-180
Goto, S., Tamura, N., Eto, K., Ikeda, Y., and Handa, S. (2002) Circulation 105, 2531-2536
Turner, N. A., Moake, J. L., and McIntire, L. V. (2001) Blood 98, 3340-3345
Reséndiz, J. C., Feng, S., Ji, G. A., Francis, K. A., Berndt, M. C., and Kroll, M. H. (2003) Mol. Pharmacol. 63, 639-645
Bodin, P., Bailey, D., and Burnstock, G. (1991) Br. J. Pharmacol. 103, 1203-1205
Nakai, K., Hayashi, T., Nagaya, S., Toyoda, H., Yamamoto, M., Shiku, H., Ikeda, Y., and Nishikawa, M. (1997) Life Sci. 60, 181-191
Bodin, P., and Burnstock, G. (2001) J. Cardiovasc. Pharmacol. 38, 900-908
Rolf, M. G., Brearley, C. A., and Mahaut-Smith, M. P. (2001) Thromb. Haemostasis 85, 303-308
Oury, C., Toth-Zsamboki, E., Thys, C., Tytgat, J., Vermylen, J., and Hoylaerts, M. F. (2001) Thromb. Haemostasis 86, 1264-1271
Toth-Zsamboki, E., Oury, C., De Vos, R., Vermylen, J., and Hoylaerts, M. F. (2003) J. Biol. Chem. 278, 46661-46667
Hechler, B., Lenain, N., Marchese, P., Vial, C., Heim, V., Freund, M., Cazenave, J. P., Cattaneo, M., Ruggeri, Z. M., Evans, R., and Gachet, C. (2003) J. Exp. Med. 198, 661-667
Oury, C., Kuijpers, M. J. E., Toth-Zsamboki, E., Bonnefoy, A., Danloy, S., Vreys, I., Feijge, M. A., De Vos, R., Vermylen, J., Heemskerk, J. W. M., and Hoylaerts, M. F. (2003) Blood 101, 3969-3976
Kageyama, S., Yamamoto, H., Nagano, M., Arisaka, H., Kayahara, T., and Yoshimoto, R. (1997) Br. J. Pharmacol. 122, 165-171
Oury, C., Toth-Zsamboki, E., Vermylen, J., and Hoylaerts, M. F. (2002) Blood 100, 2499-2505
Ikeda, Y., Handa, M., Kawano, K., Kamata, T., Murata, M., Araki, Y., Anbo, H., Kawai, Y., Watanabe, K., Itagaki, I., Sakai, K., and Ruggeri, Z. M. (1991) J. Clin. Investig. 87, 1234-1240
Flaumenhaft, R. (2003) Arterioscler. Thromb. Vasc. Biol. 23, 1152-1160
Oda, A., Yokoyama, K., Murata, M., Tokuhira, M., Nakamura, K., Handa, M., Watanabe, K., and Ikeda, Y. (1995) Thromb. Haemostasis 74, 736-742
Murugappan, S., Tuluc, F., Dorsam, R. T., Shankar, H., and Kunapuli, S. P. (2004) J. Biol. Chem. 279, 2360-2367
Bauer, M., Retzer, M., Wilde, J. I., Maschberger, P., Essler, M., Aepfelbacher, M., Watson, S. P., and Siess, W. (1999) Blood 94, 1665-1672
Paul, B. Z., Daniel, J. L., and Kunapuli, S. P. (1999) J. Biol. Chem. 274, 28293-28300
Zhang, Q., Zhao, B., Li, W., Oiso, N., Novak, E. K., Rusiniak, M. E., Gautam, R., Chintala, S., O'Brien, E. P., Zhang, Y., Roe, B. A., Elliott, R. W., Eicher, E. M., Liang, P., Kratz, C., Legius, E., Spritz, R. A., O'Sullivan, T. N., Copeland, N. G., Jenkins, N. A., and Swank, R. T. (2003) Nat. Genet. 33, 145-153
Schoenwaelder, S. M., Hughan, S. C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P. E., Salem, H. H., and Jackson, S. P. (2002) J. Biol. Chem. 277, 14738-14746
Painter, R. G., and Ginsberg, M. H. (1984) Exp. Cell Res. 155, 198-212
Quetglas, S., Leveque, C., Miquelis, R., Sato, K., and Seagar, M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 9695-9700
Vogt, S., Grosse, R., Schultz, G., and Offermans, S. (2003) J. Biol. Chem. 278, 28743-28749
Liu, F., Verin, A. D., Wang, P., Day, R., Wersto, R. P., Chrest, F. J., English, D. K., and Garcia, J. G. (2001) Am. J. Respir. Cell Mol. Biol. 24, 711-719
Burridge, K., Chrzanowska-Wodnicka, M., and Zhong, C. (1997) Trends Cell Biol. 7, 342-347
Pasquet, J. M., Noury, M., and Nurden, A. T. (2002) Thromb. Haemostasis 88, 115-122
Paul, B. Z., Jin, J., and Kunapuli, S. P. (1999) J. Biol. Chem. 274, 29108-29114
